Open AccessJournal Article
Inhibitory and Stimulatory Effects of IL-10 on Human CD8+ T Cells
TLDR
It is reported that IL-10 inhibits alloantigen-specific proliferative responses and induces a long lasting anergic state in human purified CD8+ T cells when added concomitantly with the Ag in the presence of APC, and the generation of allospecific cytotoxic activity is inhibited byIL-10.Abstract:
IL-10 is a well-documented immunosuppressant that inhibits macrophage-dependent Ag presentation and CD4+ T cell proliferation in vitro. We report that IL-10 inhibits alloantigen-specific proliferative responses and induces a long lasting anergic state in human purified CD8+ T cells when added concomitantly with the Ag in the presence of APC. Moreover, the generation of allospecific cytotoxic activity is inhibited by IL-10. These effects are indirect and are mediated through inhibition of the costimulatory functions of APC. In contrast, IL-10 has no direct inhibitory effects on the proliferation of purified CD8+ T cells activated by anti-CD3 mAb and promotes the growth of activated CD8+ T cells in combination with low doses of IL-2. Taken together, these results indicate that IL-10 has differential effects on CD8+ T cells depending on their state of activation, which may explain both the enhancing and inhibitory effects observed after IL-10 treatment in different in vivo experimental models.read more
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References
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Journal ArticleDOI
Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.
TL;DR: The results indicate that IL-10 has important regulatory effects on immunological and inflammatory responses because of its capacity to downregulate class II MHC expression and to inhibit the production of proinflammatory cytokines by monocytes.
Journal Article
IL-10 inhibits cytokine production by activated macrophages.
TL;DR: The potent action of IL-10 on the macrophage, particularly at the level of monokine production, supports an important role for this cytokine not only in the regulation of T cell responses but also in acute inflammatory responses.
Journal ArticleDOI
Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.
R de Waal Malefyt,John B. A. G. Haanen,H Spits,M G Roncarolo,A.A. te Velde,Carl G. Figdor,K E Johnson,Rob A. Kastelein,Hans Yssel,J E de Vries +9 more
TL;DR: It is indicated that IL-10 and v-IL-10 can completely prevent antigen-specific T cell proliferation by inhibition of the antigen-presenting capacity of monocytes through downregulation of class II MHC antigens on monocytes.
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IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.
David Fiorentino,Albert Zlotnik,Pedro L. Vieira,Tim R. Mosmann,M Howard,Kevin W. Moore,Anne O'Garra +6 more
TL;DR: IL-10 may inhibit macrophage accessory cell function which is independent of TCR-class II MHC interactions, as well as inhibits IL-2-induced IFN-gamma production by Th1 cells in an Ag-free system requiring only the presence of accessory cells.
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Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.
Françoise Rousset,Eric Garcia,Thierry Defrance,Catherine Peronne,Nadia Vezzio,Di-Hwei Hsu,Rob Kastelein,Kevin W. Moore,Jacques Banchereau +8 more
TL;DR: It is shown that human and viral IL-10 stimulate DNA replication of B lymphocytes activated either via their antigen receptor or via their CD40 antigen, and the combination ofIL-10 and IL-4 results in the secretion of the four immunoglobulin isotypes.