L
Lynda Chin
Researcher at University of Texas MD Anderson Cancer Center
Publications - 127
Citations - 49829
Lynda Chin is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Melanoma & Cancer. The author has an hindex of 64, co-authored 126 publications receiving 40137 citations. Previous affiliations of Lynda Chin include Massachusetts Institute of Technology & Heidelberg University.
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Journal ArticleDOI
A Systems Biology Approach to Personalizing Therapeutic Combinations
TL;DR: A systematic approach to defining evidence-based, efficacious drug combinations for each cancer by molecularly benchmarking a drug against a desired state of efficacy using model systems is proposed.
Journal ArticleDOI
Downregulation of Protection of Telomeres 1 expression in myelodysplastic syndromes with 7q deletion.
Monica Cabrero,Yiting Yu,Amit Verma,Hui Yang,Simona Colla,Yu Jia,Hong Zheng,Zach Bohannan,Irene Ganan-Gomez,Andrew Futreal,Koichi Takahashi,Lynda Chin,Hagop M. Kantarjian,Andrea Pellagatti,Teresa V. Bowman,Jacqueline Boultwood,Guillermo Garcia-Manero,Yue Wei +17 more
TL;DR: Age, years Median 65 67 70 Range 34–86 22–88 33–90 Sex, n (%) Male 17 (57) NA 36 (64) Female 13 (43) NA 21 (36) Bone marrow blast, % Median 6 4 7 Range 1–26 0–20 1-26 WBC count, 910/l Median 3 3 8 3 Range 1-83 5 0 4–40 1–59 4 Haemoglobin, g/l median 100 96 100 Range 70
Proceedings ArticleDOI
Abstract A65: IACS-10759: A novel OXPHOS inhibitor that selectively kills tumors with metabolic vulnerabilities
Marina Protopopova,Madhavi Bandi,Yuting Sun,Jennifer Bardenhagen,Christopher A. Bristow,Christopher Carroll,Edward F. Chang,Ningping Feng,Mary Geck Do,Jennifer Greer,Marina Konopleva,Polina Matre,Zhijun Kang,Gang Liu,Florian L. Muller,Timothy Lofton,Timothy McAfoos,Melinda Smith,Jay Theroff,Jing Han,Yuanqing Wu,Lynda Chin,Giulio Draetta,Philip Jones,Carlo Toniatti,M. Emilia Di Francesco,Joseph R. Marszalek +26 more
TL;DR: In AML where tumor cells have been shown to be highly OXPHOS-dependent, IACS-10759 robustly suppresses cell growth and induces apoptosis in both primary AML samples and cell lines in vitro, but not in normal patient-derived bone marrow cells.
Journal ArticleDOI
Erratum: Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma (Nature Medicine (2012) 18 (1503-1510))
Lawrence N. Kwong,James C. Costello,Huiyun Liu,Shan Jiang,Timothy L. Helms,Aliete Langsdorf,David Jakubosky,Giannicola Genovese,Florian L. Muller,Joseph H. Jeong,Ryan P. Bender,Gerald C. Chu,Keith T. Flaherty,Jennifer A. Wargo,James J. Collins,Lynda Chin +15 more
TL;DR: In this paper, oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma, and differentiating between melanoma and other types of cancer, including lung cancer.
Journal ArticleDOI
Polygenic in vivo validation of cancer mutations using transposons
Su K.it Chew,Dong Lu,Dong Lu,Lia S. Campos,Kenneth L. Scott,Abdel Saci,Juexuan Wang,Adam Collinson,Adam Collinson,Keiran Raine,Jonathan Hinton,Jon W. Teague,David T. Jones,Andrew Menzies,Adam Butler,John Gamble,Sarah O’Meara,Stuart McLaren,Lynda Chin,Pentao Liu,P. Andrew Futreal,P. Andrew Futreal +21 more
TL;DR: A mouse model is described that allows multiple cancer mutations to be validated in each animal line using transposons, presenting a useful, generalised and efficient means for animal validation of cancer genes.