L
Ludmil B. Alexandrov
Researcher at University of California, San Diego
Publications - 164
Citations - 36334
Ludmil B. Alexandrov is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Biology & Cancer. The author has an hindex of 60, co-authored 117 publications receiving 28167 citations. Previous affiliations of Ludmil B. Alexandrov include Beth Israel Deaconess Medical Center & University of California, Berkeley.
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Journal ArticleDOI
The mutational signature profile of known and suspected human carcinogens in mice.
Laura Riva,Arun R. Pandiri,Yun Li,Alastair Droop,James Hewinson,Michael A. Quail,Vivek Iyer,Rebecca Shepherd,Ronald A. Herbert,Peter J. Campbell,Robert C. Sills,Ludmil B. Alexandrov,Allan Balmain,David J. Adams +13 more
TL;DR: A genomic analysis of tumors in mice caused by known or suspected carcinogens shows that most carcinogens do not generate distinct mutational signatures, with most mutations, including driver mutations, resulting from tissue-specific endogenous processes.
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Non-thermal effects of terahertz radiation on gene expression in mouse stem cells
Boian S. Alexandrov,Kim Ø. Rasmussen,Alan R. Bishop,Anny Usheva,Ludmil B. Alexandrov,Shou Chong,Yossi Dagon,L. G. Booshehri,Charles H. Mielke,M. Lisa Phipps,Jennifer S. Martinez,Hou-Tong Chen,George Rodriguez +12 more
TL;DR: It is found that temperature increases were minimal, and that the differential expression of the investigated heat shock proteins was unaffected, while the expression of certain other genes showed clear effects of the THz irradiation after prolonged, broad-band exposure.
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A nonlinear dynamic model of DNA with a sequence-dependent stacking term
Boian S. Alexandrov,Vladimir Gelev,Yevgeniya Monisova,Ludmil B. Alexandrov,Alan R. Bishop,Kim Ø. Rasmussen,Anny Usheva +6 more
TL;DR: The extended PBD model of DNA is extended to include a sequence-dependent stacking term, resulting in a model that can accurately describe the melting behavior of homogenous and periodic sequences and facilitate thermodynamic and dynamic simulations of important genomic regions such as CpG islands and disease-related repeats.
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Signatures of copy number alterations in human cancer
Christopher D. Steele,Ammal Abbasi,S M Ashiqul Islam,Amy L. Bowes,Azhar Khandekar,Kerstin Haase,Shadi Hames-Fathi,Dolapo Ajayi,Annelien Verfaillie,Pawandeep Dhami,Alex P. McLatchie,Matthias Lechner,Nicholas Light,Adam Shlien,David Malkin,Andrew Feber,Paula Proszek,Tom Lesluyes,Fredrik Mertens,Adrienne M. Flanagan,Maxime Tarabichi,Peter Van Loo,Ludmil B. Alexandrov,Nischalan Pillay +23 more
TL;DR: In this article , the authors present a conceptual framework to examine the patterns of copy number alterations in human cancer and reveal a diversity of mutational processes that give rise to these alterations.
Journal ArticleDOI
Strength of immune selection in tumors varies with sex and age
Andrea Castro,Rachel Marty Pyke,Xinlian Zhang,Wesley K. Thompson,Chi-Ping Day,Ludmil B. Alexandrov,Maurizio Zanetti,Hannah Carter +7 more
TL;DR: It is found that tumors in younger and female individuals accumulate more poorly presented driver mutations than those in older and male patients, despite no differences in MHC genotype.