G
Günter Krämer
Researcher at University of Bonn
Publications - 90
Citations - 2591
Günter Krämer is an academic researcher from University of Bonn. The author has contributed to research in topics: Epilepsy & Medicine. The author has an hindex of 24, co-authored 78 publications receiving 2316 citations.
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Journal ArticleDOI
Targeted next generation sequencing as a diagnostic tool in epileptic disorders
Johannes R. Lemke,Erik Riesch,Tim Scheurenbrand,Max Schubach,Christian Wilhelm,Isabelle Steiner,Jörg Hansen,Carolina Courage,Sabina Gallati,Sarah Burki,Susi Strozzi,Barbara Goeggel Simonetti,Sebastian Grunt,Maja Steinlin,Michael Alber,Markus Wolff,Thomas Klopstock,Eva Christina Prott,Rüdiger Lorenz,Christiane Spaich,Sabine Rona,Maya Lakshminarasimhan,Judith Kröll,Thomas Dorn,Günter Krämer,Matthis Synofzik,Felicitas Becker,Yvonne G. Weber,Holger Lerche,Detlef Böhm,Saskia Biskup +30 more
TL;DR: Epilepsies have a highly heterogeneous background with a strong genetic contribution and the variety of unspecific and overlapping syndromic and nonsyndromic phenotypes often hampers a clear clinical diagnosis and prevents straightforward genetic testing.
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Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes.
Erin L. Heinzen,Rodney A. Radtke,Thomas J. Urban,Gianpiero L. Cavalleri,Chantal Depondt,Anna C. Need,Nicole M. Walley,Paola Nicoletti,Dongliang Ge,Claudia B. Catarino,John S. Duncan,Dalia Kasperaviciūte,Sarah K. Tate,Luis O. Caboclo,Josemir W. Sander,Lisa M. S. Clayton,Kristen N. Linney,Kevin V. Shianna,Curtis Gumbs,Jason Smith,Kenneth D. Cronin,Jessica M. Maia,Colin P. Doherty,Massimo Pandolfo,David Leppert,David Leppert,Lefkos T. Middleton,Rachel A. Gibson,Marvin Johnson,Marvin Johnson,Paul M. Matthews,Paul M. Matthews,David A. Hosford,Reetta Kälviäinen,Kai Eriksson,Anne-Mari Kantanen,Thomas Dorn,Jörg Hansen,Günter Krämer,Bernhard J. Steinhoff,Heinz Gregor Wieser,Dominik Zumsteg,Marcos Ortega,Nicholas W. Wood,Julie Huxley-Jones,Mohamad A. Mikati,William Gallentine,Aatif M. Husain,Patrick G. Buckley,Raymond L. Stallings,Mihai V. Podgoreanu,Norman Delanty,Sanjay M. Sisodiya,David Goldstein +53 more
TL;DR: Genome-wide screens to identify copy number variation in patients with a diverse spectrum of epilepsy syndromes and in neurologically-normal controls implicate 16p13.11 and possibly other large deletions as risk factors for a wide range of epilepsy disorders, and they appear to point toward haploinsufficiency as a contributor to the pathogenicity of deletions.
Journal ArticleDOI
De novo loss-or gain-of-function mutations in KCNA2 cause epileptic encephalopathy
Steffen Syrbe,Ulrike B. S. Hedrich,Erik Riesch,Tania Djémié,Stephan Müller,Rikke S. Møller,Bridget H. Maher,Bridget H. Maher,Laura Hernandez-Hernandez,Laura Hernandez-Hernandez,Matthis Synofzik,Hande Caglayan,Mutluay Arslan,José M. Serratosa,Michael Nothnagel,Patrick May,Roland Krause,Heidrun Löffler,Katja Detert,Thomas Dorn,Heinrich Vogt,Günter Krämer,Ludger Schöls,Primus E. Mullis,Tarja Linnankivi,Anna-Elina Lehesjoki,Katalin Sterbova,Dana Craiu,Dorota Hoffman-Zacharska,Christian Korff,Yvonne G. Weber,Maja Steinlin,Sabina Gallati,Astrid Bertsche,Matthias K. Bernhard,Andreas Merkenschlager,Wieland Kiess,Michael A. Gonzalez,Stephan Züchner,Aarno Palotie,Aarno Palotie,Aarno Palotie,Arvid Suls,Peter De Jonghe,Ingo Helbig,Ingo Helbig,Saskia Biskup,Markus Wolff,Snezana Maljevic,Rebecca Schüle,Rebecca Schüle,Sanjay M. Sisodiya,Sanjay M. Sisodiya,Sarah Weckhuysen,Holger Lerche,Johannes R. Lemke,Johannes R. Lemke +56 more
TL;DR: Next-generation sequencing results establish KCNA2 as a new gene involved in human neurodevelopmental disorders through two different mechanisms, predicting either hyperexcitability or electrical silencing of KV1.2-expressing neurons.
Journal ArticleDOI
A double-blind controlled clinical trial: oxcarbazepine versus sodium valproate in adults with newly diagnosed epilepsy
Walter Christe,Günter Krämer,Ulf Vigonius,Harald Pohlmann,Bernhard J. Steinhoff,Martin J. Brodie,Alan Moore +6 more
TL;DR: Support is provided for the efficacy and safety of OXC as first-line treatment in adults with PS and GTCS in a double-blind, randomized, parallel-group comparison with sodium valproate.
Journal ArticleDOI
Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A
Dalia Kasperavičiūtė,Claudia B. Catarino,Claudia B. Catarino,Mar Matarin,Costin Leu,Jan Novy,Jan Novy,Anna Tostevin,Anna Tostevin,Bárbara Leal,Ellen V. S. Hessel,Kerstin Hallmann,Michael S. Hildebrand,Hans-Henrik M. Dahl,Mina Ryten,Daniah Trabzuni,Adaikalavan Ramasamy,Adaikalavan Ramasamy,Saud Alhusaini,Saud Alhusaini,Colin P. Doherty,Thomas Dorn,Jörg Hansen,Günter Krämer,Bernhard J. Steinhoff,Dominik Zumsteg,Susan Duncan,Reetta Kälviäinen,Kai Eriksson,Anne-Mari Kantanen,Massimo Pandolfo,Ursula Gruber-Sedlmayr,Kurt Schlachter,Eva M. Reinthaler,Elisabeth Stögmann,Fritz Zimprich,Emilie Théâtre,Colin Smith,Terence J. O'Brien,Terence J. O'Brien,K. Meng Tan,K. Meng Tan,Slavé Petrovski,Slavé Petrovski,Angela Robbiano,Roberta Paravidino,Federico Zara,Pasquale Striano,Michael R. Sperling,Russell J. Buono,Hakon Hakonarson,João Chaves,Paulo Costa,Paulo Costa,Berta Martins da Silva,António Martins da Silva,Pierre N. E. De Graan,Bobby P. C. Koeleman,Albert J. Becker,Susanne Schoch,Marec von Lehe,Philipp S. Reif,Felix Rosenow,Felicitas Becker,Yvonne G. Weber,Holger Lerche,Karl Rössler,Michael Buchfelder,Hajo M. Hamer,Katja Kobow,Roland Coras,Ingmar Blümcke,Ingrid E. Scheffer,Ingrid E. Scheffer,Ingrid E. Scheffer,Samuel F. Berkovic,Michael E. Weale,Norman Delanty,Norman Delanty,Chantal Depondt,Gianpiero L. Cavalleri,Wolfram S. Kunz,Sanjay M. Sisodiya,Sanjay M. Sisodiya +83 more
TL;DR: Genetic analysis and meta-analysis suggest SCN1A involvement in a common epilepsy syndrome, give new direction to biological understanding of mesial temporal lobe epilepsy with hippocampal sclerosis with febrile seizures, and open avenues for investigation of prognostic factors and possible prevention of epilepsy in some children with febs.