Maria Szomek

TL;DR: A model for sterol integration is proposed that clarifies the role of NPC proteins in this essential eukaryotic pathway and that rationalizes mutations in patients with Niemann-Pick disease type C.

TL;DR: It is deduced that sterols comprise up to ~45% of all inner leaflet lipids in the PM, a result that necessitates revision of current models of the architecture of the PM lipid bilayer.

TL;DR: This study shows that cholesterol esterification and trafficking of sterols between the PM and LE/LYSs depends on a functional NPC2 protein, which likely acts inside LE/LySs from where it increases non-vesicular sterol exchange with other organelles.

TL;DR: In this paper, the Niemann-Pick C2 protein (NPC2) was found to facilitate non-vesicular sterol exchange with the plasma membrane for subsequent sterol efflux to acceptor proteins and shedding of sterol-rich vesicles from the cell surface.

TL;DR: In this article, the authors present synthesis approaches to a series of monosubstituted Nile Red derivatives (9-diethylbenzo[a]phenoxazin-5-ones) starting from 1-naphthols or 1,3naphthalenediols.