L
Ludmil B. Alexandrov
Researcher at University of California, San Diego
Publications - 164
Citations - 36334
Ludmil B. Alexandrov is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Biology & Cancer. The author has an hindex of 60, co-authored 117 publications receiving 28167 citations. Previous affiliations of Ludmil B. Alexandrov include Beth Israel Deaconess Medical Center & University of California, Berkeley.
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Journal ArticleDOI
Transmissible Dog Cancer Genome Reveals the Origin and History of an Ancient Cell Lineage
Elizabeth P. Murchison,Elizabeth P. Murchison,David C. Wedge,Ludmil B. Alexandrov,Beiyuan Fu,Inigo Martincorena,Zemin Ning,Jose M. C. Tubio,Emma I. Werner,Jan Allen,Andrigo Barboza De Nardi,Edward M Donelan,Gabriele Marino,Ariberto Fassati,Peter J. Campbell,Fengtang Yang,Austin Burt,Robin A. Weiss,Michael R. Stratton +18 more
TL;DR: Although CTVT has acquired a massive number of genomic alterations, including hundreds of times more somatic mutations than are normally found in human cancers, the tumor cell genome has remained diploid and stable.
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A Specific Mutational Signature Associated with DNA 8-Oxoguanine Persistence in MUTYH-defective Colorectal Cancer
Alessandra Viel,Alessandro Bruselles,Ettore Meccia,Mara Fornasarig,Michele Quaia,Vincenzo Canzonieri,Eleonora Policicchio,Emanuele Damiano Luca Urso,Marco Agostini,Maurizio Genuardi,Emanuela Lucci-Cordisco,Tiziana Venesio,Aline Martayan,Maria Grazia Diodoro,Lupe Sanchez-Mete,Vittoria Stigliano,Filomena Mazzei,Francesca Grasso,Alessandro Giuliani,Marta Baiocchi,Roberta Maestro,Giuseppe Giannini,Marco Tartaglia,Ludmil B. Alexandrov,Ludmil B. Alexandrov,Margherita Bignami +25 more
TL;DR: In this article, the authors performed whole-exome sequencing to reveal a modest mutator phenotype in colorectal cancer associated with MUTYH-associated polyposis (MAP) syndrome.
Journal ArticleDOI
A mutational signature in gastric cancer suggests therapeutic strategies
Ludmil B. Alexandrov,Serena Nik-Zainal,Serena Nik-Zainal,Hoi Cheong Siu,Suet Yi Leung,Michael R. Stratton +5 more
TL;DR: It is demonstrated that, in addition to breast, ovarian and pancreatic cancers, gastric cancer is another cancer type that exhibits this mutational signature and may benefit from either platinum therapy or PARP inhibitors.
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SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair
Nnennaya Kanu,Eva Grönroos,Pierre Martinez,Rebecca A. Burrell,X. Yi Goh,Jirina Bartkova,Apolinar Maya-Mendoza,Martin Mistrik,Andrew Rowan,Harshil Patel,Adam Rabinowitz,P East,Gareth A. Wilson,Claudio R. Santos,Nicholas McGranahan,Sakshi Gulati,Marco Gerlinger,Nicolai Juul Birkbak,Nicolai Juul Birkbak,Tejal Joshi,Ludmil B. Alexandrov,Michael R. Stratton,Thomas Powles,Nik Matthews,Paul A. Bates,Aengus Stewart,Zoltan Szallasi,Zoltan Szallasi,James Larkin,Jiri Bartek,Charles Swanton +30 more
TL;DR: A role for SETD2 in maintaining genome integrity through nucleosome stabilization, suppression of replication stress and the coordination of DNA repair is suggested.
Journal ArticleDOI
Genomic patterns of progression in smoldering multiple myeloma
Niccolo Bolli,Niccolo Bolli,Francesco Maura,Francesco Maura,Stephane Minvielle,Dominik Gloznik,Raphael Szalat,Anthony Fullam,Inigo Martincorena,Kevin J. Dawson,Mehmet Kemal Samur,Jorge Zamora,Patrick S. Tarpey,Helen Davies,Mariateresa Fulciniti,Masood A. Shammas,Yu-Tzu Tai,Florence Magrangeas,Philippe Moreau,Paolo Corradini,Kenneth C. Anderson,Ludmil B. Alexandrov,David C. Wedge,Hervé Avet-Loiseau,Peter J. Campbell,Nikhil C. Munshi,Nikhil C. Munshi +26 more
TL;DR: The genomic landscape at the SMM stage is very similar to MM, but trajectories of evolution can vary from patient to patient, and activation-induced cytidine deaminase plays a major role in shaping the mutational landscape of early subclinical phases.