D
Dao-Fu Dai
Researcher at University of Iowa
Publications - 83
Citations - 5113
Dao-Fu Dai is an academic researcher from University of Iowa. The author has contributed to research in topics: Mitochondrion & Oxidative stress. The author has an hindex of 29, co-authored 70 publications receiving 4338 citations. Previous affiliations of Dao-Fu Dai include Roy J. and Lucille A. Carver College of Medicine & University of Washington.
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Journal ArticleDOI
Mitochondrial Oxidative Stress Mediates Angiotensin II–Induced Cardiac Hypertrophy and Gαq Overexpression–Induced Heart Failure
Dao-Fu Dai,Simon C. Johnson,Jason J. Villarin,Michael T. Chin,Madeline Nieves-Cintrón,Tony Chen,David J. Marcinek,Gerald W. Dorn,Y. James Kang,Tomas A. Prolla,Luis Fernando Santana,Peter S. Rabinovitch +11 more
TL;DR: The data indicate the critical role of mitochondrial ROS in cardiac hypertrophy and failure and support the potential use of mitochondrial-targeted antioxidants for prevention and treatment of hypertensive cardiomyopathy.
Journal ArticleDOI
Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging
Dao-Fu Dai,Luis Fernando Santana,Marc Vermulst,Daniela M. Tomazela,Mary J. Emond,Michael J. MacCoss,Katherine A. Gollahon,George M. Martin,Lawrence A. Loeb,Warren C. Ladiges,Peter S. Rabinovitch +10 more
TL;DR: It is shown that cardiac aging in the mouse closely recapitulates human aging and demonstrates the critical role of mitochondrial reactive oxygen species in cardiac aging and the impact of cardiac aging on survival.
Journal ArticleDOI
Mitochondrial oxidative stress in aging and healthspan.
TL;DR: Evidence supporting the role of mitochondrial oxidative stress, mitochondrial damage and dysfunction in aging and healthspan, including cardiac aging, age-dependent cardiovascular diseases, skeletal muscle aging, neurodegenerative diseases, insulin resistance and diabetes as well as age-related cancers is reviewed.
Journal ArticleDOI
Mitochondria and Cardiovascular Aging
TL;DR: The evidence supporting the role of mitochondrial oxidative stress, mitochondrial damage and biogenesis as well as the crosstalk between mitochondria and cellular signaling in cardiac and vascular aging is reviewed.
Journal ArticleDOI
Mitochondrial targeted antioxidant peptide ameliorates hypertensive cardiomyopathy
Dao-Fu Dai,Tony Chen,Hazel H. Szeto,Madeline Nieves-Cintrón,Vassily I. Kutyavin,Luis Fernando Santana,Peter S. Rabinovitch +6 more
TL;DR: Mitochondrial targeted peptide SS-31 ameliorates cardiomyopathy resulting from prolonged Ang stimulation as well as Gαq overexpression, suggesting its potential clinical application for target organ protection in hypertensive cardiovascular diseases.