L
Ludmil B. Alexandrov
Researcher at University of California, San Diego
Publications - 164
Citations - 36334
Ludmil B. Alexandrov is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Biology & Cancer. The author has an hindex of 60, co-authored 117 publications receiving 28167 citations. Previous affiliations of Ludmil B. Alexandrov include Beth Israel Deaconess Medical Center & University of California, Berkeley.
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Journal ArticleDOI
Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus
Jens Luebeck,Alvin Wei Tian Ng,Patricia C. Galipeau,Xiaohong Li,Carissa A. Sanchez,Annalise Katz-Summercorn,Hoon Kim,Sriganesh Jammula,Yudou He,Scott M. Lippman,Roel G.W. Verhaak,Carlo C. Maley,Ludmil B. Alexandrov,Brian J. Reid,Rebecca C. Fitzgerald,Thomas G. Paulson,Howard Y. Chang,Sihan Wu,Vineet Bafna,Paul S. Mischel +19 more
TL;DR: In this article , the authors analyzed whole-genome sequencing (WGS) data from patients with oesophageal adenocarcinoma (EAC) or Barrett's o esophagus and found that the frequency of ecDNA increased between Barrett's-oesophagus-associated early-stage and late-stage (43%) EAC.
Posted ContentDOI
Topography of mutational signatures in human cancer
Burcak Otlu,Marcos Díaz-Gay,Ian Vermes,Erik N. Bergstrom,Maria Zhivagui,Mark Barnes,Ludmil B. Alexandrov +6 more
TL;DR: Comprehensive topography analysis of mutational signatures encompassing 82,890,857 somatic mutations in 5,120 whole-genome sequenced tumours integrated with 516 tissue-matched topographical features from the ENCODE project allows researchers to explore the interactions between somatic mutational processes and genome architecture within and across cancer types.
Journal ArticleDOI
Multiomic analysis of malignant pleural mesothelioma identifies molecular axes and specialized tumor profiles driving intertumor heterogeneity
L. Mangiante,Nicolas Alcala,Alexandra Sexton-Oates,Alex Di Genova,Abel Gonzalez-Perez,Azhar Khandekar,Erik N. Bergstrom,Jaehee Kim,Xiran Liu,Ricardo Blazquez-Encinas,Colin Giacobi,N. Le Stang,Sandrine Boyault,Cyrille Cuenin,Séverine Tabone-Eglinger,Francesca Damiola,Catherine Voegele,Maude Ardin,Marie-Cécile Michallet,Lorraine Soudade,Tiffany M. Delhomme,Arnaud Poret,Marie Brevet,Marie-Christine Copin,Sophie Giusiano-Courcambeck,Diane Damotte,Cécile Girard,Véronique Hofman,Paul Hofman,Jérôme Mouroux,Charlotte Cohen,Stéphanie Lacomme,Julien Mazieres,Vincent Thomas de Montpréville,Corinne Perrin,Gaétane Planchard,Nathalie Rousseau,Isabelle Rouquette,Christine Sagan,Arnaud Scherpereel,Françoise Thivolet,Jean-Michel Vignaud,Didier Jean,A. Gilg Soit Ilg,Robert Olaso,Vincent Meyer,Anne Boland-Auge,Jean-François Deleuze,J. Altmuller,Peter John Nuernberg,Alejandro Ibáñez-Costa,Justo P. Castaño,Sylvie Lantuejoul,Akram Ghantous,Charles Maussion,Pierre Courtiol,Hector Hernandez-Vargas,Christophe Caux,Nicolas Girard,Nuria Lopez-Bigas,Ludmil B. Alexandrov,Françoise Galateau-Sallé,Matthieu Foll,Lynnette Fernandez-Cuesta +63 more
TL;DR: In this paper , a morphomolecular classification of mesothelioma based on ploidy, tumor cell morphology, adaptive immune response and CpG island methylator profile is presented.
Posted ContentDOI
SigProfilerMatrixGenerator: a tool for visualizing and exploring patterns of small mutational events
Erik N. Bergstrom,Mi Ni Huang,Uma Mahto,Mark Barnes,Michael R. Stratton,Steven G. Rozen,Ludmil B. Alexandrov +6 more
TL;DR: SigProfilerMatrixGenerator is a computational tool designed for optimized exploration and visualization of mutational patterns for all types of small mutational events and is the first to provide support for classifying doublet base substitutions and small insertions and deletions.
Journal ArticleDOI
Somatic 9p24.1 alterations in HPV– head and neck squamous cancer dictate immune microenvironment and anti-PD-1 checkpoint inhibitor activity
Xin Zhao,Ezra E.W. Cohen,William N. William,Joy J. Bianchi,Jim Abraham,Daniel Magee,David Spetzler,J. Silvio Gutkind,Ludmil B. Alexandrov,Webster K. Cavenee,Scott M. Lippman,Teresa Davoli +11 more
TL;DR: The 9p24.1 expression threshold of 60th percentile, ICT median survival was 3-fold higher than chemotherapy; below this threshold, chemotherapy survival rates exceeded ICT as mentioned in this paper .