M
Mariano J. Levin
Researcher at National Scientific and Technical Research Council
Publications - 126
Citations - 7221
Mariano J. Levin is an academic researcher from National Scientific and Technical Research Council. The author has contributed to research in topics: Trypanosoma cruzi & Chagas disease. The author has an hindex of 43, co-authored 126 publications receiving 6895 citations. Previous affiliations of Mariano J. Levin include Laboratory of Molecular Biology & Fundación Favaloro.
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Journal ArticleDOI
The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease
Najib M. El-Sayed,Peter J. Myler,Peter J. Myler,Daniella Castanheira Bartholomeu,Daniel Nilsson,Gautam Aggarwal,Anh-Nhi Tran,Elodie Ghedin,Elizabeth A. Worthey,Arthur L. Delcher,Gaëlle Blandin,Scott J. Westenberger,Elisabet Caler,Gustavo C. Cerqueira,Carole Branche,Brian J. Haas,Atashi Anupama,Erik Arner,Lena Åslund,Philip Attipoe,Esteban J. Bontempi,Frédéric Bringaud,Peter Burton,Eithon Cadag,David A. Campbell,Mark Carrington,Jonathan Crabtree,Hamid Darban,José Franco da Silveira,Pieter J. de Jong,Kimberly Edwards,Paul T. Englund,Gholam Fazelina,Tamara Feldblyum,Marcela Ferella,Alberto C.C. Frasch,Keith Gull,David Horn,Lihua Hou,Yiting Huang,Ellen Kindlund,Michele M. Klingbeil,Sindy Kluge,Hean Koo,Daniela R. Lacerda,Mariano J. Levin,Hernan Lorenzi,Tin Louie,Carlos Renato Machado,Richard McCulloch,Alan McKenna,Yumi Mizuno,Jeremy C. Mottram,Siri Nelson,Stephen Ochaya,Kazutoyo Osoegawa,Grace Pai,Marilyn Parsons,Marilyn Parsons,Martin Pentony,Ulf Pettersson,Mihai Pop,José Luis Ramírez,Joel Rinta,Laura Robertson,Steven L. Salzberg,Daniel O. Sánchez,Amber Seyler,Reuben Sunil Kumar Sharma,Jyoti Shetty,Anjana J. Simpson,Ellen Sisk,Martti T. Tammi,Martti T. Tammi,Rick L. Tarleton,Santuza M. R. Teixeira,Susan Van Aken,Christy Vogt,Pauline N. Ward,Bill Wickstead,Jennifer R. Wortman,Owen White,Claire M. Fraser,Kenneth Stuart,Kenneth Stuart,Björn Andersson +85 more
TL;DR: Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.
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Accurate real-time PCR strategy for monitoring bloodstream parasitic loads in chagas disease patients.
Tomás Duffy,Margarita Bisio,Jaime Altcheh,Juan M. Burgos,Mirta Diez,Mariano J. Levin,Roberto R. Favaloro,Héctor Freilij,Alejandro G. Schijman +8 more
TL;DR: The high analytical sensitivity of the Q-PCR strategy, the low levels of intra- and inter-assay variations, as well as the accuracy provided by the Lg- PCR based correction factor support this methodology as a key laboratory tool for monitoring clinical reactivation and etiological treatment outcome in Chagas disease patients.
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Aetiological treatment of congenital Chagas’ disease diagnosed and monitored by the polymerase chain reaction
Alejandro G. Schijman,Jaime Altcheh,Juan M. Burgos,M. Biancardi,Margarita Bisio,Mariano J. Levin,Héctor Freilij +6 more
TL;DR: PCR was useful for sensitive diagnosis and therapy monitoring, allowing early detection of refractory cases and suggesting that in undetermined patients, undetectable parasitic burdens may lead to better post-treatment prognosis.
Journal ArticleDOI
Transferrin gene expression visualized in oligodendrocytes of the rat brain by using in situ hybridization and immunohistochemistry
TL;DR: Results provide evidence that the transferrin gene is expressed in the central nervous system and that transferrin is synthesized by and stored within oligodendrocytes in the adult rat brain, and suggest that this molecule could have a specific function in nervous system activity.
Journal ArticleDOI
Direct molecular profiling of minicircle signatures and lineages of Trypanosoma cruzi bloodstream populations causing congenital Chagas disease
Juan M. Burgos,Jaime Altcheh,Margarita Bisio,Tomás Duffy,Helder Magno Silva Valadares,María Elena Seidenstein,Romina Valeria Piccinali,Jorge M. Freitas,Mariano J. Levin,Liliana Macchi,Andrea M. Macedo,Héctor Freilij,Alejandro G. Schijman +12 more
TL;DR: In this article, T. cruzi lineages were identified in blood samples from congenitally infected children, transmitting and non-transmitting mothers and unrelated Chagas disease patients, using improved PCR strategies targeted to nuclear genomic markers.