Ana Carolina Oliveira

TL;DR: Medicinal foods or metabolites might represent an effective and natural approach for countering the numerous immunological defects that contribute to T cell–dependent autoimmune diseases.

TL;DR: The results demonstrate that natural resistance to T. cruzi is TLR4 dependent, most likely due toTLR4 recognition of their GIPLs, and find that TLR 4-mutant mice were hypersusceptible to the infection, as evidenced by a higher parasitemia and earlier mortality.

TL;DR: The role of TLR-activated pathways in the modulation of both innate and acquired immune responses to T. cruzi infection is focused on and the state of the art of vaccine research and development against the causative agent of Chagas disease is discussed.

TL;DR: Results indicate that TLR4, as well as previously shown for TLR2, TLR9 and MyD88, contributes to the innate immune response and, consequently, resistance in the acute phase of infection, although each of these pathways is not individually essential for the generation of class I-restricted responses against T. cruzi.

TL;DR: Results indicate that miltefosine causes apoptosis-like death in L. amazonensis promastigote cells using a similar process that is observed in Leishmania donovani.