Marcus D. Goncalves

TL;DR: In this article, the authors demonstrate that rapamycin disrupted a second mTOR complex, mTORC2, in vivo and that mTORc2 was required for the insulin-mediated suppression of hepatic gluconeogenesis.

TL;DR: It is shown, in several model tumours in mice, that systemic glucose–insulin feedback caused by targeted inhibition of this pathway is sufficient to activate PI3K signalling, even in the presence ofPI3K inhibitors.

TL;DR: This review will examine the changes that occur in the obese state and review the biologic mechanisms that connect these changes to increased cancer risk and targeted clinical trials examining the effects of behavioral modifications such as reduced carbohydrate intake, caloric restriction, structured exercise, and/or pharmacologic interventions in obese populations may help to reduce their cancer risk.

TL;DR: Oral administration of high-fructose corn syrup is investigated in adenomatous polyposis coli mutant mice, which are predisposed to develop intestinal tumors, to support the hypothesis that the combination of dietary glucose and fructose, even at a moderate dose, can enhance tumorigenesis.

TL;DR: The findings show that disruption of ActRIIB signaling is a viable pharmacological approach for treating obesity and diabetes.