M
Maria Ringvall
Researcher at Uppsala University
Publications - 22
Citations - 1964
Maria Ringvall is an academic researcher from Uppsala University. The author has contributed to research in topics: Heparan sulfate & Serglycin. The author has an hindex of 16, co-authored 22 publications receiving 1844 citations. Previous affiliations of Maria Ringvall include Swedish University of Agricultural Sciences.
Papers
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Journal ArticleDOI
Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme
Erik Forsberg,Gunnar Pejler,Maria Ringvall,Carolina Lunderius,Bianca R. Tomasini-Johansson,Marion Kusche-Gullberg,Inger Eriksson,Johan Ledin,Lars Hellman,Lena Kjellén +9 more
TL;DR: The results indicate that one site of physiological action for heparin could be inside connective-tissue-type mast cells, where its absence results in severe defects in the secretory granules.
Book ChapterDOI
Mast cell proteases.
TL;DR: This chapter summarizes the current knowledge of the biology of the MC proteases, which will enable us to unravel the role of theMC proteases both in normal physiology as well as in pathological settings.
Journal ArticleDOI
Defective heparan sulfate biosynthesis and neonatal lethality in mice lacking N-deacetylase/N-sulfotransferase-1
Maria Ringvall,Johan Ledin,Katarina Holmborn,Toin H. van Kuppevelt,Fredrik Ellin,Inger Eriksson,Anne-Mari Olofsson,Lena Kjellén,Erik Forsberg +8 more
TL;DR: It is reported that targeted gene disruption of NDST-1 in the mouse results in a structural alteration of heparan sulfate in most basement membranes as revealed by immunohistochemical staining of fetal tissue sections using antibodies raised against heparin sulfate.
Journal ArticleDOI
Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development
Alexandra Abramsson,Sindhulakshmi Kurup,Marta Busse,Shuhei Yamada,Per Lindblom,Edith Schallmeiner,Denise Stenzel,Dominique Sauvaget,Johan Ledin,Maria Ringvall,Ulf Landegren,Lena Kjellén,Göran Bondjers,Jin-Ping Li,Ulf Lindahl,Dorothe Spillmann,Christer Betsholtz,Holger Gerhardt +17 more
TL;DR: It is concluded that pericyte recruitment requires HS with sufficiently extended and appropriately spaced N-sulfated domains to retain PDGF-BB and activate PDGF receptor beta (PDGFRbeta) signaling, whereas the detailed sequence of monosaccharide and sulfate residues does not appear to be important for this interaction.
Journal ArticleDOI
Heparan sulfate and development: differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes.
Kay Grobe,Johan Ledin,Maria Ringvall,Katarina Holmborn,Erik Forsberg,Jeffrey D. Esko,Lena Kjellén +6 more
TL;DR: The role of the four vertebrate NDSTs in HS biosynthesis as well as their regulated expression are reviewed, with the main emphasis is the phenotypes of mice lacking one or more of theNDSTs.