L
Lynda Chin
Researcher at University of Texas MD Anderson Cancer Center
Publications - 127
Citations - 49829
Lynda Chin is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Melanoma & Cancer. The author has an hindex of 64, co-authored 126 publications receiving 40137 citations. Previous affiliations of Lynda Chin include Massachusetts Institute of Technology & Heidelberg University.
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Journal ArticleDOI
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
Haoqiang Ying,Alec C. Kimmelman,Costas A. Lyssiotis,Sujun Hua,Gerald C. Chu,Eliot Fletcher-Sananikone,Jason W. Locasale,Jaekyoung Son,Hailei Zhang,Jonathan L. Coloff,Haiyan Yan,Wei Wang,Shujuan Chen,Andrea Viale,Hongwu Zheng,Jihye Paik,Carol Lim,Alexander R. Guimaraes,Eric S. Martin,Jeffery Chang,Aram F. Hezel,Samuel R. Perry,Jian Hu,Boyi Gan,Yonghong Xiao,John M. Asara,Ralph Weissleder,Y. Alan Wang,Lynda Chin,Lewis C. Cantley,Ronald A. DePinho +30 more
TL;DR: In vivo mechanistic insights are provided into how oncogenic Kras promotes metabolic reprogramming in native tumors and illuminates potential metabolic targets that can be exploited for therapeutic benefit in PDAC.
Journal ArticleDOI
Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer.
Giovanni Ciriello,Giovanni Ciriello,Michael L. Gatza,Michael L. Gatza,Andrew H. Beck,Matthew D. Wilkerson,Suhn K. Rhie,Alessandro Pastore,Hailei Zhang,Michael D. McLellan,Christina Yau,Cyriac Kandoth,Reanne Bowlby,Hui Shen,Sikander Hayat,Robert J. Fieldhouse,Susan C. Lester,Gary M. Tse,Rachel E. Factor,Laura C. Collins,Kimberly H. Allison,Yunn Yi Chen,Kristin C. Jensen,Kristin C. Jensen,Nicole B. Johnson,Steffi Oesterreich,Gordon B. Mills,Andrew D. Cherniack,Gordon Robertson,Christopher C. Benz,Chris Sander,Peter W. Laird,Katherine A. Hoadley,Tari A. King,Rehan Akbani,J. Todd Auman,Miruna Balasundaram,Saianand Balu,Thomas Barr,Stephen C. Benz,Mario Berrios,Rameen Beroukhim,Tom Bodenheimer,Lori Boice,Moiz S. Bootwalla,Jay Bowen,Denise Brooks,Lynda Chin,Juok Cho,Sudha Chudamani,Tanja M. Davidsen,John A. Demchok,Jennifer B. Dennison,Li Ding,Ina Felau,Martin L. Ferguson,Scott Frazer,Stacey Gabriel,Jianjiong Gao,Julie M. Gastier-Foster,Nils Gehlenborg,Mark Gerken,Gad Getz,William J. Gibson,D. Neil Hayes,David I. Heiman,Andrea Holbrook,Robert A. Holt,Alan P. Hoyle,Hai Hu,Mei Huang,Carolyn M. Hutter,E. Shelley Hwang,Stuart R. Jefferys,Steven J.M. Jones,Zhenlin Ju,Jaegil Kim,Phillip H. Lai,Michael S. Lawrence,Kristen M. Leraas,Tara M. Lichtenberg,Pei Lin,Shiyun Ling,Jia Liu,Wen-Bin Liu,Laxmi Lolla,Yiling Lu,Yussanne Ma,Dennis T. Maglinte,Elaine R. Mardis,Jeffrey R. Marks,Marco A. Marra,Cynthia McAllister,Shaowu Meng,Matthew Meyerson,Richard A. Moore,Lisle E. Mose,Andrew J. Mungall,Bradley A. Murray,Rashi Naresh,Michael S. Noble,Olufunmilayo I. Olopade,Joel S. Parker,Todd Pihl,Gordon Saksena,Steven E. Schumacher,Kenna R. Mills Shaw,Nilsa C. Ramirez,W. Kimryn Rathmell,Jeffrey Roach,A. Gordon Robertson,Jacqueline E. Schein,Nikolaus Schultz,Margi Sheth,Yan Shi,Juliann Shih,Carl Simon Shelley,Craig D. Shriver,Janae V. Simons,Heidi J. Sofia,Matthew G. Soloway,Carrie Sougnez,Charlie Sun,Roy Tarnuzzer,Daniel Guimarães Tiezzi,David Van Den Berg,Doug Voet,Yunhu Wan,Zhining Wang,John N. Weinstein,Daniel J. Weisenberger,Rick K. Wilson,Lisa Wise,Maciej Wiznerowicz,Junyuan Wu,Ye Wu,Liming Yang,Travis I. Zack,Jean C. Zenklusen,Jiashan Zhang,Erik Zmuda,Charles M. Perou +141 more
TL;DR: This multidimensional molecular atlas sheds new light on the genetic bases of ILC and provides potential clinical options, suggesting differential modulation of ER activity in I LC and IDC.
Journal ArticleDOI
Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma
Benjamin J. Raphael,Ralph H. Hruban,Andrew J. Aguirre,Richard A. Moffitt,Jen Jen Yeh,Chip Stewart,A. Gordon Robertson,Andrew D. Cherniack,Manaswi Gupta,Gad Getz,Stacey Gabriel,Matthew Meyerson,Carrie Cibulskis,Suzanne S. Fei,Toshinori Hinoue,Hui Shen,Peter W. Laird,Shiyun Ling,Yiling Lu,Gordon B. Mills,Rehan Akbani,Phillipe Loher,Eric Londin,Isidore Rigoutsos,Aristeidis G. Telonis,Ewan A. Gibb,Anna Goldenberg,Aziz M. Mezlini,Katherine A. Hoadley,Eric A. Collisson,Eric S. Lander,Bradley A. Murray,Julian M. Hess,Mara Rosenberg,Louis Bergelson,Hailei Zhang,Juok Cho,Grace Tiao,Jaegil Kim,Dimitri Livitz,Ignaty Leshchiner,Brendan Reardon,Eliezer M. Van Allen,Atanas Kamburov,Rameen Beroukhim,Gordon Saksena,Steven E. Schumacher,Michael S. Noble,David I. Heiman,Nils Gehlenborg,Michael S. Lawrence,Volkan Adsay,Gloria M. Petersen,David S. Klimstra,Nabeel Bardeesy,Mark D.M. Leiserson,Reanne Bowlby,Katayoon Kasaian,Inanc Birol,Karen Mungall,Sara Sadeghi,John N. Weinstein,Paul T. Spellman,Yuexin Liu,Laufey T. Amundadottir,Joel E. Tepper,Aatur D. Singhi,Rajiv Dhir,Drwiega Paul,Thomas C. Smyrk,Lizhi Zhang,Paula Kim,Jay Bowen,Jessica Frick,Julie M. Gastier-Foster,Mark Gerken,Kevin Lau,Kristen M. Leraas,Tara M. Lichtenberg,Nilsa C. Ramirez,Jeremy Renkel,Mark E. Sherman,Lisa Wise,Peggy Yena,Erik Zmuda,Juliann Shih,Adrian Ally,Miruna Balasundaram,Rebecca Carlsen,Andy Chu,Eric Chuah,Amanda Clarke,Noreen Dhalla,Robert A. Holt,Steven J.M. Jones,Darlene Lee,Yussanne Ma,Marco A. Marra,Michael Mayo,Richard A. Moore,Andrew J. Mungall,Jacqueline E. Schein,Payal Sipahimalani,Angela Tam,Nina Thiessen,Kane Tse,Tina Wong,Denise Brooks,J. Todd Auman,Saianand Balu,Tom Bodenheimer,D. Neil Hayes,Alan P. Hoyle,Stuart R. Jefferys,Corbin D. Jones,Shaowu Meng,Piotr A. Mieczkowski,Lisle E. Mose,Charles M. Perou,Amy H. Perou,Jeffrey Roach,Yan Shi,Janae V. Simons,Tara Skelly,Matthew G. Soloway,Donghui Tan,Umadevi Veluvolu,Joel S. Parker,Matthew D. Wilkerson,Anil Korkut,Yasin Senbabaoglu,Patrick Burch,Robert R. McWilliams,Kari G. Chaffee,Ann L. Oberg,Wei Zhang,Marie-Claude Gingras,David A. Wheeler,Liu Xi,Monique Albert,John M. S. Bartlett,Harman Sekhon,Yeager Stephen,Zaren Howard,Miller Judy,Anne Breggia,Rachna T. Shroff,Sudha Chudamani,Jia Liu,Laxmi Lolla,Rashi Naresh,Todd Pihl,Qiang Sun,Yunhu Wan,Ye Wu,Smith Jennifer,Kevin Roggin,Karl-Friedrich Becker,Madhusmita Behera,Joseph J. Bennett,Lori Boice,Eric J. Burks,Carlos Gilberto Carlotti Junior,John Chabot,Daniela Pretti da Cunha Tirapelli,Jose Sebastião dos Santos,Michael Dubina,Jennifer M. Eschbacher,Mei Huang,Lori Huelsenbeck-Dill,Roger Jenkins,Alexey Karpov,Rafael Kemp,Vladimir Lyadov,Shishir K. Maithel,Georgy Manikhas,Eric Montgomery,Houtan Noushmehr,Adeboye O. Osunkoya,Taofeek K. Owonikoko,Oxana Paklina,Olga Potapova,Suresh S. Ramalingam,W. Kimryn Rathmell,Kimberly M. Rieger-Christ,Charles Saller,Galiya Setdikova,Alexey Shabunin,Gabriel Sica,Tao Su,Travis Sullivan,Pat Swanson,Katherine Tarvin,Michael Tavobilov,Leigh B. Thorne,Stefan Urbanski,Olga Voronina,Timothy C. Wang,Daniel Crain,Erin Curley,Johanna Gardner,David Mallery,Scott J. Morris,Joseph Paulauskis,Robert Penny,Candace Shelton,Troy Shelton,Klaus-Peter Janssen,Oliver F. Bathe,Nathan Bahary,Julia Slotta-Huspenina,Amber L. Johns,Hanina Hibshoosh,Rosa F. Hwang,Antonia R. Sepulveda,Amie Radenbaugh,Stephen B. Baylin,Mario Berrios,Moiz S. Bootwalla,Andrea Holbrook,Phillip H. Lai,Dennis T. Maglinte,Swapna Mahurkar,Timothy J. Triche,David Van Den Berg,Daniel J. Weisenberger,Lynda Chin,Raju Kucherlapati,Melanie H. Kucherlapati,Angeliki Pantazi,Peter J. Park,Doug Voet,Pei Lin,Scott Frazer,Timothy Defreitas,Sam Meier,Sun Young Kwon,Yong Hoon Kim,Sang Jae Park,Sung Sik Han,Seong Hoon Kim,Hark Kyun Kim,Emma E. Furth,Margaret A. Tempero,Chris Sander,Andrew V. Biankin,David K. Chang,Peter Bailey,Anthony J. Gill,James G. Kench,Sean M. Grimmond,Russell Postier,Rosemary E. Zuna,Hugues Sicotte,John A. Demchok,Martin L. Ferguson,Carolyn M. Hutter,Kenna R. Mills Shaw,Margi Sheth,Heidi J. Sofia,Roy Tarnuzzer,Zhining Wang,Liming Yang,Jiashan Zhang,Ina Felau,Jean C. Zenklusen +265 more
TL;DR: An integrated multi-platform analysis of 150 pancreatic ductal adenocarcinoma specimens reveals a complex molecular landscape of PDAC and provides a roadmap for precision medicine.
Journal ArticleDOI
The genomic complexity of primary human prostate cancer
Michael F. Berger,Michael F. Berger,Michael S. Lawrence,Francesca Demichelis,Yotam Drier,Kristian Cibulskis,Andrey Sivachenko,Andrea Sboner,Raquel Esgueva,Dorothee Pflueger,Carrie Sougnez,Robert C. Onofrio,Scott L. Carter,Kyung Park,Lukas Habegger,Lauren Ambrogio,Timothy Fennell,Melissa Parkin,Gordon Saksena,Douglas Voet,Alex H. Ramos,Alex H. Ramos,Trevor J. Pugh,Trevor J. Pugh,Jane Wilkinson,Sheila Fisher,Wendy Winckler,Scott Mahan,Kristin G. Ardlie,Jennifer Baldwin,Jonathan W. Simons,Naoki Kitabayashi,Theresa Y. MacDonald,Philip W. Kantoff,Lynda Chin,Stacey Gabriel,Mark Gerstein,Todd R. Golub,Todd R. Golub,Todd R. Golub,Matthew Meyerson,Matthew Meyerson,Ashutosh Tewari,Eric S. Lander,Eric S. Lander,Eric S. Lander,Gad Getz,Mark A. Rubin,Levi A. Garraway,Levi A. Garraway +49 more
TL;DR: In this paper, the authors presented the complete sequence of seven primary human prostate cancers and their paired normal counterparts and revealed previously unknown balanced rearrangements, at which multiple intra-and inter-chromosomal loci exchange their breakpoint arms without any loss of genetic material.
Journal ArticleDOI
Identification of Double Stranded Genomic DNA Spanning all Chromosomes with Mutated KRAS and p53 DNA in the Serum Exosomes of Patients with Pancreatic Cancer
Christoph Kahlert,Christoph Kahlert,Sonia A. Melo,Alexei Protopopov,Jiabin Tang,Sahil Seth,Moritz Koch,Jianhua Zhang,Juergen Weitz,Lynda Chin,Lynda Chin,Andrew Futreal,Raghu Kalluri +12 more
TL;DR: The results indicate that serum-derived exosomes can be used to determine genomic DNA mutations for cancer prediction, treatment, and therapy resistance.