M
Mei-Ju Su
Researcher at Harvard University
Publications - 13
Citations - 2247
Mei-Ju Su is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Immune system. The author has an hindex of 8, co-authored 13 publications receiving 1037 citations. Previous affiliations of Mei-Ju Su include Northeastern University & Broad Institute.
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Journal ArticleDOI
A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade
Livnat Jerby-Arnon,Parin Shah,Michael S. Cuoco,Christopher Rodman,Mei-Ju Su,Johannes C. Melms,Rachel Leeson,Abhay Kanodia,Shaolin Mei,Jia-Ren Lin,Shu Wang,Bokang Rabasha,David Liu,Gao Zhang,Claire Margolais,Orr Ashenberg,Patrick A. Ott,Elizabeth I. Buchbinder,Rizwan Haq,F. Stephen Hodi,Genevieve M. Boland,Ryan J. Sullivan,Dennie T. Frederick,Benchun Miao,Tabea Moll,Keith T. Flaherty,Meenhard Herlyn,Russell W. Jenkins,Rohit Thummalapalli,Monika S. Kowalczyk,Israel Cañadas,Bastian Schilling,Bastian Schilling,Adam N.R. Cartwright,Adrienne M. Luoma,Shruti Malu,Patrick Hwu,Chantale Bernatchez,Marie Andrée Forget,David A. Barbie,Alex K. Shalek,Itay Tirosh,Peter K. Sorger,Kai W. Wucherpfennig,Eliezer M. Van Allen,Dirk Schadendorf,Bruce E. Johnson,Asaf Rotem,Asaf Rotem,Orit Rozenblatt-Rosen,Levi A. Garraway,Charles H. Yoon,Charles H. Yoon,Benjamin Izar,Aviv Regev +54 more
TL;DR: A resistance program expressed by malignant cells that is associated with T cell exclusion and immune evasion is identified, and this study provides a high-resolution landscape of ICI-resistant cell states, identifies clinically predictive signatures, and suggests new therapeutic strategies to overcome immunotherapy resistance.
Journal ArticleDOI
Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids
Russell W. Jenkins,Amir Reza Aref,Patrick H. Lizotte,Elena Ivanova,Susanna Stinson,Chensheng W. Zhou,Michaela Bowden,Jiehui Deng,Hongye Liu,Diana Miao,Diana Miao,Meng Xiao He,Meng Xiao He,William F. Walker,Gao Zhang,Tian Tian,Chaoran Cheng,Zhi Wei,Sangeetha Palakurthi,Mark A. Bittinger,Hans Vitzthum,Jong Wook Kim,Jong Wook Kim,Ashley A. Merlino,Max M. Quinn,Chandrasekar Venkataramani,Joshua A. Kaplan,Andrew Portell,Prafulla C. Gokhale,Bart Phillips,Alicia Smart,Alicia Smart,Asaf Rotem,Robert E. Jones,Lauren Keogh,Maria Anguiano,Lance Stapleton,Zhiheng Jia,Michal Barzily-Rokni,Israel Cañadas,Tran C. Thai,Marc R. Hammond,Raven Vlahos,Eric S. Wang,Hua Zhang,Shuai Li,Glenn J. Hanna,Wei Huang,Mai P. Hoang,Adriano Piris,Jean Pierre Eliane,Anat Stemmer-Rachamimov,Lisa A. Cameron,Mei-Ju Su,Parin Shah,Benjamin Izar,Benjamin Izar,Manisha Thakuria,Manisha Thakuria,Nicole R. LeBoeuf,Nicole R. LeBoeuf,Guilherme Rabinowits,Viswanath Gunda,Sareh Parangi,James M. Cleary,Brian C. Miller,Shunsuke Kitajima,Rohit Thummalapalli,Benchun Miao,Thanh U. Barbie,Vivek Sivathanu,Joshua A. Wong,William G. Richards,Raphael Bueno,Charles H. Yoon,Juan J. Miret,Meenhard Herlyn,Levi A. Garraway,Eliezer M. Van Allen,Eliezer M. Van Allen,Gordon J. Freeman,Paul Kirschmeier,Jochen H. Lorch,Patrick A. Ott,F. Stephen Hodi,Keith T. Flaherty,Roger D. Kamm,Genevieve M. Boland,Kwok-Kin Wong,David Dornan,Cloud P. Paweletz,David A. Barbie +91 more
TL;DR: The ability to interrogate ex vivo response to PD-1 blockade using murine- and patient-derived organotypic tumor spheroids (MDOTS/PDOTS) is demonstrated, which represents a novel platform to evaluate ICB using established murine models as well as clinically relevant patient specimens.
Journal ArticleDOI
A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors
Michal Slyper,Caroline B. M. Porter,Orr Ashenberg,Julia Waldman,Eugene Drokhlyansky,Isaac Wakiro,Isaac Wakiro,Christopher Smillie,Gabriela Smith-Rosario,Jingyi Wu,Jingyi Wu,Danielle Dionne,Sébastien Vigneau,Sébastien Vigneau,Judit Jané-Valbuena,Timothy L. Tickle,Sara Napolitano,Sara Napolitano,Mei-Ju Su,Mei-Ju Su,Anand G. Patel,Asa Karlstrom,Simon Gritsch,Masashi Nomura,Avinash Waghray,Satyen H. Gohil,Satyen H. Gohil,Alexander M. Tsankov,Alexander M. Tsankov,Livnat Jerby-Arnon,Ofir Cohen,Ofir Cohen,Johanna Klughammer,Yanay Rosen,Joshua Gould,Lan Nguyen,Matan Hofree,Peter J. Tramontozzi,Bo Li,Bo Li,Catherine J. Wu,Benjamin Izar,Rizwan Haq,Rizwan Haq,F. Stephen Hodi,Charles H. Yoon,Charles H. Yoon,Aaron N. Hata,Suzanne J. Baker,Mario L. Suvà,Mario L. Suvà,Raphael Bueno,Elizabeth H. Stover,Elizabeth H. Stover,Michael R. Clay,Michael A. Dyer,Michael A. Dyer,Natalie B. Collins,Natalie B. Collins,Natalie B. Collins,Ursula A. Matulonis,Nikhil Wagle,Bruce E. Johnson,Asaf Rotem,Asaf Rotem,Orit Rozenblatt-Rosen,Aviv Regev,Aviv Regev,Aviv Regev +68 more
TL;DR: A set of ready-to-use tools for profiling fresh and frozen clinical tumor samples using scRNA-Seq and snRNA- Seq facilitates the implementation of single-cell technologies in clinical settings and the construction ofsingle-cell tumor atlases.
Journal ArticleDOI
A single-cell landscape of high-grade serous ovarian cancer.
Benjamin Izar,Itay Tirosh,Elizabeth H. Stover,Isaac Wakiro,Michael S. Cuoco,Idan Alter,Christopher Rodman,Rachel Leeson,Mei-Ju Su,Parin Shah,Marcin P. Iwanicki,Sarah R. Walker,Abhay Kanodia,Johannes C. Melms,Shaolin Mei,Jia-Ren Lin,Caroline B. M. Porter,Michal Slyper,Julia Waldman,Livnat Jerby-Arnon,Orr Ashenberg,Titus J. Brinker,Caitlin E. Mills,Meri Rogava,Sébastien Vigneau,Peter K. Sorger,Levi A. Garraway,Panagiotis A. Konstantinopoulos,Joyce F. Liu,Ursula A. Matulonis,Bruce E. Johnson,Orit Rozenblatt-Rosen,Asaf Rotem,Asaf Rotem,Aviv Regev +34 more
TL;DR: Significant inter-patient variability is found in the composition and functional programs of ascites cells, including immunomodulatory fibroblast sub-populations and dichotomous macrophage populations, which contributes to resolving the HSGOC landscape and provides a resource for the development of novel therapeutic approaches.
Posted ContentDOI
A single-cell and single-nucleus RNA-seq toolbox for fresh and frozen human tumors
Michal Slyper,Caroline B. M. Porter,Orr Ashenberg,Julia Waldman,Eugene Drokhlyansky,Isaac Wakiro,Isaac Wakiro,Christopher Smillie,Gabriela Smith-Rosario,Jingyi Wu,Jingyi Wu,Danielle Dionne,Sébastien Vigneau,Sébastien Vigneau,Judit Jané-Valbuena,Sara Napolitano,Sara Napolitano,Mei-Ju Su,Mei-Ju Su,Anand G. Patel,Asa Karlstrom,Simon Gritsch,Masashi Nomura,Avinash Waghray,Satyen H. Gohil,Satyen H. Gohil,Alexander M. Tsankov,Livnat Jerby-Arnon,Ofir Cohen,Ofir Cohen,Johanna Klughammer,Yanay Rosen,Joshua Gould,Bo Li,Bo Li,Lan Nguyen,Catherine J. Wu,Benjamin Izar,Rizwan Haq,Rizwan Haq,F. Stephen Hodi,Charles H. Yoon,Charles H. Yoon,Aaron N. Hata,Suzanne J. Baker,Mario L. Suvà,Mario L. Suvà,Raphael Bueno,Elizabeth H. Stover,Elizabeth H. Stover,Ursula A. Matulonis,Ursula A. Matulonis,Michael R. Clay,Michael A. Dyer,Michael A. Dyer,Natalie B. Collins,Natalie B. Collins,Natalie B. Collins,Nikhil Wagle,Nikhil Wagle,Asaf Rotem,Asaf Rotem,Bruce E. Johnson,Orit Rozenblatt-Rosen,Aviv Regev,Aviv Regev,Aviv Regev +66 more
TL;DR: This work provides direct guidance across a broad range of tumors, including criteria for testing and selecting methods from the toolbox for other tumors, thus paving the way for charting tumor atlases.