V
Valérie S. Zimmermann
Researcher at University of Montpellier
Publications - 43
Citations - 3390
Valérie S. Zimmermann is an academic researcher from University of Montpellier. The author has contributed to research in topics: Antigen & Immune system. The author has an hindex of 16, co-authored 37 publications receiving 2907 citations. Previous affiliations of Valérie S. Zimmermann include Mario Negri Institute for Pharmacological Research & French Institute of Health and Medical Research.
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Journal ArticleDOI
Maturation Stages of Mouse Dendritic Cells in Growth Factor–dependent Long-Term Cultures
Claudia Winzler,Patrizia Rovere,Maria Rescigno,Francesca Granucci,Giuseppe Penna,Luciano Adorini,Valérie S. Zimmermann,Jean Davoust,Paola Ricciardi-Castagnoli +8 more
TL;DR: The signals controlling the checkpoints of dendritic cells (DC) maturation and the correlation between phenotypical and functional maturational stages were investigated in a defined model system of growth factor–dependent immature mouse DC.
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Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites
François Gerbe,François Gerbe,François Gerbe,Emmanuelle Sidot,Emmanuelle Sidot,Emmanuelle Sidot,Danielle J. Smyth,Makoto Ohmoto,Ichiro Matsumoto,Valerie Dardalhon,Valerie Dardalhon,Pierre Cesses,Pierre Cesses,Pierre Cesses,Laure Garnier,Laure Garnier,Laure Garnier,Marie Pouzolles,Marie Pouzolles,Bénédicte Brulin,Bénédicte Brulin,Bénédicte Brulin,Marco Bruschi,Marco Bruschi,Marco Bruschi,Yvonne Harcus,Valérie S. Zimmermann,Valérie S. Zimmermann,Naomi Taylor,Naomi Taylor,Rick M. Maizels,Philippe Jay,Philippe Jay,Philippe Jay +33 more
TL;DR: It is shown that tuft cells, a rare epithelial cell type in the steady-state intestinal epithelium, are responsible for initiating type 2 responses to parasites by a cytokine-mediated cellular relay and a cellular relay required for initiating mucosal type 2 immunity to helminth infection.
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Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
Dorota Klysz,Xuguang Tai,Philippe Robert,Marco Craveiro,Gaspard Cretenet,Leal Oburoglu,Cédric Mongellaz,Stefan Floess,Vanessa Fritz,Maria I. Matias,Carmen S M Yong,Carmen S M Yong,Natalie Surh,Julien C. Marie,Julien C. Marie,Jochen Huehn,Valérie S. Zimmermann,Sandrina Kinet,Valerie Dardalhon,Naomi Taylor +19 more
TL;DR: It is shown that exogenous nutrient availability regulated the differentiation of naïve CD4+ T cells into distinct subsets, and α-ketoglutarate (αKG), the glutamine-derived metabolite that enters into the mitochondrial citric acid cycle, acted as a metabolic regulator of CD4- T cell differentiation.
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The long pentraxin PTX3 binds to apoptotic cells and regulates their clearance by antigen-presenting dendritic cells.
Patrizia Rovere,Patrizia Rovere,Patrizia Rovere,Giuseppe Peri,Giuseppe Peri,Giuseppe Peri,Fausto Fazzini,Fausto Fazzini,Fausto Fazzini,Barbara Bottazzi,Barbara Bottazzi,Barbara Bottazzi,Andrea Doni,Andrea Doni,Andrea Doni,Attilio Bondanza,Attilio Bondanza,Attilio Bondanza,Valérie S. Zimmermann,Valérie S. Zimmermann,Valérie S. Zimmermann,Cecilia Garlanda,Cecilia Garlanda,Cecilia Garlanda,Umberto Fascio,Umberto Fascio,Umberto Fascio,Maria Grazia Sabbadini,Maria Grazia Sabbadini,Maria Grazia Sabbadini,Claudio Rugarli,Claudio Rugarli,Claudio Rugarli,A Mantovani,A Mantovani,A Mantovani,Angelo A. Manfredi,Angelo A. Manfredi,Angelo A. Manfredi +38 more
TL;DR: The results suggest that PTX3 sequesters cell remnants from antigen-presenting cells, possibly contributing to preventing the onset of autoimmune reactions in inflamed tissues.
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Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells
Chamutal Bornstein,Shir Nevo,Amir Giladi,Noam Kadouri,Marie Pouzolles,François Gerbe,Eyal David,Alice Machado,Anna Chuprin,Beáta Tóth,Ori Goldberg,Shalev Itzkovitz,Naomi Taylor,Philippe Jay,Valérie S. Zimmermann,Jakub Abramson,Ido Amit +16 more
TL;DR: This study provides a comprehensive characterization of the thymic stroma and identifies a new tuft-like TEC population, which is critical for shaping the immune niche in the Thymus, and highlights four major medullary TEC populations with distinct molecular functions, epigenetic landscapes and lineage regulators.