Cyanines during the 1990s: A Review

Anti-cancer drugs

On the medicinal chemistry of gold complexes as anticancer drugs

Flipping the light switch 'on'--the design of sensor molecules that show cation-induced fluorescence enhancement with heavy and transition metal ions.

The coordination chemistry of guanidines and guanidinates

Mechanism of Cr(IV) and Cr(V) complex formation during the photochemical Cr(VI)-oxalic acid interaction in nonaqueous medium

Pyrophthalone and its derivatives as ligands—I. Mode of coordination—formation of isomeric iminopyrophthalone complexes

Sterically stabilized DPPC:CHOL:DSPE-PEG-2000 liposomal formulations of the lipophilic complexes of salinomycin with Na(I), K(I), Mn(II), Co(II), and Ni(II) ions were prepared by film-hydration method at different drug-to-DPPC molar ratios. For the K(I) and Na(I) complexes, optimal loading was established at a drug-to-DPPC molar ratio of 0.5:1, whereas for the Me(II) complexes, it was encountered at 0.1:1. DLS revealed uniform LUV populations (130-160 nm) with monomodal size distribution, further corroborated by AFM. Free and entrapped salinomycinates exhibited cytotoxicity in three human tumor cell lines, whereby the liposomal agents were superior vs. free complexes. DNA-fragmentation and flow cytometric assays showed that the cytotoxicity of free and liposomal salinomycinates is mediated by the induction of apoptosis and G1 arrest. The ability of the carriers to retain the bio-activity of the entrapped cargo gives us reason to conclude that the presented DPPC:CHOL:DSPE-PEG-2000 liposomes are suitable platforms for the salinomycin complexes, needing further evaluation and optimization.

Sterically stabilized liposomes as a platform for salinomycin metal coordination compounds

This study was designed to evaluate the potential application of monensin as an oral drug for the treatment of cadmium-induced hepatic dysfunction. The study was performed using ICR mouse model. Twenty-seven adult ICR male mice were divided into three groups of nine animals each: control (received distilled water and food ad libitum for 28 days); Cd-intoxicated (treated orally with 20 mg/kg b.w. Cd(II) acetate from the 1st to the 14th day of the experimental protocol); and monensin treated group (intoxicated with Cd(II) acetate as described for the Cd-intoxicated group followed by an oral treatment with 16 mg/kg b.w. tetraethylammonium salt of monensic acid for two weeks). The obtained results demonstrated that the treatment of Cd-intoxicated animals with monensin restored the liver weight/body weight index to normal values, decreased the concentration of the toxic metal ion by 50% compared to the Cd-treated controls, and recovered the homeostasis of Cu and Zn. Monensin reduced the activity of aspartate aminotransferase, alanine aminotrasnferase and alkaline phosphatase in the plasma of Cd-treated animals to the normal control levels and ameliorated the Cd-induced inflammation in the liver. Taken together, these data demonstrated that monensin could be an effective chelating agent for the treatment of Cd-induced hepatotoxicity.

Monensin ameliorates cadmium-induced hepatic injury in mice, subjected to subacute cadmium intoxication

A stable monomeric Pt(III) complex is obtained resulting from PtCl 4 2- - bilirubin interaction in basic-aqueous medium. By means of EPR method it is proven that in the course of the interaction a redox process proceeds, giving rise to a stable Pt(III) complex species and a free radical. On the basis of all spectroscopic (EPR, 195 Pt-NMR, IR, UV-Vis) and magnetochemical data obtained a square-pyramidal (e.g. distorted octahedral) structure is suggested. Most likely a biliverdin molecule (oxidation product of bilirubin) is placed in the xy plane, coordinated via the four pyrrole nitrogens of the ligand and the 5th site being occupied by a water molecule.

Mariana Mitewa

Papers

Mechanism of Cr(IV) and Cr(V) complex formation during the photochemical Cr(VI)-oxalic acid interaction in nonaqueous medium

Pyrophthalone and its derivatives as ligands—I. Mode of coordination—formation of isomeric iminopyrophthalone complexes

Sterically stabilized liposomes as a platform for salinomycin metal coordination compounds

Monensin ameliorates cadmium-induced hepatic injury in mice, subjected to subacute cadmium intoxication

Formation and Stabilization of Monomeric Pt(Iii) Species Through Complexation With Linear Tetrapyrrole Ligand Bilirubin