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Manfred Heller
Researcher at University of Bern
Publications - 109
Citations - 3960
Manfred Heller is an academic researcher from University of Bern. The author has contributed to research in topics: Proteome & Biology. The author has an hindex of 30, co-authored 97 publications receiving 3488 citations. Previous affiliations of Manfred Heller include Institute for Systems Biology & University Hospital of Basel.
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Journal ArticleDOI
Proteomics Analysis of Cellular Response to Oxidative Stress EVIDENCE FOR IN VIVO OVEROXIDATION OF PEROXIREDOXINS AT THEIR ACTIVE SITE
Thierry Rabilloud,Manfred Heller,Françoise Gasnier,Sylvie Luche,Catherine Rey,Ruedi Aebersold,Mohamed Benahmed,Pierre Louisot,Joël Lunardi +8 more
TL;DR: Proteomics analysis reported here shows that a major cellular response to oxidative stress is the modification of several peroxiredoxins, being both important peroxide-destroying enzymes and peroxide targets.
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Polydnaviruses of braconid wasps derive from an ancestral nudivirus.
Annie Bézier,Marc Annaheim,Juline Herbinière,Christoph Wetterwald,Gabor Gyapay,Sylvie Bernard-Samain,Patrick Wincker,Isabel Roditi,Manfred Heller,Maya Belghazi,Rita Pfister-Wilhem,Georges Periquet,Catherine Dupuy,Elisabeth Huguet,Anne-Nathalie Volkoff,Beatrice Lanzrein,Jean-Michel Drezen +16 more
TL;DR: It is found that the nudiviral genes themselves are no longer packaged but are actively transcribed and produce particles used to deliver genes essential for successful parasitism in lepidopteran hosts.
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Proteomics meets cell biology: The establishment of subcellular proteomes
TL;DR: This review highlights recent developments in this area of proteomics, namely the establishment of two‐dimensional electrophoresis (2‐DE) reference maps of subcellular compartments and organelles as well as the characterization of macromolecular structures and multiprotein complexes using a proteomics approach.
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Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labeling
Philip V'kovski,Markus Gerber,Jenna N. Kelly,Jenna N. Kelly,Stephanie Pfaender,Nadine Ebert,Sophie Braga Lagache,Cedric Simillion,Jasmine Portmann,Hanspeter Stalder,Véronique Gaschen,Rémy Bruggmann,Michael Hubert Stoffel,Manfred Heller,Ronald Dijkman,Volker Thiel +15 more
TL;DR: A spatial link between viral RNA synthesis and diverse host factors of unprecedented breadth is established and may serve as a paradigm for other positive-strand RNA viruses and provide a starting point for a comprehensive analysis of critical virus-host interactions that represent targets for therapeutic intervention.
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Trypsin catalyzed 16O-to-18O exchange for comparative proteomics: tandem mass spectrometry comparison using MALDI-TOF, ESI-QTOF, and ESI-ion trap mass spectrometers.
TL;DR: In this paper, the authors proposed a method for quantifying differentially labeled proteins on an ion trap mass spectrometer with a mass resolution of about 2000 in automated data dependent LC-MS/MS acquisition mode.