L
Ludmil B. Alexandrov
Researcher at University of California, San Diego
Publications - 164
Citations - 36334
Ludmil B. Alexandrov is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Biology & Cancer. The author has an hindex of 60, co-authored 117 publications receiving 28167 citations. Previous affiliations of Ludmil B. Alexandrov include Beth Israel Deaconess Medical Center & University of California, Berkeley.
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Journal ArticleDOI
The origins and vulnerabilities of two transmissible cancers in Tasmanian devils
Maximilian R Stammnitz,Tim H. H. Coorens,Kevin Gori,Dane Hayes,Beiyuan Fu,Jinhong Wang,Daniel E. Martin-Herranz,Ludmil B. Alexandrov,Adrian Baez-Ortega,Syd Barthorpe,Alexandra Beck,Francesca Giordano,Graeme W. Knowles,Young Mi Kwon,George T. Hall,Stacey Price,Ruth J. Pye,Jose M. C. Tubio,Hannah V. Siddle,Sukhwinder Singh Sohal,Gregory M. Woods,Ultan McDermott,Fengtang Yang,Mathew J. Garnett,Zemin Ning,Elizabeth P. Murchison +25 more
TL;DR: It is implied that Tasmanian devils may have inherent susceptibility to transmissible cancers and present a suite of therapeutic compounds for use in conservation.
Journal ArticleDOI
Specificity and Heterogeneity of Terahertz Radiation Effect on Gene Expression in Mouse Mesenchymal Stem Cells
Boian S. Alexandrov,Boian S. Alexandrov,M. Lisa Phipps,Ludmil B. Alexandrov,L. G. Booshehri,Anna Erat,Anna Erat,Janice M. Zabolotny,Charles H. Mielke,Hou-Tong Chen,George Rodriguez,Kim Ø. Rasmussen,Jennifer S. Martinez,Alan R. Bishop,Anny Usheva +14 more
TL;DR: It is proposed that terahertz radiation has potential for non-contact control of cellular gene expression and for association between gene upregulation and propensity for DNA breathing.
Journal ArticleDOI
Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways.
Christopher D. Steele,Maxime Tarabichi,Dahmane Oukrif,Amy P. Webster,Hongtao Ye,Matthew Fittall,Patrick Lombard,Inigo Martincorena,Patrick S. Tarpey,Grace Collord,Kerstin Haase,Sandra J. Strauss,Sandra J. Strauss,Fitim Berisha,Heli Vaikkinen,Pawan Dhami,Marnix Jansen,Marnix Jansen,Sam Behjati,Sam Behjati,M Fernanda Amary,Roberto Tirabosco,Andrew Feber,Peter J. Campbell,Peter J. Campbell,Ludmil B. Alexandrov,Peter Van Loo,Peter Van Loo,Adrienne M. Flanagan,Adrienne M. Flanagan,Nischalan Pillay,Nischalan Pillay +31 more
TL;DR: This work sought to unravel the molecular basis of the structural complexity in USARCs by integrating DNA sequencing, ploidy analysis, gene expression, and methylation profiling, and identified whole genome duplication as a prevalent and pernicious force in US ARC tumorigenesis.
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Biological and prognostic impact of APOBEC-induced mutations in the spectrum of plasma cell dyscrasias and multiple myeloma cell lines.
Francesco Maura,Mia Petljak,Marta Lionetti,Ingrid Cifola,Winnie S. Liang,Eva Pinatel,Ludmil B. Alexandrov,Anthony Fullam,Inigo Martincorena,Kevin J. Dawson,Nicos Angelopoulos,Mehmet Kemal Samur,Raphael Szalat,Jorge Zamora,Patrick S. Tarpey,Helen Davies,Paolo Corradini,KC Anderson,Stephane Minvielle,Antonino Neri,Hervé Avet-Loiseau,Jonathan J Keats,Peter J. Campbell,Nikhil C. Munshi,Nikhil C. Munshi,Niccolo Bolli,Niccolo Bolli +26 more
TL;DR: Biological and prognostic impact of APOBEC-induced mutations in the spectrum of plasma cell dyscrasias and multiple myeloma cell lines is studied.
Journal ArticleDOI
A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers
Dominik Glodzik,Sandro Morganella,Helen Davies,Peter T. Simpson,Yang Li,Xueqing Zou,Javier Diez-Perez,Johan Staaf,Ludmil B. Alexandrov,Ludmil B. Alexandrov,Marcel Smid,Arie B. Brinkman,Inga H. Rye,Inga H. Rye,Hege G. Russnes,Hege G. Russnes,Keiran Raine,Colin A. Purdie,Sunil R. Lakhani,Sunil R. Lakhani,Alastair M. Thompson,Ewan Birney,Hendrik G. Stunnenberg,Marc J. van de Vijver,John W.M. Martens,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Andrea L. Richardson,Gu Kong,Alain Viari,Douglas F. Easton,Gerard I. Evan,Peter J. Campbell,Michael R. Stratton,Serena Nik-Zainal,Serena Nik-Zainal +35 more
TL;DR: A somatic-rearrangement mutational process affecting coding sequences and noncoding regulatory elements and contributing a continuum of driver consequences, from modest to strong effects, thereby supporting a polygenic model of cancer development.