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Xiang Li
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 12
Citations - 1287
Xiang Li is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Biology & Cancer. The author has an hindex of 6, co-authored 8 publications receiving 673 citations. Previous affiliations of Xiang Li include Cornell University.
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Journal ArticleDOI
Suppression of insulin feedback enhances the efficacy of PI3K inhibitors
Benjamin D. Hopkins,Chantal Pauli,Chantal Pauli,Xing Du,Diana G. Wang,Diana G. Wang,Xiang Li,David Wu,Solomon C. Amadiume,Marcus D. Goncalves,Cindy Hodakoski,Mark R. Lundquist,Rohan Bareja,Rohan Bareja,Yan Ma,Emily M. Harris,Andrea Sboner,Himisha Beltran,Himisha Beltran,Mark A. Rubin,Mark A. Rubin,Siddhartha Mukherjee,Lewis C. Cantley +22 more
TL;DR: It is shown, in several model tumours in mice, that systemic glucose–insulin feedback caused by targeted inhibition of this pathway is sufficient to activate PI3K signalling, even in the presence ofPI3K inhibitors.
Journal ArticleDOI
Senolytic CAR T cells reverse senescence-associated pathologies.
Corina Amor,Judith Feucht,Josef Leibold,Yu-Jui Ho,Changyu Zhu,Direna Alonso-Curbelo,Jorge Mansilla-Soto,Jacob A. Boyer,Xiang Li,Xiang Li,Theodoros Giavridis,Amanda Kulick,Shauna L. Houlihan,Ellinor I.B. Peerschke,Scott L. Friedman,Vladimir Ponomarev,Alessandra Piersigilli,Michel Sadelain,Scott W. Lowe,Scott W. Lowe +19 more
TL;DR: Chimeric antigen receptor (CAR) T cells targeting uPAR, a cell-surface protein that is upregulated on senescent cells, eliminate senescence cells in vitro and in vivo and reduce liver fibrosis in mice.
Journal ArticleDOI
p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression
Sung-Hwan Moon,Chun-Hao Huang,Chun-Hao Huang,Chun-Hao Huang,Shauna L. Houlihan,Kausik Regunath,William A. Freed-Pastor,John P. Morris,Darjus F. Tschaharganeh,Edward R. Kastenhuber,Anthony M. Barsotti,Rachel Culp-Hill,Wen Xue,Yu-Jui Ho,Timour Baslan,Xiang Li,Xiang Li,Allison Mayle,Elisa de Stanchina,Lars Zender,David R. Tong,Angelo D'Alessandro,Scott W. Lowe,Carol Prives +23 more
TL;DR: It is demonstrated that repression of the mevalonate pathway is a crucial component of p53-mediated liver tumor suppression and the mechanism by which this occurs is outlined.
Journal ArticleDOI
The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma
Ana Banito,Xiang Li,Aimée N. Laporte,Jae Seok Roe,Francisco Sanchez-Vega,Chun-Hao Huang,Amanda R. Dancsok,Katerina Hatzi,Chi-Chao Chen,Chi-Chao Chen,Darjus F. Tschaharganeh,Rohit Chandwani,Nilgun Tasdemir,Kevin B. Jones,Mario R. Capecchi,Christopher R. Vakoc,Nikolaus Schultz,Marc Ladanyi,Torsten O. Nielsen,Scott W. Lowe,Scott W. Lowe +20 more
TL;DR: SS18-SSX1 deregulates developmental programs to drive transformation by hijacking a transcriptional repressive complex to aberrantly activate gene expression in synovial sarcoma cells, leading to irreversible mesenchymal differentiation.
Journal ArticleDOI
Vitamin B6 Addiction in Acute Myeloid Leukemia
Chi-Chao Chen,Chi-Chao Chen,Bo Li,Scott E. Millman,Cynthia Chen,Xiang Li,Xiang Li,John P. Morris,Allison Mayle,Yu-Jui Ho,Evangelia Loizou,Evangelia Loizou,Hui Liu,Weige Qin,Hardik Shah,Sara Violante,Justin R. Cross,Scott W. Lowe,Scott W. Lowe,Lingbo Zhang +19 more
TL;DR: The vitamin B6 pathway is identified as a pharmacologically actionable dependency in AML and disruption of PLP-dependent enzymes ODC1 or GOT2 selectively inhibited AML cell proliferation and their downstream products partially rescued PDXK disruption induced proliferation blockage.