K
Klazina Kooiman
Researcher at Erasmus University Rotterdam
Publications - 91
Citations - 3051
Klazina Kooiman is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Microbubbles & Sonoporation. The author has an hindex of 23, co-authored 82 publications receiving 2501 citations. Previous affiliations of Klazina Kooiman include University of Pittsburgh & Leiden University.
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Journal ArticleDOI
Vibrating microbubbles poking individual cells: drug transfer into cells via sonoporation.
Annemieke van Wamel,Klazina Kooiman,Miranda Harteveld,M. Emmer,Folkert J. ten Cate,Michel Versluis,Nico de Jong,Nico de Jong +7 more
TL;DR: It is identified that microbubbles are crucial to enhance transient cell membrane permeability and permeability of individual cells is increased.
Journal ArticleDOI
Ultrasound and Microbubble-Targeted Delivery of Macromolecules Is Regulated by Induction of Endocytosis and Pore Formation
Bernadet D. M. Meijering,Lynda J. M. Juffermans,Annemieke van Wamel,Robert H. Henning,Inge S. Zuhorn,M. Emmer,Amanda M. G. Versteilen,Walter Paulus,Wiek H. van Gilst,Klazina Kooiman,Nico de Jong,René J. P. Musters,Leo E. Deelman,Otto Kamp +13 more
TL;DR: In addition to triggering endocytosis, UMTD also evoked transient pore formation, as demonstrated by the influx of calcium ions and cellular release of preloaded dextrans after US and microbubble exposure.
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Acoustic behavior of microbubbles and implications for drug delivery
TL;DR: Phenomena relevant to drug delivery, such as non-spherical oscillations, shear stress, microstreaming, and jetting will be reviewed from both a theoretical and experimental perspective.
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Ultrasound-Responsive Cavitation Nuclei for Therapy and Drug Delivery
Klazina Kooiman,Silke Roovers,Simone A.G. Langeveld,Robert T. Kleven,Heleen Dewitte,Meaghan A. O'Reilly,Jean-Michel Escoffre,Ayache Bouakaz,Martin D. Verweij,Kullervo Hynynen,Ine Lentacker,Eleanor Stride,Christy K. Holland +12 more
TL;DR: This review summarizes recent investigations that have elucidated interactions of ultrasound and cavitation nuclei with cells, the treatment of tumors, immunotherapy, the blood–brain and blood–spinal cord barriers, sonothrombolysis, cardiovascular drug delivery and sonobactericide.
Journal ArticleDOI
Sonoporation of endothelial cells by vibrating targeted microbubbles.
Klazina Kooiman,Miranda Foppen-Harteveld,Antonius F.W. van der Steen,Nico de Jong,Nico de Jong +4 more
TL;DR: Targeted microbubbles can also be used to induce sonoporation, thus making it possible to combine molecular imaging and drug delivery, and no relationship was found between the position of the microbubble on the cell and induction of soniporation.