M
Maria Bellio
Researcher at Federal University of Rio de Janeiro
Publications - 61
Citations - 2312
Maria Bellio is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 24, co-authored 61 publications receiving 1935 citations. Previous affiliations of Maria Bellio include Pontifical Catholic University of Rio de Janeiro & Rio de Janeiro State University.
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Journal ArticleDOI
Inflammasome-derived IL-1β production induces nitric oxide-mediated resistance to Leishmania.
Djalma S. Lima-Junior,Diego L. Costa,Vanessa Carregaro,Larissa D. Cunha,Alexandre L. N. Silva,Tiago W. P. Mineo,Tiago W. P. Mineo,Fredy R. S. Gutierrez,Fredy R. S. Gutierrez,Maria Bellio,Karina R. Bortoluci,Richard A. Flavell,Marcelo T. Bozza,João Santana da Silva,Dario S. Zamboni +14 more
TL;DR: It is shown that the Nlrp3 inflammasome is activated in response to Leishmania infection and is important for the restriction of parasite replication both in macrophages and in vivo as demonstrated through the infection of inflammaome-deficient mice with Leishmaniasis.
Journal ArticleDOI
Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika Virus Infection in Different Cell Models
Rodrigo Delvecchio,Luisa M. Higa,Paula Pezzuto,Ana Luiza Chaves Valadão,Patricia P. Garcez,Fábio Luiz Monteiro,Erick Correia Loiola,André Alves Dias,Fabio J Moreira da Silva,Matthew T. Aliota,Elizabeth A. Caine,Jorge E. Osorio,Maria Bellio,David H. O’Connor,Stevens K. Rehen,Renato S. Aguiar,Andrea Savarino,Loraine Campanati,Amilcar Tanuri +18 more
TL;DR: It is demonstrated that chloroquine reduces the number of ZikV-infected cells in vitro, and inhibits virus production and cell death promoted by ZIKV infection without cytotoxic effects.
Journal ArticleDOI
Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi.
Ana Carolina Oliveira,Jaqueline R. Peixoto,Luciana Barros de Arruda,Marco Antônio Campos,Ricardo T. Gazzinelli,Douglas T. Golenbock,Shizuo Akira,José O. Previato,Lucia Mendonça-Previato,Alberto Nobrega,Maria Bellio +10 more
TL;DR: The results demonstrate that natural resistance to T. cruzi is TLR4 dependent, most likely due toTLR4 recognition of their GIPLs, and find that TLR 4-mutant mice were hypersusceptible to the infection, as evidenced by a higher parasitemia and earlier mortality.
Journal ArticleDOI
Antifungal Pisum sativum defensin 1 interacts with Neurospora crassa cyclin F related to the cell cycle
Denise S. Lobo,Iuri B Pereira,Lucianne Fragel-Madeira,Luciano Neves de Medeiros,Luiz M Cabral,Jane Faria,Maria Bellio,Reinaldo Calixto de Campos,Rafael Linden,Eleonora Kurtenbach +9 more
TL;DR: The results demonstrated that the plant defensin Psd1 regulates interkinetic nuclear migration in retinal neuroblasts and directed cell cycle impairment and caused conidia to undergo endoreduplication in neonatal rats.
Journal ArticleDOI
Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice.
Cláudia P. Figueiredo,Fernanda G. Q. Barros-Aragão,Rômulo L. S. Neris,Paula S. Frost,Carolina Pontes Soares,Isis N. O. Souza,Julianna D. Zeidler,Daniele Coradini Zamberlan,Virginia L. de Sousa,Amanda Santos de Souza,André Luis de Alcantara Guimarães,Maria Bellio,Jorge Marcondes de Souza,Soniza Vieira Alves-Leon,Gilda Neves,Heitor A. Paula-Neto,Newton G. Castro,Fernanda G. De Felice,Fernanda G. De Felice,Iranaia Assunção-Miranda,Julia R. Clarke,Andrea T. Da Poian,Sergio T. Ferreira +22 more
TL;DR: The functional consequences of Zika virus (ZIKV) infection in the adult brain are investigated, and it is shown that ZIKV causes synapse damage and altered brain function that impacts cognition via activation of innate and inflammatory factors.