M
Malcolm Arnold
Researcher at University of Western Ontario
Publications - 21
Citations - 4632
Malcolm Arnold is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Heart failure & Hazard ratio. The author has an hindex of 18, co-authored 21 publications receiving 4317 citations. Previous affiliations of Malcolm Arnold include Brigham and Women's Hospital.
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Journal ArticleDOI
Cardiac-Resynchronization Therapy for Mild-to-Moderate Heart Failure
Anthony S.L. Tang,George A. Wells,Mario Talajic,Malcolm Arnold,Robert S. Sheldon,Stuart J. Connolly,Stefan H. Hohnloser,Graham Nichol,David H. Birnie,John L. Sapp,Raymond Yee,Jeff S. Healey,Jean L. Rouleau +12 more
TL;DR: Among patients with NYHA class II or III heart failure, a wide QRS complex, and left ventricular systolic dysfunction, the addition of CRT to an ICD reduced rates of death and hospitalization for heart failure.
Journal ArticleDOI
Relation Between Red Blood Cell Distribution Width and Cardiovascular Event Rate in People With Coronary Disease
Marcello Tonelli,Frank M. Sacks,Malcolm Arnold,Lemuel A. Moyé,Barry R. Davis,Marc A. Pfeffer +5 more
TL;DR: A graded independent relation between higher levels of RDW and the risk of death and cardiovascular events in people with prior myocardial infarction but no symptomatic heart failure at baseline is found.
Journal ArticleDOI
Warfarin and Aspirin in Patients with Heart Failure and Sinus Rhythm
Shunichi Homma,John L.P. Thompson,Patrick M. Pullicino,Bruce Levin,Ronald S. Freudenberger,John R. Teerlink,John R. Teerlink,Susan E. Ammon,Susan Graham,Ralph L. Sacco,Douglas L. Mann,Jay P. Mohr,Barry M. Massie,Barry M. Massie,Arthur J. Labovitz,Stefan D. Anker,Dirk J. Lok,Piotr Ponikowski,Conrado J. Estol,Gregory Y.H. Lip,Marco R. Di Tullio,Alexandra R. Sanford,Vilma Mejia,André P. Gabriel,Mirna Del Valle,Richard Buchsbaum,C. Moy,P. Gilbert,Laurie Gutmann,J. Marler,S. Borden,E. Peña,C. Harris,R. Khadouri,D. Gohs,Martin M. Brown,G. Berry,D. Disantis,M. Scullin,Peter K. Smith,Shun Kohsaka,W. Watson,L. Guillory,Gilberto Levy,K. Tea,Johnston Grier,L. Swydan,B. O'Hare,R. Prodhan,R. Arbing,E. Flanagan,E. Duverger,A. Peljto,W. Lo,A. Tierney,A. Henriquez,J. Keen,G. J. del Zoppo,Gregory W. Albers,M. Eliasziw,J. A. Hinchey,K. C. Johnston,April M. Lowe,Ileana L. Piña,J. A. Swain,S. Slomiak,L. Cape,H. J. Barnett,A. Bruno,J. D. Easton,Steven R. Levine,Demetrios J. Sahlas,F. Bleyer,Peter E. Carson,A. Ellis,Alan B. Miller,S. T. Palmeri,Michelle Bierig,R. Liu,C. Donato,Robert G. Hart,C. McKay,L. Wilson,E. Frey,K. Hayward,P. Stein-Beal,L. Konczarek,M. Diek,M. Rohwedder,M. Bohdanowicz-Zazula,C. F. Peerenboom-Fey,M. Vissiennon,G. Rex,M. Varga,O. Kovtun,V. Orlyk,Petr Arenberger,J. Jaros,A. Ruiz,M. Zimmermann,A. Ellenberg,A. Minagar,R. Kelley,J. McGee,P. Jinkins,S. Bezucha,V. Hart,M. Bonora,R. Sawyer,K. Ammerman,P. Ramappa,V. Berchou,E. Jones,E. Olgren,B. Hattler,C. Anderson,B. Watson,D. Wolf,J. Kosits,L. Casazza,D. Yip,J. Meschia,A. McPhail,K. Greenan,R. Rothbart,J. Love,T. Schrader,V. Garman,Marcus F. Stoddard,K. Remmel,R. Longaker,Christine Gerula,Marc Klapholz,J. Kirmani,R. Mattessich,Carlos J. Rodriguez,W. Graettinger,Andrew H. Baker,A. Valencia,P. Kosolcharoen,L. Williams,V. Sorrell,B. Coull,D. Bruck,Elizabeth O. Ofili,M. Frankel,P. Jackson,M. Nanna,S. Sparr,W. Almeida,R. Libman,B. Stephens,C. DeMers,T. Giles,L. Roffidal,D. Barratt,M. Liston,C. Lindsey,L. Giron,W. Felton,L. Joseph,M. Lee,J. Bisognano,C. Benesch,L. Caufield,E. Nishime,M. Moussavian,E. Polland,L. Fischer,K. Peterson,B. McGinnis,M. Tilem,G. Allam,J. Beebe,P. Chang,Sedat Sen,C. Schuler,L. Arcement,M. Charlet,E. Falgout,M. Malkowski,T. Dugan,J. Hobbs-Williams,A. Warner,K. Panizzon,J. Johnson,J. Dissin,D. Karia,N. Molakala,B. Dandapani,R. Vicari,E. Anthony,I. Katzan,Richard J. Hobbs,A. Richmond,Richard L. Hughes,W. Baker,M. Applegate,B. Drachman,Sami Khella,S. Donovan,A. Slim,D. Pearce Moore,B. Darrow,A. Travis,A. Mercando,R. Pellegrino,N. Jarmukli,T. Ochalek,Denise L. Janosik,J. Dizes,L. C. Pettigrew,D. Taylor,J. Hanna,S. Bailey,R. Berkowitz,S. Mathus,V. Virkud,S. Shaw,S. Nabhan,E. Wirkowski,B. George,Eric E. Smith,S. Locke,C. Landau,D. Ferguson,H. V. Anderson,L. Westbrook,M. Apelian,S. Khoury,J. Leppo,T. Bator,Udho Thadani,J. Turner,Steven Goldman,S. Daugherty,A. Adler,T. Rennie,D. Chupka,R. Katz,L. Witkin,W. Burgin,Ceri Weber,John P. Boehmer,P. Frey,M. Wilson,H. Tworek,G. Mallis,D. Mauceri,R. Schneider,W. Schneider,G. Ortiz,M. Lichtenberger,B. Hott,Donald L. Patrick,Stephanie Hope Dunlap,S. J. Kim,S. Pezzella,D. Aubin,L. Nikolaidis,J. Wong,D. Leifer,M. Rossi,G. Torre,J. Arredondo,J. Lynch,A. Metcalf,J. Gonzalez,B. Donley,Thomas P. Cappola,K. Craig,Biykem Bozkurt,Mariana Bolos,T. Noonan,C. Alteri,L. Kowalczyk,A. Cwynar,D. Drazek,Jan Biegus,Roman Szełemej,M. Jurczok,R. Serafin,A. Jurczyk,M. Ogorek,D. Kopcik,B. Metzkier-Wyrwa,A. Szczepanska,M. Dluzniewski,W. Wicha,M. Kuch,K. Kuc,R. Piotrowski,O. Lesniak,M. Krauze-Wielicka,J. Herman,S. Nowakowska,Tomasz J. Pasierski,B. Kozlowski,K. Wolkowska,A. Juszczak,J. Michalska,I. Jedlinski,P. Miekus,M. Konarzewski,P. Berkowski,N. Jacek,Zbigniew Kalarus,A. Duszanska,J. Tarchalski,P. Czaja,Zbigniew Gaciong,J. Gora,A. Kleinrok,G. Prokop-Lewicka,Haissam Haddad,R. Davies,L. Sitwell,J. Donaldson,T. To,R. Yufe,B. Donelly,T. Huynh,Robert Côté,B. St Jacques,D. Borts,G. Tullio,A. M. Sindilar,T. Winder,E. Janzen,C. Walker,G. Moe,N. Bayer,A. Konig,Malcolm Arnold,David Spence,J. Smith,R. Bessoudo,P. Bailey,A. McNulty,S. Nawaz,C. Dewar,M. Rajda,M. MacFarlane,J. Minuk,C. Schanz,Andrew M Penn,L. Atkins,A. Ducharme,H. Brown,Shelley Zieroth,A. Muñoz,J. B. ten Holter,C. Huls,P. Bruggink-Andre,A. van Bujisen-Nutters,M. Daniels,A. Coppes,M. van Zagten,N. Elzebroek,K. Hamroui,P. de Kort,J. Vuijsters,N. Holwerda,W. Hermans,R. van der Loo,Elly M.C.J. Wajon,G. Hageman,G. v Buchem-Damming,E. Ronner,A. Wissenburg-van Lieshout,H. Niekus,M. W. van Hessen,G. A. Verheul,G. Linssen,L. te Pas,J. Plomp,P. A. de Milliano,R. Breedveld,M. J. Bos,M. Houra,D. Beran,R. Lebedova,J. Carda,E. Bednarova,J. Vosmerova,G. Marcinek,T. Drasnar,O. Najmanova,M. Dunaj,E. Pechackova,M. Kuchar,P. Jansky,J. Simon,H. Dvorakova,P. Gregor,M. Maruskova,L. Svoboda,Z. Lorenc,P. Kralicek,L. Pollak,Z. Krobot,M. Krobot,Jindřich Špinar,M. Nemec,L. Spinarova,R. Kuba,F. Padour,I. Padourova,M. Padour,M. Michalova,L. Golan,M. Hajkova,J. Povolny,L. Krizova,D. Horak,P. Kucera,I. Malek,B. Krizova,J. Svoboda,R. Ferkl,L. Regos,L. Csuros,O. Lovasz,G. Kiss,S. Timar,N. Torok,A. Hajnalne,B. Palossy,A. Nagy,P. Fulop,G. Jakab,A. Ronaszeki,M. Bodi,M. Satori,I. Edes,I. Varga,Attila Kovacs,L. Berente,E. Péterfai,R. Pauer,K. Toth,E. Nagy,B. Benczur,K. Karsay,T. Vegh,R. Nagy,P. Karpati,Z. Davidovits,J. Borbola,J. Vanyi,B. Oze,A. Bujdoso,I. Kosa,L. Baliko,M. Natour,M. Morgil,E. Hartmann,H. Morgil,R. Winkler,S. Gass,S. Baumann,M. Jeserich,J. Rodl,M. Dzaiy,G. Turhan,K. Wolf,S. Genth-Zotz,T. Siebert,C. Jakobs,M. Kiorwantsi,Burkert Pieske,R. Wachter,M. Schoenauer,S. Voigt,H. Schunkert,A. Boguschewski,M. Resch,R. Wensel,V. Schumann,P. Heidrich,O. Girina,Y. Prokopovych,M. Lebedynska,I. Sorokina,O. Karpenko,N. Brodi,S. Klochkov,L. Voronkov,Y. Besaga,O. Novikova,K. Amosova,O. Yaremenko,K. Balaban,V. Kovalenko,N. Polenova,I. Sakharchuk,A. Ogorodnichuk,L. Rudenko,Y. Tutov,A. Parkhomenko,S. Kozhukhov,E. Yakimenko,S. Kolomiets,V. Yurlov,S. Tikhonova,A. Elizalde,B. Mangariello,C. Zaidman,F. Guerlloy,P. Gitelman,K. Crotto,S. Sassone,J. Aiub,F. Novoa,R. Lopez Santi,P. Romia,O. Montaña,D. Malchik,F. Sokn,P. Schygiel,R. Porcile,F. Soria Tito,J. Thierer,P. Avellana,C. Rapallo,M. Calderon,R. MacFadyen,R. Haynes,J. Partridge,M. Kokles,S. Mehešová,A. Zachar,M. Hranai,T. Varadyova,T. Göbö,J. Litvinova,P. Loviska +536 more
TL;DR: There was no significant overall difference in the primary outcome between treatment with warfarin and treatment with aspirin among patients with reduced LVEF who were in sinus rhythm, and a reduced risk of ischemic stroke withwarfarin was offset by an increased risk of major hemorrhage.
Journal ArticleDOI
Cardiovascular death and left ventricular remodeling two years after myocardial infarction: baseline predictors and impact of long-term use of captopril: information from the Survival and Ventricular Enlargement (SAVE) trial.
Martin St. John Sutton,Marc A. Pfeffer,Lemuel A. Moyé,Ted Plappert,Jean L. Rouleau,Gervasio A. Lamas,Jacques R. Rouleau,John O. Parker,Malcolm Arnold,Bruce Sussex,Eugene Braunwald +10 more
TL;DR: LV dilatation is progressive, associated with chamber distortion and deteriorating function that is unaffected by captopril beyond 1 year, and occurred in >50% of patients by 2 years.
Journal ArticleDOI
Tumor Necrosis Factor-α Mediates Cardiac Remodeling and Ventricular Dysfunction After Pressure Overload State
Mei Sun,Manyin Chen,Fayez Dawood,Urszula Zurawska,Jeff Y. Li,Thomas S. Parker,Zamaneh Kassiri,Lorrie A. Kirshenbaum,Malcolm Arnold,Rama Khokha,Peter P. Liu +10 more
TL;DR: It is suggested that TNF-&agr; contributes to adverse left ventricular remodeling during pressure overload through regulation of cardiac repair and remodeling, leading to ventricular dysfunction.