M
Marco Craveiro
Researcher at University of Montpellier
Publications - 14
Citations - 930
Marco Craveiro is an academic researcher from University of Montpellier. The author has contributed to research in topics: CD8 & Immune system. The author has an hindex of 8, co-authored 10 publications receiving 716 citations. Previous affiliations of Marco Craveiro include University of Coimbra & Centre national de la recherche scientifique.
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Journal ArticleDOI
Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
Dorota Klysz,Xuguang Tai,Philippe Robert,Marco Craveiro,Gaspard Cretenet,Leal Oburoglu,Cédric Mongellaz,Stefan Floess,Vanessa Fritz,Maria I. Matias,Carmen S M Yong,Carmen S M Yong,Natalie Surh,Julien C. Marie,Julien C. Marie,Jochen Huehn,Valérie S. Zimmermann,Sandrina Kinet,Valerie Dardalhon,Naomi Taylor +19 more
TL;DR: It is shown that exogenous nutrient availability regulated the differentiation of naïve CD4+ T cells into distinct subsets, and α-ketoglutarate (αKG), the glutamine-derived metabolite that enters into the mitochondrial citric acid cycle, acted as a metabolic regulator of CD4- T cell differentiation.
Journal ArticleDOI
Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification
Leal Oburoglu,Saverio Tardito,Vanessa Fritz,Stéphanie C. De Barros,Peggy Merida,Marco Craveiro,João I. Mamede,Gaspard Cretenet,Cédric Mongellaz,Xiuli An,Xiuli An,Dorota Klysz,Jawida Touhami,Myriam Boyer-Clavel,Jean-Luc Battini,Valérie Dardalhon,Valérie S. Zimmermann,Narla Mohandas,Eyal Gottlieb,Marc Sitbon,Sandrina Kinet,Naomi Taylor +21 more
TL;DR: It is shown that the commitment of human and murine HSCs to the erythroid lineage is dependent upon glutamine metabolism, which regulates HSC lineage commitment under conditions of metabolic stress.
Journal ArticleDOI
Glut1-mediated glucose transport regulates HIV infection
Severine Loisel-Meyer,Louise Swainson,Marco Craveiro,Leal Oburoglu,Cédric Mongellaz,Caroline Costa,Marion Martinez,François-Loïc Cosset,Jean-Luc Battini,Leonard A. Herzenberg,Leonore A. Herzenberg,Kondala R. Atkuri,Marc Sitbon,Sandrina Kinet,Els Verhoeyen,Naomi Taylor +15 more
TL;DR: It is shown that at physiological oxygen levels (2–5% O2 tension in lymphoid organs), IL-7 stimulation generates an environment permissive to HIV-1 infection, despite a significantly attenuated level of cell cycle entry.
Journal ArticleDOI
Cell surface Glut1 levels distinguish human CD4 and CD8 T lymphocyte subsets with distinct effector functions.
Gaspard Cretenet,Isabelle Clerc,Maria I. Matias,Séverine Loisel,Marco Craveiro,Leal Oburoglu,Sandrina Kinet,Cédric Mongellaz,Valerie Dardalhon,Naomi Taylor +9 more
TL;DR: Glut1 surface levels identify human T lymphocytes with distinct effector functions in both hypoxic and atmospheric oxygen tensions, and these levels exhibited significantly enhanced ability to produce IFN-γ.
Journal ArticleDOI
Isolated receptor binding domains of HTLV-1 and HTLV-2 envelopes bind Glut-1 on activated CD4+ and CD8+ T cells
Sandrina Kinet,Sandrina Kinet,Louise Swainson,Louise Swainson,Madakasira Lavanya,Madakasira Lavanya,Cédric Mongellaz,Cédric Mongellaz,Amélie Montel-Hagen,Amélie Montel-Hagen,Marco Craveiro,Marco Craveiro,Nicolas Manel,Jean-Luc Battini,Jean-Luc Battini,Marc Sitbon,Naomi Taylor,Naomi Taylor +17 more
TL;DR: Transfection of Glut-1 directly correlates with the capacities ofHTLV-1 and HTLV-2 envelope-derived ligands to bind cells, and is induced by TCR engagement, resulting in massive increases in glucose uptake and binding of HTLV1 and -2 envelopes to both CD4 and CD8 T lymphocytes.