M
Manfred Brigl
Researcher at Brigham and Women's Hospital
Publications - 31
Citations - 5836
Manfred Brigl is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Natural killer T cell & CD1D. The author has an hindex of 24, co-authored 28 publications receiving 4985 citations. Previous affiliations of Manfred Brigl include Harvard University & Ludwig Maximilian University of Munich.
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Journal ArticleDOI
CD1: antigen presentation and T cell function.
Manfred Brigl,Michael B. Brenner +1 more
TL;DR: The function of CD1-restricted T cells in antimicrobial responses, antitumor immunity, and in regulating the balance between tolerance and autoimmunity is described.
Journal ArticleDOI
Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host.
Bina Choi,Manish Chandra Choudhary,James Regan,Jeffrey A. Sparks,Robert F. Padera,Xueting Qiu,Isaac H. Solomon,Hsiao Hsuan Kuo,Julie Boucau,Kathryn Bowman,U. Das Adhikari,Marisa L. Winkler,Alisa A. Mueller,Tiffany Y.T. Hsu,Michaël Desjardins,Lindsey R. Baden,Brian Chan,Bruce D. Walker,Mathias Lichterfeld,Manfred Brigl,Douglas S. Kwon,Sanjat Kanjilal,Eugene T Richardson,A. Helena Jonsson,Galit Alter,Amy K. Barczak,William P. Hanage,Xu G. Yu,Gaurav D. Gaiha,Michael S. Seaman,Manuela Cernadas,Jonathan Z. Li +31 more
TL;DR: An immunocompromised patient who had persistent infection with SARS-CoV-2 over a period of months, despite several courses of treatment, is described.
Journal ArticleDOI
Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions
TL;DR: Recent advances in understanding of the innate-like mechanisms underlying iNKT cell activation are discussed and how lipid antigens, the inflammatory milieu and interactions with other immune cell subsets regulate the functions of iN KT cells in health and disease are described.
Journal ArticleDOI
Mechanism of CD1d-restricted natural killer T cell activation during microbial infection
TL;DR: This data support a model in which NKT cells use a unique activation mechanism not requiring their recognition of microbial antigens, and propose this mechanism of activation as a major pathway responsible for the rapid activation of N KT cells in different microbial infections.
Journal ArticleDOI
Apolipoprotein-mediated pathways of lipid antigen presentation
Peter van den Elzen,Salil Garg,Luis E. De León,Manfred Brigl,Elizabeth A. Leadbetter,Jenny E. Gumperz,Christopher C. Dascher,Tan-Yun Cheng,Frank M. Sacks,Petr A. Illarionov,Gurdyal S. Besra,Sally C. Kent,D. Branch Moody,Michael B. Brenner +13 more
TL;DR: The immune system has co-opted a component of lipid metabolism to develop immunological responses to lipid antigens, and this work defines the pathways mediating markedly efficient exogenous lipid antigen delivery by apolipoproteins to achieve T-cell activation.