Showing papers in "Leukemia Research in 1999"

TL;DR: The establishment and characterization of two cell lines, MEC1 and MEC2, that grew spontaneously on two subsequent occasions from the peripheral blood of a patient with B-chronic lymphocytic leukemia in prolymphocytoid transformation are reported.

TL;DR: Data suggests that each of these two diseases constitutes a distinct entity, which is also different from mature NK cell malignancies.

TL;DR: Morphologic and DNA fragmentation analysis proved that BC-4 induced cell apoptosis and the dual apoptotic and differentiation effects ofBC-4 suggest that it may be a powerful agent in the treatment of leukemia.

TL;DR: The results supported the hypothesis that the WT1 gene performs an oncogenic rather than a tumor suppressor gene function in hematopoietic progenitor cells, although theWT1 gene potentially performs both functions.

TL;DR: The p53 mutations are infrequent at diagnosis but tend to be associated with poor clinical outcome; RAS and p21 mutations may not be involved in the pathogenesis of T-ALL; not only frequent alterations of p16 and p15 genes but also methylation of p 16 gene are involved in initiating the leukemogenesis ofT-ALLs.

TL;DR: Findings suggest a lack of hematopoietic supportive function in some cases of MDS RA and also indicate that there is heterogeneity of stromal function among M DS RA patients.

TL;DR: The skin involvement of the myelodysplastic syndrome can take the form of either a neoplastic infiltration or various non specific lesions, which may herald its progression to acute leukemia.

TL;DR: In this randomized trial, the addition of mitoxantrone to high-dose cytarabine was associated with a trend toward a higher CR rate and there was less evidence for an advantage in disease-free or overall survival, although any such conclusion is limited by the size of the study.

TL;DR: The availability of a panel of Ph + cell lines as highly informative leukemia models offers the unique opportunity to analyze the pathobiology of these malignancies and the role of the Ph chromosome in leukemogenesis.

TL;DR: In this paper, the authors show that the ratio of Bax to Bcl-2 protein can determine whether cells will die via apoptosis or be protected from it. And they conclude that expression of bax is necessary for apoptosis-induction in this model.

TL;DR: There were statistically significant trends in risk with increasing duration and number of hair dye use and environmental factors to myelodysplastic syndromes, and occupational exposure to organic solvents was marginally associated with the risk of MDS.

TL;DR: The results show that sclareol kills cell lines, through the process of apoptosis, the first report, that a labdane-type diterpene kills tumor cells via a phase specific mechanism which induces apoptosis.

TL;DR: The results suggest that the GSTT1 null genotype may play a role in an increased risk of myelodysplasia unrelated to other mechanisms of myELodys plasia, such as chromosomal alterations or mutation of TP53 or NRAS.

TL;DR: In this paper, the authors analyzed the total transfusion support required, and its complications and cost, following the diagnosis of myelodysplastic syndromes (MDS) in 50 patients followed at the Minneapolis VA Medical Center.

TL;DR: An algorithm based on BM blast cell and pathological sideroblast counts that has been verified on 613 patients from different Spanish centers may be of help to improve reproducibility in Myelodysplastic syndrome (MDS) diagnosis.

TL;DR: This is the first demonstration that paclitaxel and ceramide interact in a supra-additive manner to decrease leukemic T-cell growth, suggesting a possible application of paclitrixel and Ceramide in combination therapy.

TL;DR: The results suggest that the most effective strategies of immunotherapy against leukemia may also exceed the threshold of anergic cells, leading to a loss of self tolerance to normal self-antigens and the induction of an CD8+ anti-self effector response.

TL;DR: Hospital mortality and morbidity in patients with chronic lymphocytic leukemia undergoing open heart surgery are high and infection is the leading cause of hospital death, as well as the most common complication.

TL;DR: Results indicate that reactivation of telomerase activity is a key event in development and progression of ATL, and telomersase could be a useful marker for predicting the course of disease.

TL;DR: A new methodology for the plasma cell evaluation in MM is proposed, that is based on the morphological criteria and that has the advantage of identifying an intermediate (30%) subgroup of patients with a prognostic significance.

TL;DR: The smallest commonly deleted regions are identified to be at 7q31.1 (D7S486) and 7q33-34 (D 7S498, D7S505) suggesting that alterations of a TSG in each region have an important role in de novo AML.

TL;DR: Despite the poor prognosis reported in AML patients with +21 as the sole abnormality, the patient in this series who was able to complete intensive treatment was cured of disease and the role of +21 in leukemogenesis is reviewed.

TL;DR: The efficacy of IDA in MDR MM cell lines is superior to that of DOX or DNR, and that IDA may become an important drug in the treatment of MM, especially in refractory disease.

TL;DR: An analytical overview on what has been achieved on apoptosis in MDS and what remains to be done is provided, to address more questions rather than to provide answers and to discuss directions for future studies.

TL;DR: In conclusion, it appears necessary to consider the particular differentiation stage of each individual cell line when using T-cell leukemia lines as models for malignant or normal T cells.

TL;DR: Findings suggest that TGF-beta1 is involved in the antiproliferative effect of EB1089 on HL-60 cells.

TL;DR: A significant difference was observed between the proportion of cells with p53 deletion in HCL-V cases ( mean 31%) and HCL cases (mean 12%) P value < 0.01, which correlates with the well known tendency for transformation and poor response to therapy in H CL-V.

TL;DR: A novel aminosteroid, 2beta-(4'-methyl-1'piperazinyl)-3alpha,17beta-dihydroxyl+ ++-5alpha-androstane (HY), was found to inhibit proliferation of HL-60 leukemia cells and induce these cells to differentiate toward macrophage-like cells from the following evidence.

TL;DR: The results suggest that, at least in some patients, HPC--besides showing an impaired proliferative capacity--lose their ability to adhere to the stromal cell layers developed in culture.

TL;DR: The expression of GAS6 reveals a constitutive transcriptional activation in 8/46 cases of proliferating cell lines, and evidence for an autocrine regulation of growth in permanent hematopoietic cell lines is demonstrated.