Lynda Chin

TL;DR: An unbiased and in vivo target discovery approach to identify molecular vulnerabilities in low-passage and patient-derived PDAC xenografts or genetically engineered mouse model-derived allOGrafts finds WDR5, a core member of the COMPASS histone H3 Lys4 (H3K4) MLL (1-4) methyltransferase complex, as a top tumor maintenance hit required across multiple human and mouse tumors.

TL;DR: It is demonstrated that loss of either Ink4a/Arf product can cooperate with RAS activation to produce clinically indistinguishable melanomas and that p16INK4a and p19ARF cooperate to suppress the development of melanoma in vivo.

TL;DR: Comparison of balanced-PCR with multiple displacement amplification (MDA) demonstrates equivalent performance between the two when intact genomic DNA is used, and balanced PCR overcomes problems associated with modest DNA degradation and produces unbiased amplification whereas MDA does not.

TL;DR: It is found that circular assemblies are the most parsimonious explanation for a set of highly amplified tumor regions in a subset of glioblastoma multiforme samples sequenced by The Cancer Genome Atlas consortium, revealing evidence for double minute chromosomes in these tumors.