M
Marcel Spaargaren
Researcher at University of Amsterdam
Publications - 115
Citations - 10502
Marcel Spaargaren is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Wnt signaling pathway & Hepatocyte growth factor. The author has an hindex of 46, co-authored 105 publications receiving 9563 citations. Previous affiliations of Marcel Spaargaren include Tohoku University & Onyx Pharmaceuticals.
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Journal ArticleDOI
Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936.
J. J. M. Van Dongen,Anthonie Willem Langerak,Monika Brüggemann,Paul Evans,Michael Hummel,F. L. Lavender,Eric Delabesse,Frederic Davi,Ed Schuuring,Ramón García-Sanz,J.H.J.M. van Krieken,J Droese,David Gonzalez,Christian Bastard,Helen E. White,Marcel Spaargaren,Marcos González,A Parreira,John L. Smith,Gareth J. Morgan,Michael Kneba,Elisabeth Macintyre +21 more
TL;DR: The BIOMED-2 multiplex tubes can now be used for diagnostic clonality studies as well as for the identification of PCR targets suitable for the detection of minimal residual disease.
Journal ArticleDOI
The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia
Martin F. M. de Rooij,Annemieke Kuil,Christian R. Geest,Eric Eldering,Betty Y. Chang,Joseph J. Buggy,Steven T. Pals,Marcel Spaargaren +7 more
TL;DR: The data indicate that inhibition of BTK by PCI-32765 overcomes BCR- and chemokine-controlled integrin-mediated retention and homing of malignant B cells in their growth- and survival-supporting lymph node and bone marrow microenvironment, which results in clinically evident CLL regression.
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EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations
Anthonie Willem Langerak,Patricia J. T. A. Groenen,Monika Brüggemann,Kheira Beldjord,Cristiana Bellan,Lisa Bonello,Elke Boone,G. I. Carter,Mark Catherwood,Frederic Davi,M. H. Delfau-Larue,Timothy C. Diss,Paul Evans,Paula Gameiro,R. García Sanz,David Gonzalez,D. Grand,A. Håkansson,Michael Hummel,Hongxiang Liu,L. Lombardia,Elizabeth Macintyre,BJ Milner,Santiago Montes-Moreno,Ed Schuuring,Marcel Spaargaren,Elizabeth Hodges,J. J. M. Van Dongen +27 more
TL;DR: Collectively, the EuroClonality (BIOMED-2) guidelines and consensus reporting system should help to improve the general performance level of clonality assessment and interpretation, which will directly impact on routine clinical management in patients with suspected lymphoproliferations.
Journal ArticleDOI
Differential Interaction of the Ras Family GTP-binding Proteins H-Ras, Rap1A, and R-Ras with the Putative Effector Molecules Raf Kinase and Ral-Guanine Nucleotide Exchange Factor*
TL;DR: In this article, the interaction between Ral-guanine nucleotide exchange factor (RGF) and Rap1A was studied in solution and it was shown that RGF-RBD is an effector molecule of Rap1a rather than of H-Ras.
Journal ArticleDOI
Illegitimate WNT signaling promotes proliferation of multiple myeloma cells
Patrick W. B. Derksen,Esther P. M. Tjin,Helen P. Meijer,Melanie D. Klok,Harold D. Mac Gillavry,Marinus H. J. van Oers,Henk M. Lokhorst,Andries C. Bloem,Hans Clevers,Roel Nusse,Ronald van der Neut,Marcel Spaargaren,Steven T. Pals +12 more
TL;DR: It is suggested that multiple myeloma cells are dependent on an active WNT signal, which may have important implications for the management of this incurable form of cancer.