Journal ArticleDOI
Cancer metabolism: a therapeutic perspective
Ubaldo E. Martinez-Outschoorn,Maria Peiris-Pagès,Richard G. Pestell,Federica Sotgia,Federica Sotgia,Michael P. Lisanti +5 more
TLDR
How cancer cells reprogramme their metabolism and that of other cells within the tumour microenvironment in order to survive and propagate, thus driving disease progression is discussed; in particular, potential metabolic vulnerabilities that might be targeted therapeutically are highlighted.Abstract:
Awareness that the metabolic phenotype of cells within tumours is heterogeneous - and distinct from that of their normal counterparts - is growing. In general, tumour cells metabolize glucose, lactate, pyruvate, hydroxybutyrate, acetate, glutamine, and fatty acids at much higher rates than their nontumour equivalents; however, the metabolic ecology of tumours is complex because they contain multiple metabolic compartments, which are linked by the transfer of these catabolites. This metabolic variability and flexibility enables tumour cells to generate ATP as an energy source, while maintaining the reduction-oxidation (redox) balance and committing resources to biosynthesis - processes that are essential for cell survival, growth, and proliferation. Importantly, experimental evidence indicates that metabolic coupling between cell populations with different, complementary metabolic profiles can induce cancer progression. Thus, targeting the metabolic differences between tumour and normal cells holds promise as a novel anticancer strategy. In this Review, we discuss how cancer cells reprogramme their metabolism and that of other cells within the tumour microenvironment in order to survive and propagate, thus driving disease progression; in particular, we highlight potential metabolic vulnerabilities that might be targeted therapeutically.read more
Citations
More filters
Journal ArticleDOI
Recent Progress in Ferroptosis Inducers for Cancer Therapy
TL;DR: A literature review of ferroptosis inducers (including small molecules and nanomaterials) is presented to delineate their design, action mechanisms, and anticancer applications.
Journal ArticleDOI
Mitochondrial metabolism and cancer.
Paolo E. Porporato,Nicoletta Filigheddu,José Manuel Bravo-San Pedro,Guido Kroemer,Lorenzo Galluzzi,Lorenzo Galluzzi +5 more
TL;DR: The cancer cell-intrinsic and cell-extrinsics mechanisms through which mitochondria influence all steps of oncogenesis are reviewed, with a focus on the therapeutic potential of targeting mitochondrial metabolism for cancer therapy.
Journal ArticleDOI
Effects of Intermittent Fasting on Health, Aging, and Disease
Rafael de Cabo,Mark P. Mattson +1 more
TL;DR: Effects of Intermittent Fasting on Health and Aging evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base fasting.
Journal ArticleDOI
ESPEN expert group recommendations for action against cancer-related malnutrition.
Jann Arends,Vickie E. Baracos,Hartmut Bertz,Federico Bozzetti,Philip C. Calder,Nicolaas E. P. Deutz,N. Erickson,Alessandro Laviano,Michael P. Lisanti,Dileep N. Lobo,Donald C. McMillan,Maurizio Muscaritoli,Johann Ockenga,Matthias Pirlich,Florian Strasser,M.A.E. de van der Schueren,A. Van Gossum,Peter Vaupel,Arved Weimann +18 more
TL;DR: The causes and consequences of cancer-related malnutrition are examined, treatment approaches currently available are reviewed, and the rationale and impetus for clinicians involved with care of patients with cancer to take actions that facilitate nutrition support in practice are built.
Journal ArticleDOI
T Cell Dysfunction in Cancer.
TL;DR: The current understanding of T cell dysfunction in cancer, the value of novel technologies to dissect such dysfunction at the single cell level, and how the emerging understanding may be utilized to develop personalized strategies to restore antitumor immunity are discussed.
References
More filters
Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
Journal ArticleDOI
Microbial ecology: Human gut microbes associated with obesity
TL;DR: It is shown that the relative proportion of Bacteroidetes is decreased in obese people by comparison with lean people, and that this proportion increases with weight loss on two types of low-calorie diet.
Journal ArticleDOI
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
TL;DR: Hypoxia-inducible factor 1 (HIF-1) is found in mammalian cells cultured under reduced O2 tension and is necessary for transcriptional activation mediated by the erythropoietin gene enhancer in hypoxic cells.