L
Ludmil B. Alexandrov
Researcher at University of California, San Diego
Publications - 164
Citations - 36334
Ludmil B. Alexandrov is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Biology & Cancer. The author has an hindex of 60, co-authored 117 publications receiving 28167 citations. Previous affiliations of Ludmil B. Alexandrov include Beth Israel Deaconess Medical Center & University of California, Berkeley.
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Journal ArticleDOI
Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue
Colin Cooper,Colin Cooper,Rosalind A. Eeles,Rosalind A. Eeles,David C. Wedge,Peter Van Loo,Peter Van Loo,Peter Van Loo,Gunes Gundem,Ludmil B. Alexandrov,Barbara Kremeyer,Adam Butler,Andy G. Lynch,Niedzica Camacho,Charles E. Massie,Jonathan Kay,Hayley J. Luxton,S. Edwards,Zsofia Kote-Jarai,Nening Dennis,Sue Merson,Daniel Leongamornlert,Jorge Zamora,Cathy Corbishley,Sarah Thomas,Serena Nik-Zainal,Manasa Ramakrishna,Sarah O’Meara,Lucy Matthews,Jeremy Clark,Rachel Hurst,Richard Mithen,Robert G. Bristow,Robert G. Bristow,Paul C. Boutros,Paul C. Boutros,Michael Fraser,Michael Fraser,Susanna L. Cooke,Keiran Raine,David T. Jones,Andrew Menzies,Lucy Stebbings,Jon Hinton,Jon W. Teague,Stuart McLaren,Laura Mudie,Claire Hardy,Elizabeth Anderson,Olivia Joseph,Victoria Goody,Ben Robinson,Mark Maddison,Stephen J. Gamble,Christopher Greenman,Daniel M. Berney,Steven Hazell,Naomi Livni,Cyril Fisher,Chris Ogden,Pardeep Kumar,Alan Thompson,C. R. J. Woodhouse,David Nicol,Erik Mayer,Tim Dudderidge,Nimish Shah,Vincent Gnanapragasam,Thierry Voet,Peter J. Campbell,Andrew Futreal,Douglas F. Easton,Anne Y. Warren,Christopher S. Foster,Michael R. Stratton,Hayley C. Whitaker,Ultan McDermott,Daniel Brewer,Daniel Brewer,Daniel Brewer,David E. Neal +80 more
TL;DR: Genome-wide DNA sequencing was used to decrypt the phylogeny of multiple samples from distinct areas of cancer and morphologically normal tissue taken from the prostates of three men, demonstrating the existence of ongoing abnormal mutational processes, consistent with field effects, underlying carcinogenesis.
Journal ArticleDOI
Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer
Young Seok Ju,Ludmil B. Alexandrov,Moritz Gerstung,Inigo Martincorena,Serena Nik-Zainal,Manasa Ramakrishna,Helen Davies,Elli Papaemmanuil,Gunes Gundem,Adam Shlien,Niccolo Bolli,Sam Behjati,Patrick S. Tarpey,Jyoti Nangalia,Charles E. Massie,Adam Butler,Jon W. Teague,George S. Vassiliou,Anthony R. Green,Du M-Q.,Ashwin Unnikrishnan,John E. Pimanda,Bin Tean Teh,Nikhil C. Munshi,Mel Greaves,Paresh Vyas,Adel K. El-Naggar,Tom Santarius,V P Collins,Richard Grundy,Jack A. Taylor,David N. Hayes,David Malkin,Christopher S. Foster,Anne Y. Warren,Hayley C. Whitaker,Daniel Brewer,Rosalind A. Eeles,Colin Cooper,David E. Neal,Tapio Visakorpi,W. Isaacs,G. S. Bova,Adrienne M. Flanagan,P A Futreal,Andy G. Lynch,Patrick F. Chinnery,Ultan McDermott,Michael R. Stratton,Peter J. Campbell +49 more
TL;DR: This study analyzed somatic alterations in mtDNA from 1675 tumors and identified 1907 somatic substitutions, which exhibited dramatic replicative strand bias, predominantly C > T and A > G on the mitochondrial heavy strand.
Journal ArticleDOI
Intra-tumour diversification in colorectal cancer at the single-cell level
Sophie F. Roerink,Nobuo Sasaki,Nobuo Sasaki,Henry Lee-Six,Matthew D. Young,Ludmil B. Alexandrov,Sam Behjati,Sam Behjati,Thomas J. Mitchell,Thomas J. Mitchell,Sebastian Grossmann,Howard Lightfoot,David A. Egan,Apollo Pronk,Niels Smakman,Joost van Gorp,Elizabeth Anderson,Stephen J. Gamble,Chris Alder,Marc van de Wetering,Peter J. Campbell,Michael R. Stratton,Hans Clevers +22 more
TL;DR: The results indicate that colorectal cancer cells experience substantial increases in somatic mutation rate compared to normal coloreCTal cells, and that genetic diversification of each cancer is accompanied by pervasive, stable and inherited differences in the biological states of individual cancer cells.
Journal ArticleDOI
Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes
Jose M. C. Tubio,Yang Li,Young Seok Ju,Inigo Martincorena,Susanna L. Cooke,Marta Tojo,Gunes Gundem,Christodoulos P. Pipinikas,Jorge Zamora,Keiran Raine,Andrew Menzies,Pablo Román-García,Anthony Fullam,Moritz Gerstung,Adam Shlien,Patrick S. Tarpey,Elli Papaemmanuil,Stian Knappskog,Stian Knappskog,Stian Knappskog,Peter Van Loo,Peter Van Loo,Manasa Ramakrishna,Helen Davies,John Marshall,David C. Wedge,Jon W. Teague,Adam Butler,Serena Nik-Zainal,Serena Nik-Zainal,Ludmil B. Alexandrov,Sam Behjati,Lucy R. Yates,Niccolo Bolli,Niccolo Bolli,Laura Mudie,Claire Hardy,Sancha Martin,Stuart McLaren,Sarah O’Meara,Elizabeth Anderson,Mark Maddison,Stephen J. Gamble,Christopher S. Foster,Anne Y. Warren,Hayley C. Whitaker,Daniel Brewer,Daniel Brewer,Rosalind A. Eeles,Colin Cooper,Colin Cooper,David E. Neal,Andy G. Lynch,Tapio Visakorpi,William B. Isaacs,Laura Van't Veer,Carlos Caldas,Christine Desmedt,Christos Sotiriou,Samuel Aparicio,John A. Foekens,Jorunn E. Eyfjord,Sunil R. Lakhani,Sunil R. Lakhani,Gilles Thomas,Ola Myklebost,Paul N. Span,Anne Lise Børresen-Dale,Andrea L. Richardson,Marc J. van de Vijver,Anne Vincent-Salomon,Gert Van den Eynden,Adrienne M. Flanagan,Adrienne M. Flanagan,P. Andrew Futreal,P. Andrew Futreal,Sam M. Janes,G. Steven Bova,Michael R. Stratton,Ultan McDermott,Peter J. Campbell,Peter J. Campbell +81 more
TL;DR: It is found that 3′ transduction activity in a patient’s tumor was always associated with hypomethylation of that element, and in some cases transduction events can scatter exons, genes, and regulatory elements widely across the genome.
Journal ArticleDOI
Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer
Matthew K.H. Hong,Geoff Macintyre,David C. Wedge,Peter Van Loo,Keval M. Patel,Sebastian Lunke,Ludmil B. Alexandrov,Clare Sloggett,Marek Cmero,Francesco Marass,Dana W.Y. Tsui,Stefano Mangiola,Andrew Lonie,Haroon Naeem,Nikhil Sapre,Pramit M. Phal,Natalie Kurganovs,Xiaowen Chin,Michael Kerger,Anne Y. Warren,David E. Neal,Vincent Gnanapragasam,Nitzan Rosenfeld,John Pedersen,Andrew Ryan,Izhak Haviv,Anthony J. Costello,Niall M. Corcoran,Christopher M. Hovens +28 more
TL;DR: The precise direction of metastatic spread is revealed across four lethal prostate cancer patients using whole-genome and ultra-deep targeted sequencing of longitudinally collected primary and metastatic tumours and analysis of mutations associated with metastasis reveals an enrichment of TP53 mutations.