L
Ludmil B. Alexandrov
Researcher at University of California, San Diego
Publications - 164
Citations - 36334
Ludmil B. Alexandrov is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Biology & Cancer. The author has an hindex of 60, co-authored 117 publications receiving 28167 citations. Previous affiliations of Ludmil B. Alexandrov include Beth Israel Deaconess Medical Center & University of California, Berkeley.
Papers
More filters
Posted ContentDOI
The genomic and epigenomic evolutionary history of papillary renal cell carcinomas
Bin Zhu,Maria Luana Poeta,Manuela Costantini,Tongwu Zhang,Jianxin Shi,Steno Sentinelli,Wei Zhao,Vincenzo Pompeo,Maurizio Cardelli,Boian S. Alexandrov,Burcak Otlu,Xing Hua,Kristine Jones,Seth A. Brodie,Jorge R. Toro,Meredith Yeager,Mingyi Wang,Belynda Hicks,Ludmil B. Alexandrov,Kevin M. Brown,David C. Wedge,Stephen J. Chanock,Vito Michele Fazio,Vito Michele Fazio,Michele Gallucci,Maria Teresa Landi +25 more
TL;DR: It is suggested that a single biopsy would be sufficient to identify the important genetic drivers of papillary renal cell carcinoma (pRCC) and targeting large-scale SCNAs may improve pRCC treatment, which is currently poor.
Posted ContentDOI
Mitotic tethering enables en masse inheritance of a shattered micronuclear chromosome
TL;DR: Inducible degrons are used to demonstrate that chromothriptically produced pieces of a micronucleated chromosome are tethered together in mitosis by a protein complex consisting of Mediator of DNA damage checkpoint 1, DNA Topoisomerase II Binding Protein 1, and Cellular Inhibitor of PP2A (CIP2A), thereby enabling en masse segregation to the same daughter cell.
Journal ArticleDOI
EP007/#994 Bay 1895344, a novel ATR inhibitor, demonstrates in vivo activity against ATRX altered uterine leiomyosarcoma
Justin Harold,Diego D Manavella,Stefania Bellone,Eric R. Siegel,T. Hartwich,Luca Zammataro,Levent Mutlu,Gary Altwerger,Gulden Menderes,Elena Ratner,Gloria S. Huang,Mitchell Clark,Vaagn Andikyan,Masoud Azodi,Peter Schwarz,Ludmil B. Alexandrov,Alessandro D. Santin +16 more
TL;DR: In this paper , the authors investigated the in vivo activity of a novel ATR inhibitor, BAY 1895344, against ATRX altered uLMS, which showed promising in- vivo activity against a PDX model of ULMS with no significant toxicity.
Journal ArticleDOI
Thank you to eBioMedicine's clinical and statistical peer reviewers in 2022
Dag Aarsland,Zaid A Abassi,Geoffrey W. Abbott,Salim Abdol Karim,Vida Abedi,Hassan Abolhassani,El-Ghar Abou,Moulinath Acharya,Balazs Acs,Taylor Adams,Demilade Adedinsewo,Adebowale Adeyemo,Ahmed Afzal,Dritan Agalliu,Shipra Agarwal,Alessio Aghemo,Selidji T Agnandji,Gul Ahmad,Rasheed Ahmad,Bilal Ahmed,Vineet Ahuja,Clemens Aigner,Hiroyuki Akai,Muhammad Waheed Akhtar,David P. Al-Adra,Nehad M. Alajez,Matthew T. Albaugh,C. Alexander,Ludmil B. Alexandrov,Hussein Kadhem Al-Hakeim,Fowzan S. Alkuraya,Hanny Al-Samkari,Daniel Altmann,Friedrich Altmann,Alejandra Álvarez,Carlos Henrique Alves,Mohammad Aman,Christopher Ambrose,Amedeo Amedei,Jing An,Beau M. Ances,Petronela Ancuta,Bogi Andersen,Ferdinando F. Andrade,Ioanna Andreadou,Trevor E. Angell,Luis Apolonia,Víctor,Jean Armengaud,Gary Armstrong,Alejandro C. Arroliga,Lourdes Arruvito,Per Arvidsson,Eishi Asano,Nicole E. Ashpole,Vasilios G. Athyros,Mukundan Attur,Tanya Augustine,Thiago Vinicius Ávila,A. Ayala,Monawar Aziz,Livio Azzoni,Sabyasachi Baboo,S. Babu,Martin Bachmann,Eduardo Back Sternick,P. Bryon Backenson,A R Badley,Jared M. Baeten,Nathan Bahr,Shasha Bai,Xueli Bai,Dalan Bailey,James Baker,Christine E. Bear,Richard Beatson,I. Beau,Benjamin Becker,Michael Becker,M. Beer,J L Beeson,Paul Beggs,Maik Behrens,A. Bei,Jin Bei,Juliane +85 more
Posted ContentDOI
Comprehensive repertoire of the chromosomal alteration and mutational signatures across 16 cancer types from 10,983 cancer patients.
Andrew Everall,Avraam Tapinos,Aliah Hazmah Hawari,Alex J. Cornish,Amit Sud,Daniel Chubb,Ben Kinnersley,Anna Frangou,Miguel Barquín,Josephine Jung,David N. Church,G. England,Ludmil B. Alexandrov,Richard S. Houlston,Andreas Gruber,David C. Wedge +15 more
TL;DR: In this article , the Catalogue of Somatic Mutations in Cancer (COSMIC) was used to extract structural variations (SV) signatures from whole-genome sequencing (WGS) data.