L
Luz Delgado
Researcher at Andrés Bello National University
Publications - 7
Citations - 301
Luz Delgado is an academic researcher from Andrés Bello National University. The author has contributed to research in topics: Integrated stress response & ISRIB. The author has an hindex of 5, co-authored 7 publications receiving 214 citations.
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Journal ArticleDOI
Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model
John W. Steele,M. L. Lachenmayer,M. L. Lachenmayer,Shulin Ju,Aryeh Stock,J. Liken,Soong Ho Kim,Luz Delgado,Iván E. Alfaro,Sebastian Bernales,Giuseppe Verdile,Prashant Bharadwaj,Veer Bala Gupta,Renae Barr,A. Friss,Georgia Dolios,Rong Wang,Dagmar Ringe,Paul E. Fraser,David Westaway,P. St. George-Hyslop,Paul Szabo,Norman R. Relkin,Joseph D. Buxbaum,Charles G. Glabe,Charles G. Glabe,Andrew Asher Protter,Ralph N. Martins,Ralph N. Martins,Ralph N. Martins,Michelle E. Ehrlich,Gregory A. Petsko,Gregory A. Petsko,Zhenyu Yue,Sam Gandy,Sam Gandy +35 more
TL;DR: It is concluded that LAT possesses pro-autophagic properties in addition to the previously reported pro-neurogenic properties, both of which are potentially relevant to the treatment and/or prevention of neurodegenerative diseases.
Journal ArticleDOI
Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain
John W. Steele,Shulin Ju,M.L. Lachenmayer,M.L. Lachenmayer,J. Liken,Aryeh Stock,Soong Ho Kim,Luz Delgado,Iván E. Alfaro,Sebastian Bernales,Giuseppe Verdile,Prashant Bharadwaj,Veer Bala Gupta,Renae Barr,A. Friss,Georgia Dolios,Rong Wang,Dagmar Ringe,Andrew Asher Protter,Ralph N. Martins,Ralph N. Martins,Ralph N. Martins,Michelle E. Ehrlich,Zhenyu Yue,Gregory A. Petsko,Gregory A. Petsko,Sam Gandy,Sam Gandy +27 more
TL;DR: It is proposed that latrepirdine may represent a novel scaffold for discovery of robust pro-autophagic/anti-neurodegeneration compounds, which might yield clinical benefit for synucleinopathies including Parkinson's disease, Lewy body dementia, rapid eye movement (REM) sleep disorder and/or multiple system atrophy, following optimization of its pro- autophagic and pro-NEurogenic activities.
Journal ArticleDOI
Small molecule cognitive enhancer reverses age-related memory decline in mice.
Karen Krukowski,Amber Nolan,Elma S. Frias,Morgane Boone,Gonzalo Ureta,Katherine Grue,Maria-Serena Paladini,Edward Elizarraras,Luz Delgado,Sebastian Bernales,Peter Walter,Susanna Rosi +11 more
TL;DR: It is demonstrated that treatment with the drug-like small-molecule ISR inhibitor ISRIB reverses ISR activation in the brain, as indicated by decreased levels of activating transcription factor 4 (ATF4) and phosphorylated eukaryotic translation initiation factor eIF2, and treatment reverses spatial memory deficits and ameliorates working memory in old mice.
Peer ReviewDOI
Author response: Small molecule cognitive enhancer reverses age-related memory decline in mice
Karen Krukowski,Amber Nolan,Elma S. Frias,Morgane Boone,Gonzalo Ureta,Katherine Grue,Maria-Serena Paladini,Edward Elizarraras,Luz Delgado,Sebastian Bernales,Peter Walter,Susanna Rosi +11 more
Journal ArticleDOI
Integrated Stress Response Inhibitor Reverses Sex-Dependent Behavioral and Cell-Specific Deficits after Mild Repetitive Head Trauma
Karen Krukowski,Amber Nolan,Elma S. Frias,Katherine Grue,McKenna Becker,Gonzalo Ureta,Luz Delgado,Sebastian Bernales,Vikaas S. Sohal,Peter Walter,Susanna Rosi +10 more
TL;DR: It is reported that rTBI results in an increase in risk-taking behavior in male but not female mice and that targeting the ISR even at late time points after injury can permanently reverse behavioral changes.