Lynda Chin

TL;DR: It is demonstrated that in vivo silencing of regulatable ΔEGFR with doxycycline attenuates glioma growth and that gliomas undergo selective pressure in vivo to employ alternative compensatory pathways to maintain aggressiveness in the event of EGFR silencing.

TL;DR: This inducible tumor model system permits the identification and validation of alternative points of therapeutic intervention without neutralization of the primary genetic lesion, and genetic complementation and interference studies demonstrated that this signaling loop is essential to H-RASV12G-directed tumorigenesis.

TL;DR: A systematic comparison of five copy number profiling assays for their ability to detect 2-fold copy number gain and loss as well as focal high-amplitude CNAs concluded that the Agilent's 60-mer oligonucleotide microarray with probe design optimized for genomic hybridization offers the highest sensitivity and specificity, whereas Affymetrix's single nucleotide polymorphism microarray seems to offer better detection of CNAs in gene-poor regions.

TL;DR: The results shed light on a mechanism that underlies genomic instability in sporadic cancers and suggest that inactivation of JARID1C in renal cancer leads to heterochromatin disruption, genomic rearrangement, and aggressive ccRCCs.

TL;DR: It is established that RNF2 is prognostic, exhibiting progression-correlated expression in human melanocytic neoplasms and oncogenic and prometastatic, and the notion that epigenetic regulators, such as R NF2, directly and functionally control powerful gene networks that are vital in multiple cancer processes is supported.