M
Madigan L. Bedard
Researcher at University of Pennsylvania
Publications - 4
Citations - 43
Madigan L. Bedard is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Neurofibrillary tangle & Human brain. The author has an hindex of 1, co-authored 4 publications receiving 7 citations.
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Journal ArticleDOI
Three-dimensional mapping of neurofibrillary tangle burden in the human medial temporal lobe
Paul A. Yushkevich,M. López,Maria Mercedes Iniguez de Onzono Martin,Ranjit Ittyerah,Sydney Lim,Sadhana Ravikumar,Madigan L. Bedard,Stephen Pickup,Weixia Liu,Jiancong Wang,Ling Yu Hung,Jade Lasserve,Nicolas Vergnet,Long Xie,Mengjin Dong,Salena Cui,Lauren McCollum,John L. Robinson,Theresa Schuck,Robin de Flores,Murray Grossman,M. Dylan Tisdall,Karthik Prabhakaran,Gabor Mizsei,Sandhitsu R. Das,Emilio Artacho-Pérula,María del Mar Arroyo Jiménez,Marı’a Pilar Marcos Raba,Francisco Javier Molina Romero,Sandra Cebada Sánchez,José Carlos Delgado González,Carlos de la Rosa-Prieto,Marta Córcoles Parada,Edward B. Lee,John Q. Trojanowski,Daniel T. Ohm,Laura Wisse,David A. Wolk,David J. Irwin,Ricardo Insausti +39 more
TL;DR: In this paper, the authors constructed 3D quantitative maps of neurofibrillary tangle burden in the medial temporal lobe at individual and group levels and found significant variation along the anterior-posterior axis.
Journal ArticleDOI
Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology.
Sadhana Ravikumar,Laura E.M. Wisse,Laura E.M. Wisse,Sydney Lim,Ranjit Ittyerah,Long Xie,Madigan L. Bedard,Sandhitsu R. Das,Edward B. Lee,M. Dylan Tisdall,Karthik Prabhakaran,Jacqueline M. Lane,John A. Detre,Gabor Mizsei,John Q. Trojanowski,John L. Robinson,Theresa Schuck,Murray Grossman,Emilio Artacho-Pérula,Maria Mercedes Iniguez de Onzono Martin,María del Mar Arroyo Jiménez,Monica Munoz,Francisco Javier Molina Romero,Maria del Pilar Marcos Rabal,Sandra Cebada Sánchez,José Carlos Delgado González,Carlos de la Rosa Prieto,Marta Córcoles Parada,David J. Irwin,David A. Wolk,Ricardo Insausti,Paul A. Yushkevich +31 more
TL;DR: In this article, the authors compared high-resolution ex vivo MRI scans of human postmortem medial temporal lobe (MTL) specimens with histology-based pathological assessments of the MTL and found significant correlations between tau pathology and thickness in the entorhinal cortex and stratum radiatum lacunosum moleculare (SRLM).
Posted ContentDOI
3D Mapping of Neurofibrillary Tangle Burden in the Human Medial Temporal Lobe
Paul A. Yushkevich,M. López,Maria Mercedes Iniguez de Onzono Martin,Ranjit Ittyerah,Sydney Lim,Sadhana Ravikumar,Madigan L. Bedard,Stephen Pickup,Weixia Liu,Jiancong Wang,Ling Yu Hung,Jade Lasserve,Nicolas Vergnet,Long Xie,Mengjin Dong,Salena Cui,Lauren McCollum,John L. Robinson,Theresa Schuck,Robin de Flores,Murray Grossman,M. Dylan Tisdall,Karthik Prabhakaran,Gabor Mizsei,Sandhitsu R. Das,Emilio Artacho-Pérula,María del Mar Arroyo Jiménez,Maria del Pilar Marcos Rabal,Francisco Javier Molina Romero,Sandra Cebada Sánchez,José Carlos Delgado González,Carlos de la Rosa-Prieto,Marta Córcoles Parada,Edward B. Lee,John Q. Trojanowski,Daniel T. Ohm,Laura Wisse,David A. Wolk,David J. Irwin,Ricardo Insausti +39 more
TL;DR: In this paper, the authors used ex vivo MRI and dense serial histological imaging in 18 human medial temporal lobe (MTL) specimens to construct 3D quantitative maps of NFT burden in the MTL at individual and group levels.
Posted Content
Gray Matter Segmentation in Ultra High Resolution 7 Tesla ex vivo T2w MRI of Human Brain Hemispheres.
Pulkit Khandelwal,Shokufeh Sadaghiani,Sadhana Ravikumar,Sydney Lim,Sanaz Arezoumandan,Claire Peterson,Eunice Chung,Madigan L. Bedard,Noah Capp,Ranjit Ittyerah,Elyse Migdal,Grace Choi,Emily Kopp,Bridget Loja,Eusha Hasan,Jiacheng Li,Karthik Prabhakaran,Gabor Mizsei,Marianna Gabrielyan,Theresa Schuck,John L. Robinson,Daniel T. Ohm,Edward B. Lee,John Q. Trojanowski,Corey T. McMillan,Murray Grossman,David J. Irwin,M. Dylan Tisdall,Sandhitsu R. Das,Laura E.M. Wisse,David A. Wolk,Paul A. Yushkevich +31 more
TL;DR: Khandelwal et al. as mentioned in this paper presented a high resolution 7 Tesla dataset of 32 ex vivo human brain specimens and compared nine neural network architectures with manually-segmented 3D patches sampled from specific cortical regions.