J
J. Craig Rowlands
Researcher at Dow Chemical Company
Publications - 47
Citations - 2761
J. Craig Rowlands is an academic researcher from Dow Chemical Company. The author has contributed to research in topics: Aryl hydrocarbon receptor & Gene. The author has an hindex of 24, co-authored 47 publications receiving 2446 citations. Previous affiliations of J. Craig Rowlands include University of Arkansas for Medical Sciences.
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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Patricio Godoy,Nicola J. Hewitt,Ute Albrecht,Melvin E. Andersen,Nariman Ansari,Sudin Bhattacharya,Johannes G. Bode,Jennifer Bolleyn,Christoph Borner,J Böttger,Albert Braeuning,Robert A. Budinsky,Britta Burkhardt,Neil R. Cameron,Giovanni Camussi,Chong Su Cho,Yun Jaie Choi,J. Craig Rowlands,Uta Dahmen,Georg Damm,Olaf Dirsch,María Teresa Donato,Jian Dong,Steven Dooley,Dirk Drasdo,Dirk Drasdo,Dirk Drasdo,Rowena Eakins,Karine Sá Ferreira,Valentina Fonsato,Joanna Fraczek,Rolf Gebhardt,Andrew Gibson,Matthias Glanemann,Christopher E. Goldring,María José Gómez-Lechón,Geny M. M. Groothuis,Lena Gustavsson,Christelle Guyot,David Hallifax,Seddik Hammad,Adam S. Hayward,Dieter Häussinger,Claus Hellerbrand,Philip Hewitt,Stefan Hoehme,Hermann-Georg Holzhütter,J. Brian Houston,Jens Hrach,Kiyomi Ito,Hartmut Jaeschke,Verena Keitel,Jens M. Kelm,B. Kevin Park,Claus Kordes,Gerd A. Kullak-Ublick,Edward L. LeCluyse,Peng Lu,Jennifer Luebke-Wheeler,Anna Lutz,Daniel J. Maltman,Madlen Matz-Soja,Patrick D. McMullen,Irmgard Merfort,Simon Messner,Christoph Meyer,Jessica Mwinyi,Dean J. Naisbitt,Andreas K. Nussler,Peter Olinga,Francesco Pampaloni,Jingbo Pi,Linda J. Pluta,Stefan Przyborski,Anup Ramachandran,Vera Rogiers,Cliff Rowe,Celine Schelcher,Kathrin Schmich,Michael Schwarz,Bijay Singh,Ernst H. K. Stelzer,Bruno Stieger,Regina Stöber,Yuichi Sugiyama,Ciro Tetta,Wolfgang E. Thasler,Tamara Vanhaecke,Mathieu Vinken,Thomas S. Weiss,Agata Widera,Courtney G. Woods,Jinghai James Xu,Kathy Yarborough,Jan G. Hengstler +94 more
TL;DR: This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro and how closely hepatoma, stem cell and iPS cell–derived hepatocyte-like-cells resemble real hepatocytes.
Journal ArticleDOI
Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework
Russell S. Thomas,Martin A. Philbert,Scott S. Auerbach,Barbara A. Wetmore,Michael J. DeVito,Ila Cote,J. Craig Rowlands,Maurice Whelan,Sean M. Hays,Melvin E. Andersen,M. E. Meek,Lawrence W. Reiter,Jason C. Lambert,Harvey J. Clewell,Martin L. Stephens,Q. Jay Zhao,Scott C. Wesselkamper,Lynn Flowers,Edward W. Carney,Timothy P. Pastoor,Dan D. Petersen,Carole L. Yauk,Andy Nong +22 more
TL;DR: A data-driven framework that invokes successive tiers of testing with margin of exposure (MOE) as the primary metric, providing a risk-based and animal-sparing approach to evaluate chemical safety, drawing broadly from previous experience but incorporating technological advances to increase efficiency.
Journal ArticleDOI
The Health Consequences of Early Soy Consumption
TL;DR: Results from several studies suggest that the effects of diets made with SPI+ differ significantly from those of diets to which purified soy is oflavones are added, and it seems that soy protein processed to contain lower levels of isoflavones also provides significant health benefits.
Journal ArticleDOI
Risk assessment in the 21st century: Roadmap and matrix
Michelle R. Embry,Ammie N. Bachman,David R. Bell,Alan R. Boobis,Samuel M. Cohen,Michael Dellarco,Ian C. Dewhurst,Nancy G. Doerrer,Ronald N. Hines,Angelo Moretto,Timothy P. Pastoor,Richard D. Phillips,J. Craig Rowlands,Jennifer Y. Tanir,Douglas C. Wolf,John E. Doe +15 more
TL;DR: The RISK21 integrated evaluation strategy is a problem formulation-based exposure-driven risk assessment roadmap that takes advantage of existing information to graphically represent the intersection of exposure and toxicity data on a highly visual matrix.
Journal ArticleDOI
A 21st century roadmap for human health risk assessment.
Timothy P. Pastoor,Ammie N. Bachman,David R. Bell,Samuel M. Cohen,Michael Dellarco,Ian C. Dewhurst,John E. Doe,Nancy G. Doerrer,Michelle R. Embry,Ronald N. Hines,Angelo Moretto,Richard D. Phillips,J. Craig Rowlands,Jennifer Y. Tanir,Douglas C. Wolf,Alan R. Boobis +15 more
TL;DR: This paper provides a brief overview of the tiered RISK21 framework called the roadmap and risk visualization matrix, and articulates the core principles derived by RISk21 participants that guided its development.