M
Maria M. M. Santos
Researcher at University of Lisbon
Publications - 87
Citations - 2146
Maria M. M. Santos is an academic researcher from University of Lisbon. The author has contributed to research in topics: Apoptosis & Cancer. The author has an hindex of 23, co-authored 81 publications receiving 1801 citations. Previous affiliations of Maria M. M. Santos include Universidade Federal Rural do Rio de Janeiro & University of Barcelona.
Papers
More filters
Journal ArticleDOI
Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study.
Ana S. Newton,Paulo M.C. Glória,Lídia Gonçalves,Daniel J. V. A. dos Santos,Rui Moreira,Rita C. Guedes,Maria M. M. Santos +6 more
TL;DR: The first structure-activity relationship study of vinyl sulfones as caspase-3 inhibitors is reported in this paper, where a series of 12 vinyl sulfone derivatives were synthesized and evaluated for two downstream caspases (caspases-3 and -7).
Journal ArticleDOI
Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule
Joana Soares,Liliana Raimundo,Nuno A. L. Pereira,Ângelo Monteiro,Sara Gomes,Cláudia Bessa,Clara Pereira,Glória Queiroz,Alessandra Bisio,João Fernandes,Célia Gomes,Flávio Reis,Jorge Gonçalves,Alberto Inga,Maria M. M. Santos,Lucília Saraiva +15 more
TL;DR: The identification of the enantiopure tryptophanol-derived oxazoloisoindolinone SLMP53-1 as a novel reactivator of wild-type and mut p53, using a yeast-based screening strategy, represents a promissing starting point for the development of effective p53-reactivating drugs.
Journal ArticleDOI
Biogenetically inspired enantioselective approach to Indolo[2,3-a]- and benzo[a]quinolizidine alkaloids from a synthetic equivalent of secologanin.
Oriol Bassas,Núria Llor,Maria M. M. Santos,Rosa Griera,Elies Molins,Mercedes Amat,Joan Bosch +6 more
TL;DR: Racemic oxodiester 1 undergoes stereoselective cyclocondensation with (S)-tryptophanol, (3,4-dimethoxyphenyl)alaninol, or the corresponding amino acids, to give bicyclic lactams, which are cyclized to substituted indolo[2,3-a]- and benzo[a]quinolizidines.
Journal ArticleDOI
Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials.
TL;DR: Coupling a 7-chloroquinoline moiety to the 3-methylene-substituted indolinone scaffold led to a significant improvement in antiplasmodial activity.
Journal ArticleDOI
Aspartic vinyl sulfones: Inhibitors of a caspase-3-dependent pathway
Paulo M.C. Glória,Isabel Coutinho,Lídia Gonçalves,Cristina Baptista,Joana Soares,Ana S. Newton,Rui Moreira,Lucília Saraiva,Maria M. M. Santos +8 more
TL;DR: It is suggested that vinyl sulfones containing Asp at P1 should be considered for further optimization as caspase inhibitors and modulators of casp enzyme-3-dependent pathways.