M
Marcia S. Brose
Researcher at University of Pennsylvania
Publications - 12
Citations - 1420
Marcia S. Brose is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Thyroid cancer & Lenvatinib. The author has an hindex of 6, co-authored 12 publications receiving 566 citations. Previous affiliations of Marcia S. Brose include Hospital of the University of Pennsylvania.
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Journal ArticleDOI
Efficacy of Selpercatinib in RET-Altered Thyroid Cancers
Lori J. Wirth,Eric J. Sherman,Bruce G. Robinson,Benjamin Solomon,Hyunseok Kang,Jochen H. Lorch,Francis P. Worden,Marcia S. Brose,Jyoti D. Patel,Sophie Leboulleux,Yann Godbert,Fabrice Barlesi,John C. Morris,Taofeek K. Owonikoko,Daniel Shao-Weng Tan,Oliver Gautschi,Jared Weiss,Christelle De La Fouchardiere,Mark E. Burkard,Janessa Laskin,Matthew H. Taylor,Matthias Kroiss,Jacques Medioni,Jonathan W. Goldman,Todd M. Bauer,Benjamin Levy,Viola W. Zhu,Nehal Lakhani,Victor Moreno,Kevin Ebata,Michele Nguyen,Dana Heirich,Edward Y. Zhu,Xin Huang,L. Yang,Jennifer Kherani,S. Michael Rothenberg,Alexander Drilon,Vivek Subbiah,Manisha H. Shah,Maria E. Cabanillas +40 more
TL;DR: In this phase 1-2 trial, selpercatinib showed durable efficacy with mainly low-grade toxic effects in patients with medullary thyroid cancer with and without previous vandetanib or cabozantinib treatment.
Journal ArticleDOI
Lenvatinib plus pembrolizumab in patients with advanced endometrial cancer: an interim analysis of a multicentre, open-label, single-arm, phase 2 trial.
Vicky Makker,Drew W. Rasco,Nicholas J. Vogelzang,Marcia S. Brose,Allen Lee Cohn,James W. Mier,Christopher Di Simone,David M. Hyman,Daniel E. Stepan,Corina E. Dutcus,Emmett V. Schmidt,Matthew Guo,Pallavi Sachdev,Robert Shumaker,Carol Aghajanian,Matthew H. Taylor +15 more
TL;DR: Lenvatinib plus pembrolizumab showed anti-tumour activity in patients with advanced recurrent endometrial cancer with a safety profile that was similar to those previously reported for lenvatinIB and pembrology monotherapies, apart from an increased frequency of hypothyroidism.
Journal ArticleDOI
Lenvatinib Plus Pembrolizumab in Patients With Advanced Endometrial Cancer
Vicky Makker,Matthew H. Taylor,Carol Aghajanian,Ana Oaknin,James W. Mier,Allen Lee Cohn,Margarita Romeo,Raquel Bratos,Marcia S. Brose,Christopher DiSimone,Mark Messing,Daniel E. Stepan,Corina E. Dutcus,Jane Wu,Emmett V. Schmidt,Robert Orlowski,Pallavi Sachdev,Robert Shumaker,Antonio Casado Herraez +18 more
TL;DR: Lenvatinib plus pembrolizumab showed promising antitumor activity in patients with advanced endometrial carcinoma who have experienced disease progression after prior systemic therapy, regardless of tumor MSI status.
Journal ArticleDOI
Pralsetinib for patients with advanced or metastatic RET-altered thyroid cancer (ARROW): a multi-cohort, open-label, registrational, phase 1/2 study
Vivek Subbiah,Mimi I. Hu,Lori J. Wirth,Martin Schuler,Aaron S. Mansfield,Giuseppe Curigliano,Marcia S. Brose,Viola W. Zhu,Sophie Leboulleux,Daniel W. Bowles,Christina S. Baik,Douglas Adkins,Bhumsuk Keam,Ignacio Matos,Elena Garralda,Justin F. Gainor,Gilberto Lopes,Chia-Chi Lin,Yann Godbert,Debashis Sarker,Stephen G. Miller,Corinne Clifford,Hui Zhang,Christopher D. Turner,Matthew H. Taylor +24 more
TL;DR: The ARROW trial as discussed by the authors evaluated the safety and antitumour activity of pralsetinib, a highly potent, selective RET inhibitor, in patients with RET-altered thyroid cancers.
Journal ArticleDOI
PL02.08 Registrational Results of LIBRETTO-001: A Phase 1/2 Trial of LOXO-292 in Patients with RET Fusion-Positive Lung Cancers
A. Drilon,Geoffrey R. Oxnard,Lori J. Wirth,Benjamin Besse,Oliver Gautschi,S.W.D. Tan,Herbert H. Loong,Todd M. Bauer,Yu Jung Kim,A. Horiike,Kwang Bo Park,Manisha H. Shah,Caroline E. McCoach,Lyudmila Bazhenova,Takashi Seto,Marcia S. Brose,Nathan A. Pennell,Jared Weiss,I. Matos,Nir Peled,Byoung Chul Cho,Yuichiro Ohe,Karen L. Reckamp,Valentina Boni,Miyako Satouchi,Gerald Steven Falchook,Wallace Akerley,H. Daga,T. Sakamoto,Jyoti D. Patel,Nehal Lakhani,Fabrice Barlesi,Mark E. Burkard,Viola W. Zhu,V. Moreno Garcia,J. Medioni,Marc R. Matrana,Christian D. Rolfo,Dae Ho Lee,Hovav Nechushtan,Melissa Lynne Johnson,Vamsidhar Velcheti,Makoto Nishio,R. Toyozawa,Kadoaki Ohashi,L. Song,J. Han,A. Spira,F. de Braud,K. Staal Rohrberg,Shinji Takeuchi,J. Sakakibara,Saiama N. Waqar,H. Kenmotsu,F. Wilson,Binoj Nair,Elizabeth Olek,Jennifer Kherani,K. Ebata,Edward Y. Zhu,Michele Nguyen,Ling Yang,X. Huang,S. Cruickshank,S. Rothenberg,Ben Solomon,K. Goto,Vivek Subbiah +67 more