K
Kerstin C. Maier
Researcher at Max Planck Society
Publications - 26
Citations - 1677
Kerstin C. Maier is an academic researcher from Max Planck Society. The author has contributed to research in topics: RNA polymerase II & RNA. The author has an hindex of 15, co-authored 25 publications receiving 1417 citations. Previous affiliations of Kerstin C. Maier include Center for Integrated Protein Science Munich & Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Dynamic transcriptome analysis measures rates of mRNA synthesis and decay in yeast
Christian Miller,Björn Schwalb,Kerstin C. Maier,Daniel Schulz,Sebastian Dümcke,Benedikt Zacher,Andreas Mayer,Jasmin F. Sydow,Lisa Marcinowski,Lars Dölken,Dietmar E. Martin,Achim Tresch,Patrick Cramer +12 more
TL;DR: DTA realistically monitors the dynamics in mRNA metabolism that underlie gene regulatory systems, and can monitor the cellular response to osmotic stress with higher sensitivity and temporal resolution than standard transcriptomics.
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Global analysis of eukaryotic mRNA degradation reveals Xrn1-dependent buffering of transcript levels.
Mai Sun,Björn Schwalb,Nicole Pirkl,Kerstin C. Maier,Arne Schenk,Henrik Failmezger,Achim Tresch,Patrick Cramer +7 more
TL;DR: It is shown that buffering of mRNA levels requires the RNA exonuclease Xrn1, and cluster analysis of the data defines the general mRNA degradation machinery, reveals different substrate preferences for the two mRNA deadenylase complexes Ccr4-Not and Pan2-Pan3, and unveils an interwoven cellular mRNA surveillance network.
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rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.
Jürgen Glas,Julia Seiderer,Martin Wetzke,Astrid Konrad,Helga-Paula Török,Silke Schmechel,Laurian Tonenchi,Christine Grassl,Julia Dambacher,Simone Pfennig,Kerstin C. Maier,Thomas Griga,Wolfram Klein,Jörg T. Epplen,Uwe Schiemann,Christian Folwaczny,Peter Lohse,Burkhard Göke,Thomas Ochsenkühn,Bertram Müller-Myhsok,Matthias Folwaczny,Thomas Mussack,Stephan Brand +22 more
TL;DR: IL23R is an IBD susceptibility gene, but has no epistatic interaction with CARD15 and SLC22A4/5.
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Calcium-mediated actin reset (CaAR) mediates acute cell adaptations
Pauline Wales,Christian Schuberth,Roland Aufschnaiter,Johannes Fels,Ireth García-Aguilar,Annette Janning,Christopher P Dlugos,Marco Schäfer-Herte,C. Klingner,C. Klingner,Mike Wälte,Julian Kuhlmann,Ekaterina Menis,Laura Hockaday Kang,Kerstin C. Maier,Wenya Hou,Antonella Russo,Henry N. Higgs,Hermann Pavenstädt,Thomas Vogl,Johannes Roth,Britta Qualmann,Michael M. Kessels,Dietmar E. Martin,Bela M. Mulder,Roland Wedlich-Söldner +25 more
TL;DR: Calcium-mediated actin reset (CaAR) leads to transient immobilization of organelles, drives reorganization of actin during cell cortex repair, cell spreading and wound healing, and induces long-lasting changes in gene expression, suggesting that CaAR acts as fundamental facilitator of cellular adaptations in response to acute signals and stress.
Journal ArticleDOI
Determinants of RNA metabolism in the Schizosaccharomyces pombe genome
Philipp Eser,Philipp Eser,Leonhard Wachutka,Kerstin C. Maier,Carina Demel,Mariana Boroni,Srignanakshi Iyer,Patrick Cramer,Julien Gagneur +8 more
TL;DR: The approach reveals distinct kinetics of mRNA and ncRNA metabolism, separates antisense regulation by transcription interference from RNA interference, and provides a general tool for studying the regulatory code of genomes.