M
Morgan E. Levine
Researcher at Yale University
Publications - 115
Citations - 9002
Morgan E. Levine is an academic researcher from Yale University. The author has contributed to research in topics: Epigenetics & DNA methylation. The author has an hindex of 29, co-authored 97 publications receiving 5656 citations. Previous affiliations of Morgan E. Levine include University of Southern California & University of California.
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Journal ArticleDOI
An epigenetic biomarker of aging for lifespan and healthspan
Morgan E. Levine,Ake T. Lu,Austin Quach,Brian H. Chen,Themistocles L. Assimes,Stefania Bandinelli,Lifang Hou,Andrea A. Baccarelli,James D. Stewart,Yun Li,Eric A. Whitsel,James G. Wilson,Alex P. Reiner,Abraham Aviv,Kurt Lohman,Yongmei Liu,Luigi Ferrucci,Steve Horvath +17 more
TL;DR: A new epigenetic biomarker of aging, DNAm PhenoAge, is developed that strongly outperforms previous measures in regards to predictions for a variety of aging outcomes, including all-cause mortality, cancers, healthspan, physical functioning, and Alzheimer's disease.
Journal ArticleDOI
DNA methylation-based measures of biological age: meta-analysis predicting time to death
Brian H. Chen,Riccardo E. Marioni,Riccardo E. Marioni,Elena Colicino,Marjolein J. Peters,Cavin K. Ward-Caviness,Pei-Chien Tsai,Nicholas S. Roetker,Allan C. Just,Ellen W. Demerath,Weihua Guan,Jan Bressler,Myriam Fornage,Myriam Fornage,Stephanie A. Studenski,Amy R. Vandiver,Ann Zenobia Moore,Toshiko Tanaka,Douglas P. Kiel,Liming Liang,Pantel S. Vokonas,Joel Schwartz,Kathryn L. Lunetta,Kathryn L. Lunetta,Joanne M. Murabito,Joanne M. Murabito,Stefania Bandinelli,Dena G. Hernandez,David Melzer,Mike A. Nalls,Luke C. Pilling,Timothy Ryan Price,Andrew B. Singleton,Christian Gieger,Rolf Holle,Anja Kretschmer,Florian Kronenberg,Sonja Kunze,Jakob Linseisen,Christine Meisinger,Wolfgang Rathmann,Melanie Waldenberger,Peter M. Visscher,Peter M. Visscher,Sonia Shah,Naomi R. Wray,Allan F. McRae,Oscar H. Franco,Albert Hofman,Albert Hofman,André G. Uitterlinden,Devin Absher,Themistocles L. Assimes,Morgan E. Levine,Ake T. Lu,Philip S. Tsao,Philip S. Tsao,Lifang Hou,JoAnn E. Manson,Cara L. Carty,Andrea Z. LaCroix,Alexander P. Reiner,Alexander P. Reiner,Tim D. Spector,Andrew P. Feinberg,Daniel Levy,Andrea A. Baccarelli,Andrea A. Baccarelli,Joyce B. J. van Meurs,Jordana T. Bell,Annette Peters,Ian J. Deary,James S. Pankow,Luigi Ferrucci,Steve Horvath +74 more
TL;DR: Evidence that epigenetic age predicts all-cause mortality above and beyond chronological age and traditional risk factors is strengthened and estimates that incorporate information on blood cell counts lead to highly significant associations with all- Cause mortality are demonstrated.
Journal ArticleDOI
Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population
Morgan E. Levine,Jorge Suarez,Sebastian Brandhorst,Priya Balasubramanian,Chia-Wei Cheng,Federica Madia,Luigi Fontana,Luigi Fontana,Mario G. Mirisola,Mario G. Mirisola,Jaime Guevara-Aguirre,Junxiang Wan,Giuseppe Passarino,Brian K. Kennedy,Min Wei,Pinchas Cohen,Eileen M. Crimmins,Valter D. Longo +17 more
TL;DR: It is suggested that low protein intake during middle age followed by moderate to high protein consumption in old adults may optimize healthspan and longevity.
Journal ArticleDOI
Quantification of biological aging in young adults.
Daniel W. Belsky,Avshalom Caspi,Renate Houts,Harvey J. Cohen,David L. Corcoran,Andrea Danese,HonaLee Harrington,Salomon Israel,Morgan E. Levine,Jonathan D. Schaefer,Karen Sugden,Ben Williams,Anatoli I. Yashin,Richie Poulton,Terrie E. Moffitt +14 more
TL;DR: It is indicated that aging processes can be quantified in people still young enough for prevention of age-related disease, opening a new door for antiaging therapies.
Journal ArticleDOI
An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease
Steve Horvath,Michael Gurven,Morgan E. Levine,Benjamin C. Trumble,Hillard Kaplan,Hooman Allayee,Beate Ritz,Brian H. Chen,Ake T. Lu,Tammy M. Rickabaugh,Beth D. Jamieson,Dianjianyi Sun,Shengxu Li,Wei Chen,Lluis Quintana-Murci,Maud Fagny,Michael S. Kobor,Philip S. Tsao,Philip S. Tsao,Alexander P. Reiner,Kerstin L. Edlefsen,Devin Absher,Themistocles L. Assimes +22 more
TL;DR: Epigenetic aging rates are significantly associated with sex, race/ethnicity, and to a lesser extent with CHD risk factors, but not with incident CHD outcomes.