Israel Cañadas

TL;DR: A resistance program expressed by malignant cells that is associated with T cell exclusion and immune evasion is identified, and this study provides a high-resolution landscape of ICI-resistant cell states, identifies clinically predictive signatures, and suggests new therapeutic strategies to overcome immunotherapy resistance.

TL;DR: The ability to interrogate ex vivo response to PD-1 blockade using murine- and patient-derived organotypic tumor spheroids (MDOTS/PDOTS) is demonstrated, which represents a novel platform to evaluate ICB using established murine models as well as clinically relevant patient specimens.

TL;DR: Colorectal tumors evade EGFR blockade by constitutive activation of downstream signaling effectors and through mutations affecting receptor–antibody binding through mechanisms of resistance to cetuximab, which may occur concomitantly.

TL;DR: A subclass of endogenous retroviruses (ERVs) whose derepression triggers pathologic innate immune signaling in cancer, with important implications for cancer immunotherapy is identified.

TL;DR: A significant frequency of ALK amplification and its association with EGFR FISH positivity in lung adenocarcinomas is revealed and EML4-ALK translocation is a rare event in NSCLC.