M
Marcos Ortega
Researcher at University of Zurich
Publications - 3
Citations - 593
Marcos Ortega is an academic researcher from University of Zurich. The author has contributed to research in topics: Epilepsy & Genome-wide association study. The author has an hindex of 3, co-authored 3 publications receiving 567 citations.
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Journal ArticleDOI
Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes.
Erin L. Heinzen,Rodney A. Radtke,Thomas J. Urban,Gianpiero L. Cavalleri,Chantal Depondt,Anna C. Need,Nicole M. Walley,Paola Nicoletti,Dongliang Ge,Claudia B. Catarino,John S. Duncan,Dalia Kasperaviciūte,Sarah K. Tate,Luis O. Caboclo,Josemir W. Sander,Lisa M. S. Clayton,Kristen N. Linney,Kevin V. Shianna,Curtis Gumbs,Jason Smith,Kenneth D. Cronin,Jessica M. Maia,Colin P. Doherty,Massimo Pandolfo,David Leppert,David Leppert,Lefkos T. Middleton,Rachel A. Gibson,Marvin Johnson,Marvin Johnson,Paul M. Matthews,Paul M. Matthews,David A. Hosford,Reetta Kälviäinen,Kai Eriksson,Anne-Mari Kantanen,Thomas Dorn,Jörg Hansen,Günter Krämer,Bernhard J. Steinhoff,Heinz Gregor Wieser,Dominik Zumsteg,Marcos Ortega,Nicholas W. Wood,Julie Huxley-Jones,Mohamad A. Mikati,William Gallentine,Aatif M. Husain,Patrick G. Buckley,Raymond L. Stallings,Mihai V. Podgoreanu,Norman Delanty,Sanjay M. Sisodiya,David Goldstein +53 more
TL;DR: Genome-wide screens to identify copy number variation in patients with a diverse spectrum of epilepsy syndromes and in neurologically-normal controls implicate 16p13.11 and possibly other large deletions as risk factors for a wide range of epilepsy disorders, and they appear to point toward haploinsufficiency as a contributor to the pathogenicity of deletions.
Journal ArticleDOI
Long-term seizure outcomes following amygdalohippocampectomy
TL;DR: A reassessment of the long-term seizure outcomes in patients who underwent selective amygdalohippocampectomy (SelAH) for pharmacotherapy-resistant mesial temporal lobe epilepsy (MTLE) at the Zurich University Hospital from 1975 to 1999 concludes that SelAH is a safe and effective surgical procedure for MTLE.
Journal ArticleDOI
Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study
Dalia Kasperavičiūtė,Claudia B. Catarino,Erin L. Heinzen,Chantal Depondt,Gianpiero L. Cavalleri,Luis O. Caboclo,Sarah K. Tate,Jenny Jamnadas-Khoda,Krishna Chinthapalli,Lisa M. S. Clayton,Kevin V. Shianna,Rodney A. Radtke,Mohamad A. Mikati,William Gallentine,Aatif M. Husain,Saud Alhusaini,David Leppert,David Leppert,Lefkos T. Middleton,Lefkos T. Middleton,Rachel A. Gibson,Marvin Johnson,Paul M. Matthews,Paul M. Matthews,David A. Hosford,Kjell Heuser,Leslie Amos,Marcos Ortega,Dominik Zumsteg,Heinz Gregor Wieser,Bernhard J. Steinhoff,Günter Krämer,Jörg Hansen,Thomas Dorn,Anne-Mari Kantanen,Leif Gjerstad,Leif Gjerstad,Terhi Peuralinna,Dena G. Hernandez,Kai Eriksson,Reetta Kälviäinen,Colin P. Doherty,Nicholas W. Wood,Massimo Pandolfo,John S. Duncan,Josemir W. Sander,Norman Delanty,David Goldstein,Sanjay M. Sisodiya +48 more
TL;DR: It is shown that, at best, common genetic variation can only have a modest role in predisposition to the partial epilepsies when considered across syndromes in Europeans, and research efforts should also be directed towards identifying the multiple rare variants likely to account for at least part of the heritability of the partial seizures.