S
Sadhana Ravikumar
Researcher at University of Pennsylvania
Publications - 12
Citations - 78
Sadhana Ravikumar is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Neurofibrillary tangle & Temporal lobe. The author has an hindex of 3, co-authored 12 publications receiving 19 citations.
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Journal ArticleDOI
Three-dimensional mapping of neurofibrillary tangle burden in the human medial temporal lobe
Paul A. Yushkevich,M. López,Maria Mercedes Iniguez de Onzono Martin,Ranjit Ittyerah,Sydney Lim,Sadhana Ravikumar,Madigan L. Bedard,Stephen Pickup,Weixia Liu,Jiancong Wang,Ling Yu Hung,Jade Lasserve,Nicolas Vergnet,Long Xie,Mengjin Dong,Salena Cui,Lauren McCollum,John L. Robinson,Theresa Schuck,Robin de Flores,Murray Grossman,M. Dylan Tisdall,Karthik Prabhakaran,Gabor Mizsei,Sandhitsu R. Das,Emilio Artacho-Pérula,María del Mar Arroyo Jiménez,Marı’a Pilar Marcos Raba,Francisco Javier Molina Romero,Sandra Cebada Sánchez,José Carlos Delgado González,Carlos de la Rosa-Prieto,Marta Córcoles Parada,Edward B. Lee,John Q. Trojanowski,Daniel T. Ohm,Laura Wisse,David A. Wolk,David J. Irwin,Ricardo Insausti +39 more
TL;DR: In this paper, the authors constructed 3D quantitative maps of neurofibrillary tangle burden in the medial temporal lobe at individual and group levels and found significant variation along the anterior-posterior axis.
Journal ArticleDOI
Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology.
Sadhana Ravikumar,Laura E.M. Wisse,Laura E.M. Wisse,Sydney Lim,Ranjit Ittyerah,Long Xie,Madigan L. Bedard,Sandhitsu R. Das,Edward B. Lee,M. Dylan Tisdall,Karthik Prabhakaran,Jacqueline M. Lane,John A. Detre,Gabor Mizsei,John Q. Trojanowski,John L. Robinson,Theresa Schuck,Murray Grossman,Emilio Artacho-Pérula,Maria Mercedes Iniguez de Onzono Martin,María del Mar Arroyo Jiménez,Monica Munoz,Francisco Javier Molina Romero,Maria del Pilar Marcos Rabal,Sandra Cebada Sánchez,José Carlos Delgado González,Carlos de la Rosa Prieto,Marta Córcoles Parada,David J. Irwin,David A. Wolk,Ricardo Insausti,Paul A. Yushkevich +31 more
TL;DR: In this article, the authors compared high-resolution ex vivo MRI scans of human postmortem medial temporal lobe (MTL) specimens with histology-based pathological assessments of the MTL and found significant correlations between tau pathology and thickness in the entorhinal cortex and stratum radiatum lacunosum moleculare (SRLM).
Journal ArticleDOI
Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions.
Laura E.M. Wisse,Laura E.M. Wisse,Sadhana Ravikumar,Ranjit Ittyerah,Sydney Lim,Jacqueline M. Lane,M L Bedard,Long Xie,Sandhitsu R. Das,Theresa Schuck,Murray Grossman,Edward B. Lee,M. D. Tisdall,Karthik Prabhakaran,John A. Detre,Gabor Mizsei,John Q. Trojanowski,Emilio Artacho-Pérula,M M de Iñiguez de Onzono Martin,Maria del Mar Arroyo-Jimenez,M Muñoz Lopez,F J Molina Romero,M P Marcos Rabal,S Cebada Sánchez,J C Delgado González,C de la Rosa Prieto,M Córcoles Parada,David A. Wolk,David J. Irwin,Ricardo Insausti,Paul A. Yushkevich +30 more
TL;DR: In this article, the authors investigated associations between neurodegenerative pathologies and the thickness of different medial temporal lobe (MTL) subregions measured using high-resolution post-mortem MRI.
Proceedings ArticleDOI
Facilitating Manual Segmentation of 3D Datasets Using Contour And Intensity Guided Interpolation
TL;DR: A two-step interpolation approach that utilizes a “binary weighted averaging” algorithm to interpolate contour information, and the random forest framework to perform intensity-based label classification is proposed.
Proceedings ArticleDOI
3D Mapping of TAU Neurofibrillary Tangle Pathology in the Human Medial Temporal Lobe
Paul A. Yushkevich,Maria Mercedes Iniguez de Onzono Martin,Ranjit Ittyerah,Sydney Lim,Madigan Lavery,Jiancong Wang,Ling Yu Hung,Nicolas Vergnet,Sadhana Ravikumar,Long Xie,Mengjin Dong,Robin DeFlores,Salena Cui,Lauren McCollum,Daniel T. Ohm,John L. Robinson,Theresa Schuck,Murray Grossman,M. Dylan Tisdall,Karthik Prabhakaran,Gabor Mizsei,Sandhitsu R. Das,Emilio Artacho-Pérula,María del Mar Arroyo Jiménez,Monica Munoz Lopez,Maria del Pilar Marcos Rabal,Francisco Javier Molina Romero,Edward B. Lee,John Q. Trojanowski,Laura E.M. Wisse,David A. Wolk,David J. Irwin,Ricardo Insausti +32 more
TL;DR: A computational framework for generating 3D maps of NFT load from ex vivo MRI and serial histology is presented, which are strongly concordant with manual NFT counting, as well as categorical NFT severity ratings used for clinical diagnosis.