M
M. Emmer
Researcher at Erasmus University Rotterdam
Publications - 41
Citations - 3347
M. Emmer is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Microbubbles & Drug delivery. The author has an hindex of 19, co-authored 41 publications receiving 3128 citations. Previous affiliations of M. Emmer include Philips & University of Twente.
Papers
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Journal ArticleDOI
A model for large amplitude oscillations of coated bubbles accounting for buckling and rupture
Philippe Marmottant,Philippe Marmottant,Sander van der Meer,M. Emmer,Michel Versluis,Nico de Jong,Nico de Jong,Sascha Hilgenfeldt,Sascha Hilgenfeldt,Detlef Lohse +9 more
TL;DR: In this paper, the authors present a model applicable to ultrasound contrast agent bubbles that takes into account the physical properties of a lipid monolayer coating on a gas microbubble, including buckling radius, the compressibility of the shell, and a break-up shell tension.
Journal ArticleDOI
Vibrating microbubbles poking individual cells: drug transfer into cells via sonoporation.
Annemieke van Wamel,Klazina Kooiman,Miranda Harteveld,M. Emmer,Folkert J. ten Cate,Michel Versluis,Nico de Jong,Nico de Jong +7 more
TL;DR: It is identified that microbubbles are crucial to enhance transient cell membrane permeability and permeability of individual cells is increased.
Proceedings Article
A model for large amplitude oscillations of coated bubbles accounting for buckling and rupture
Philippe Marmottant,S.M. van der Meer,M. Emmer,Michel Versluis,N. de Jong,Sascha Hilgenfeldt,Detlef Lohse +6 more
TL;DR: In this paper, a model applicable to ultrasound contrast agent bubbles that takes into account the physical properties of a lipid monolayer coating on a gas microbubble is presented. But it does not consider the effect of aging, or the resultant of repeated acoustic pressure pulses on bubbles.
Journal ArticleDOI
Ultrasound and Microbubble-Targeted Delivery of Macromolecules Is Regulated by Induction of Endocytosis and Pore Formation
Bernadet D. M. Meijering,Lynda J. M. Juffermans,Annemieke van Wamel,Robert H. Henning,Inge S. Zuhorn,M. Emmer,Amanda M. G. Versteilen,Walter Paulus,Wiek H. van Gilst,Klazina Kooiman,Nico de Jong,René J. P. Musters,Leo E. Deelman,Otto Kamp +13 more
TL;DR: In addition to triggering endocytosis, UMTD also evoked transient pore formation, as demonstrated by the influx of calcium ions and cellular release of preloaded dextrans after US and microbubble exposure.
Journal ArticleDOI
"Compression-only" behavior of phospholipid-coated contrast bubbles.
Nico de Jong,Nico de Jong,M. Emmer,Chien Ting Chin,Ayache Bouakaz,Frits Mastik,Detlef Lohse,Michel Versluis +7 more
TL;DR: The observation of a highly nonlinear response of phospholipid-coated contrast agents at pressures as low as 50 kPa, termed "compression-only" behavior, where the microbubbles only compress, yet hardly expand is reported.