L
Lukas Heger
Researcher at University of Erlangen-Nuremberg
Publications - 38
Citations - 790
Lukas Heger is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Immune system & Dendritic cell. The author has an hindex of 11, co-authored 30 publications receiving 458 citations. Previous affiliations of Lukas Heger include Innsbruck Medical University.
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Journal ArticleDOI
Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment
Gordon F. Heidkamp,Jil Sander,Christian H. K. Lehmann,Lukas Heger,Nathalie Eissing,Anna Baranska,Jennifer J. Lühr,Alana Hoffmann,Katharina C. Reimer,Anja Lux,Stephan Söder,Arndt Hartmann,Johannes Zenk,Thomas Ulas,Naomi McGovern,Christoph Alexiou,Bernd M. Spriewald,Andreas Mackensen,Gerold Schuler,Burkhard Schauf,Anja Forster,Roland Repp,Peter A. Fasching,Ariawan Purbojo,Robert Cesnjevar,Evelyn Ullrich,Evelyn Ullrich,Florent Ginhoux,Andreas Schlitzer,Andreas Schlitzer,Andreas Schlitzer,Falk Nimmerjahn,Joachim L. Schultze,Joachim L. Schultze,Diana Dudziak +34 more
TL;DR: It is demonstrated that DC subpopulations in organs of the lymphohematopoietic system (spleen, thymus, and blood) are strongly defined by ontogeny rather than by signals from the microenvironment, strongly arguing that DCs react toward modulatory signals from tissue microenvironments.
Journal ArticleDOI
CLEC10A Is a Specific Marker for Human CD1c+ Dendritic Cells and Enhances Their Toll-Like Receptor 7/8-Induced Cytokine Secretion.
Lukas Heger,Silke Balk,Jennifer J. Lühr,Gordon F. Heidkamp,Christian H. K. Lehmann,Lukas Hatscher,Ariawan Purbojo,Arndt Hartmann,Fayna Garcia-Martin,Shin-Ichiro Nishimura,Robert Cesnjevar,Falk Nimmerjahn,Diana Dudziak +12 more
TL;DR: CLEC10A represents not only a candidate to better define CD1c+ DCs—due to its high endocytic potential—but also exhibits an interesting candidate receptor for future antigen-targeting approaches.
Journal ArticleDOI
Direct Delivery of Antigens to Dendritic Cells via Antibodies Specific for Endocytic Receptors as a Promising Strategy for Future Therapies.
Christian H. K. Lehmann,Lukas Heger,Gordon F. Heidkamp,Anna Baranska,Anna Baranska,Jennifer J. Lühr,Alana Hoffmann,Diana Dudziak +7 more
TL;DR: The state-of-the-art aspects of the basic principles of antibody mediated antigen targeting approaches to DC subsets are discussed, including addressed DC subset, targeted receptors, outcome, and applied coupling techniques.
Journal ArticleDOI
Antigen delivery to CD11c+CD8- dendritic cells induces protective immune responses against experimental melanoma in mice in vivo.
Kirsten Neubert,Christian H. K. Lehmann,Lukas Heger,Anna Baranska,Anna Maria Staedtler,Veit R. Buchholz,Sayuri Yamazaki,Gordon F. Heidkamp,Nathalie Eissing,Henry Zebroski,Michel C. Nussenzweig,Falk Nimmerjahn,Diana Dudziak +12 more
TL;DR: It is demonstrated that Ag targeting to the CD11c+CD8− DC subpopulation in the presence of stimulating anti-CD40 Ab and TLR3 ligand polyinosinic-polycytidylic acid induces protective responses against rapidly growing tumor cells in naive animals under preventive and therapeutic treatment regimens in vivo.
Book ChapterDOI
Transcriptional control of dendritic cell development and functions.
TL;DR: Similarities, but also varieties, between human and murine DC subpopulations are challenging, and will require further investigation of human specimens under consideration of the influence of the tissue micromilieu and DC subset localization in the future.