L
Lukasz Jaremko
Researcher at King Abdullah University of Science and Technology
Publications - 32
Citations - 1228
Lukasz Jaremko is an academic researcher from King Abdullah University of Science and Technology. The author has contributed to research in topics: Biology & Protein aggregation. The author has an hindex of 11, co-authored 26 publications receiving 822 citations. Previous affiliations of Lukasz Jaremko include University of Wrocław & University of Warsaw.
Papers
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Journal ArticleDOI
NMR Spectroscopy for Metabolomics Research.
Abdul-Hamid M. Emwas,Raja Roy,Ryan T. McKay,Leonardo Tenori,Edoardo Saccenti,G. A. Nagana Gowda,Daniel Raftery,Daniel Raftery,Fatimah Alahmari,Lukasz Jaremko,Mariusz Jaremko,David S. Wishart +11 more
TL;DR: This review will highlight a number of emerging NMR techniques and technologies that are being used to strengthen its utility and overcome its inherent limitations in metabolomic applications.
Journal ArticleDOI
Structure of the Mitochondrial Translocator Protein in Complex with a Diagnostic Ligand
TL;DR: Three-dimensional high-resolution structure of mammalian TSPO reconstituted in detergent micelles in complex with its high-affinity ligand PK11195 suggests a molecular mechanism for the stimulation of cholesterol transport into mitochondria.
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Predictive atomic resolution descriptions of intrinsically disordered hTau40 and α-synuclein in solution from NMR and small angle scattering.
Martin Schwalbe,Valéry Ozenne,Valéry Ozenne,Stefan Bibow,Mariusz Jaremko,Lukasz Jaremko,Michal J. Gajda,Malene Ringkjøbing Jensen,Malene Ringkjøbing Jensen,Jacek Biernat,Stefan Becker,Eckhard Mandelkow,Markus Zweckstetter,Martin Blackledge,Martin Blackledge +14 more
TL;DR: Extensive cross-validation is shown that five different types of independent experimental parameters are predicted more accurately by selected ensembles than by statistical coil descriptions, suggesting that this region of conformational space is important for aggregation.
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Aggregation of biologically important peptides and proteins: inhibition or acceleration depending on protein and metal ion concentrations
Benjamin Gabriel Poulson,Kacper Szczepski,Joanna Izabela Lachowicz,Lukasz Jaremko,Abdul-Hamid M. Emwas,Mariusz Jaremko +5 more
TL;DR: This review focuses on the dependence of the aggregation of selected important biomolecules (peptides and proteins) on metal ion concentrations and reviews proteins that are prone to aggregation, the result of which can cause serious neurodegenerative disorders.
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NMR as a "Gold Standard" Method in Drug Design and Discovery.
Abdul-Hamid M. Emwas,Kacper Szczepski,Benjamin Gabriel Poulson,Kousik Chandra,Ryan T. McKay,Manel Dhahri,Fatimah Alahmari,Lukasz Jaremko,Joanna Izabela Lachowicz,Mariusz Jaremko +9 more
TL;DR: The major applications of NMR spectroscopy in medical drug discovery and development are presented and the basic concepts, theories, and applications of the most commonly used NMR techniques are presented.