L
Luigi Ferrucci
Researcher at National Institutes of Health
Publications - 42
Citations - 4983
Luigi Ferrucci is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 24, co-authored 42 publications receiving 3516 citations. Previous affiliations of Luigi Ferrucci include Memorial Hospital of South Bend.
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Journal ArticleDOI
An epigenetic biomarker of aging for lifespan and healthspan
Morgan E. Levine,Ake T. Lu,Austin Quach,Brian H. Chen,Themistocles L. Assimes,Stefania Bandinelli,Lifang Hou,Andrea A. Baccarelli,James D. Stewart,Yun Li,Eric A. Whitsel,James G. Wilson,Alex P. Reiner,Abraham Aviv,Kurt Lohman,Yongmei Liu,Luigi Ferrucci,Steve Horvath +17 more
TL;DR: A new epigenetic biomarker of aging, DNAm PhenoAge, is developed that strongly outperforms previous measures in regards to predictions for a variety of aging outcomes, including all-cause mortality, cancers, healthspan, physical functioning, and Alzheimer's disease.
Journal ArticleDOI
The origins of age-related proinflammatory state
Luigi Ferrucci,Annamaria Corsi,Annamaria Corsi,Fulvio Lauretani,Fulvio Lauretani,Stefania Bandinelli,Stefania Bandinelli,Benedetta Bartali,Benedetta Bartali,Dennis D. Taub,Dennis D. Taub,Jack M. Guralnik,Jack M. Guralnik,Dan L. Longo,Dan L. Longo +14 more
TL;DR: Part of the "proinflammatory state" in older persons is related to the high prevalence of cardiovascular risk factor and morbidity.
Journal ArticleDOI
Sarcopenic obesity and inflammation in the InCHIANTI study
Matthew A. Schrager,E. Jeffrey Metter,Eleanor M. Simonsick,Alessandro Ble,Stefania Bandinelli,Fulvio Lauretani,Luigi Ferrucci,Luigi Ferrucci +7 more
TL;DR: It is suggested that global obesity and, to a greater extent, central obesity directly affect inflammation, which in turn negatively affects muscle strength, contributing to the development and progression of sarcopenic obesity.
Posted ContentDOI
A Proteomic Atlas of Senescence-Associated Secretomes for Aging Biomarker Development
Nathan Basisty,Abhijit Kale,Ok-Hee Jeon,Chisaka Kuehnemann,Therese Payne,Chirag Rao,Anja Holtz,Samah Shah,Luigi Ferrucci,Judith Campisi,Judith Campisi,Birgit Schilling +11 more
TL;DR: The analyses identify several candidate biomarkers of cellular senescence that overlap with aging markers in human plasma, including GDF15, STC1 and SERPINs, which significantly correlated with age in plasma from a human cohort, the Baltimore Longitudinal Study of Aging.
Journal ArticleDOI
Serum 25-Hydroxyvitamin D and Depressive Symptoms in Older Women and Men
Yuri Milaneschi,Michelle Shardell,Anna Maria Corsi,Rosamaria Vazzana,Stefania Bandinelli,Jack M. Guralnik,Luigi Ferrucci +6 more
TL;DR: It is suggested that hypovitaminosis D is a risk factor for the development of depressive symptoms in older persons and the strength of the prospective association is higher in women than in men.