M
Makoto Tsuiji
Researcher at Hoshi University
Publications - 43
Citations - 3975
Makoto Tsuiji is an academic researcher from Hoshi University. The author has contributed to research in topics: Antibody & Antigen. The author has an hindex of 20, co-authored 39 publications receiving 3570 citations. Previous affiliations of Makoto Tsuiji include University of Tokyo & Tokyo Medical and Dental University.
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Journal ArticleDOI
Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning
Thomas Tiller,Eric Meffre,Sergey Yurasov,Sergey Yurasov,Makoto Tsuiji,Michel C. Nussenzweig,Michel C. Nussenzweig,Hedda Wardemann +7 more
TL;DR: The method to clone and express human monoclonal antibodies is unbiased, highly efficient, requires only small cell numbers and the recombinant antibodies allow direct conclusions on the frequency of specific human B cells in a diverse repertoire.
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Defective B cell tolerance checkpoints in systemic lupus erythematosus
Sergey Yurasov,Hedda Wardemann,Johanna Hammersen,Makoto Tsuiji,Eric Meffre,Eric Meffre,Virginia Pascual,Michel C. Nussenzweig,Michel C. Nussenzweig +8 more
TL;DR: SLE is associated with abnormal early B cell tolerance, and 25–50% of the mature naive B cells in SLE patients produce self-reactive antibodies even before they participate in immune responses as compared with 5–20% in controls.
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Autoreactivity in Human IgG+ Memory B Cells
Thomas Tiller,Makoto Tsuiji,Sergey Yurasov,Klara Velinzon,Michel C. Nussenzweig,Michel C. Nussenzweig,Hedda Wardemann +6 more
TL;DR: Surprisingly, it was found that self-reactive antibodies including anti-nuclear antibodies were frequently expressed by IgG(+) memory B cells in healthy donors.
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Human Macrophage C-Type Lectin Specific for Galactose and N-Acetylgalactosamine Promotes Filovirus Entry
Ayato Takada,Kouki Fujioka,Makoto Tsuiji,Akiko Morikawa,Nobuaki Higashi,Hideki Ebihara,Darwyn Kobasa,Heinz Feldmann,Tatsuro Irimura,Yoshihiro Kawaoka,Yoshihiro Kawaoka +10 more
TL;DR: It is demonstrated that a recently identified human macrophage galactose- and N-acetylgalactosamine-specific C-type lectin (hMGL), whose ligand specificity differs from DC-SIGN and L-SIGN, also enhances the infectivity of filoviruses.
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Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors.
Brun Mietzner,Makoto Tsuiji,Johannes F. Scheid,Klara Velinzon,Thomas Tiller,Klaus Abraham,Jose B. Gonzalez,Virginia Pascual,Dorothee Stichweh,Hedda Wardemann,Michel C. Nussenzweig +10 more
TL;DR: Heterogeneity in the frequency of memory B cells expressing SLE-associated autoantibodies suggests that this variable may be important in the outcome of therapies that ablate this compartment.