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Najib M. El-Sayed
Researcher at University of Maryland, College Park
Publications - 106
Citations - 10275
Najib M. El-Sayed is an academic researcher from University of Maryland, College Park. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 45, co-authored 103 publications receiving 9546 citations. Previous affiliations of Najib M. El-Sayed include University of Iowa & George Washington University.
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Journal ArticleDOI
The Genome of the African Trypanosome Trypanosoma brucei
Matthew Berriman,Elodie Ghedin,Elodie Ghedin,Christiane Hertz-Fowler,Gaëlle Blandin,Hubert Renauld,Daniella Castanheira Bartholomeu,Nicola Lennard,Elisabet Caler,N. Hamlin,Brian J. Haas,Ulrike Böhme,Linda Hannick,Martin Aslett,Joshua Shallom,Lucio Marcello,Lihua Hou,Bill Wickstead,U. Cecilia M. Alsmark,Claire Arrowsmith,Rebecca Atkin,Andrew Barron,Frédéric Bringaud,Karen Brooks,Mark Carrington,Inna Cherevach,Tracey-Jane Chillingworth,Carol Churcher,Louise Clark,Craig Corton,Ann Cronin,Robert L. Davies,Jonathon Doggett,Appolinaire Djikeng,Tamara Feldblyum,Mark C. Field,Audrey Fraser,Ian Goodhead,Zahra Hance,David Harper,Barbara Harris,Heidi Hauser,Jessica B. Hostetler,Al Ivens,Kay Jagels,David W. Johnson,Justin Johnson,Kristine Jones,Arnaud Kerhornou,Hean Koo,Natasha Larke,Scott M. Landfear,Christopher Larkin,Vanessa Leech,Alexandra Line,Angela Lord,Annette MacLeod,P. Mooney,Sharon Moule,David M. A. Martin,Gareth W. Morgan,Karen Mungall,Halina Norbertczak,Doug Ormond,Grace Pai,Christopher S. Peacock,Jeremy Peterson,Michael A. Quail,Ester Rabbinowitsch,Marie-Adèle Rajandream,Chris P Reitter,Steven L. Salzberg,Mandy Sanders,Seth Schobel,Sarah Sharp,Mark Simmonds,Anjana J. Simpson,Luke J. Tallon,C. Michael R. Turner,Andrew Tait,Adrian Tivey,Susan Van Aken,Danielle Walker,David Wanless,Shiliang Wang,Brian White,Owen White,Sally Whitehead,John Woodward,Jennifer R. Wortman,Mark Raymond Adams,T. Martin Embley,Keith Gull,Elisabetta Ullu,J. David Barry,Alan H. Fairlamb,Fred R. Opperdoes,Barclay G. Barrell,John E. Donelson,Neil Hall,Neil Hall,Claire M. Fraser,Sara E. Melville,Najib M. El-Sayed,Najib M. El-Sayed +104 more
TL;DR: Comparisons of the cytoskeleton and endocytic trafficking systems of Trypanosoma brucei with those of humans and other eukaryotic organisms reveal major differences.
Journal ArticleDOI
The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease
Najib M. El-Sayed,Peter J. Myler,Peter J. Myler,Daniella Castanheira Bartholomeu,Daniel Nilsson,Gautam Aggarwal,Anh-Nhi Tran,Elodie Ghedin,Elizabeth A. Worthey,Arthur L. Delcher,Gaëlle Blandin,Scott J. Westenberger,Elisabet Caler,Gustavo C. Cerqueira,Carole Branche,Brian J. Haas,Atashi Anupama,Erik Arner,Lena Åslund,Philip Attipoe,Esteban J. Bontempi,Frédéric Bringaud,Peter Burton,Eithon Cadag,David A. Campbell,Mark Carrington,Jonathan Crabtree,Hamid Darban,José Franco da Silveira,Pieter J. de Jong,Kimberly Edwards,Paul T. Englund,Gholam Fazelina,Tamara Feldblyum,Marcela Ferella,Alberto C.C. Frasch,Keith Gull,David Horn,Lihua Hou,Yiting Huang,Ellen Kindlund,Michele M. Klingbeil,Sindy Kluge,Hean Koo,Daniela R. Lacerda,Mariano J. Levin,Hernan Lorenzi,Tin Louie,Carlos Renato Machado,Richard McCulloch,Alan McKenna,Yumi Mizuno,Jeremy C. Mottram,Siri Nelson,Stephen Ochaya,Kazutoyo Osoegawa,Grace Pai,Marilyn Parsons,Marilyn Parsons,Martin Pentony,Ulf Pettersson,Mihai Pop,José Luis Ramírez,Joel Rinta,Laura Robertson,Steven L. Salzberg,Daniel O. Sánchez,Amber Seyler,Reuben Sunil Kumar Sharma,Jyoti Shetty,Anjana J. Simpson,Ellen Sisk,Martti T. Tammi,Martti T. Tammi,Rick L. Tarleton,Santuza M. R. Teixeira,Susan Van Aken,Christy Vogt,Pauline N. Ward,Bill Wickstead,Jennifer R. Wortman,Owen White,Claire M. Fraser,Kenneth Stuart,Kenneth Stuart,Björn Andersson +85 more
TL;DR: Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.
Journal ArticleDOI
The genome of the blood fluke Schistosoma mansoni
Matthew Berriman,Brian J. Haas,Brian J. Haas,Philip T. LoVerde,R. Alan Wilson,Gary P. Dillon,Gustavo C. Cerqueira,Susan T. Mashiyama,Bissan Al-Lazikani,Luiza F. Andrade,Peter D. Ashton,Martin Aslett,Daniella Castanheira Bartholomeu,Daniella Castanheira Bartholomeu,Gaëlle Blandin,Conor R. Caffrey,Avril Coghlan,Richard M.R. Coulson,Tim A. Day,Arthur L. Delcher,Ricardo DeMarco,Ricardo DeMarco,Appoliniare Djikeng,Tina Eyre,John Gamble,Elodie Ghedin,Elodie Ghedin,Yong-Hong Gu,Christiane Hertz-Fowler,Hirohisha Hirai,Yuriko Hirai,Robin Houston,Alasdair Ivens,David A. Johnston,David A. Johnston,Daniela R. Lacerda,Daniela R. Lacerda,Camila D. S. Macedo,Paul McVeigh,Zemin Ning,Guilherme Oliveira,John P. Overington,Julian Parkhill,Mihaela Pertea,Raymond J. Pierce,Anna V. Protasio,Michael A. Quail,Marie-Adèle Rajandream,Jane Rogers,Mohammed Sajid,Steven L. Salzberg,Mario Stanke,Adrian Tivey,Owen White,Owen White,David L. Williams,David L. Williams,Jennifer R. Wortman,Jennifer R. Wortman,Wenjie Wu,Mostafa Zamanian,Adhemar Zerlotini,Claire M. Fraser-Liggett,Claire M. Fraser-Liggett,Barclay G. Barrell,Najib M. El-Sayed,Najib M. El-Sayed +66 more
TL;DR: Analysis of the 363 megabase nuclear genome of the blood fluke, the first sequenced flatworm, and a representative of the Lophotrochozoa offers insights into early events in the evolution of the animals, including the development of a body pattern with bilateral symmetry, and theDevelopment of tissues into organs.
Journal ArticleDOI
The genome of the protist parasite Entamoeba histolytica
Brendan J. Loftus,Iain J. Anderson,Robert L. Davies,U. Cecilia M. Alsmark,John Samuelson,Paolo Amedeo,Paola Roncaglia,Matthew Berriman,Robert P. Hirt,Barbara J. Mann,Tomo Nozaki,Bernard B. Suh,Mihai Pop,Michael Duchêne,John P. Ackers,Egbert Tannich,Matthias Leippe,Margit Hofer,Iris Bruchhaus,Ute Willhoeft,Alok Bhattacharya,Tracey Chillingworth,Carol Churcher,Zahra Hance,Barbara Harris,David Harris,Kay Jagels,Sharon Moule,Karen Mungall,Doug Ormond,Rob Squares,Sally Whitehead,Michael A. Quail,Ester Rabbinowitsch,Halina Norbertczak,Claire Price,Zheng Wang,Nancy Guillén,Carol A. Gilchrist,Suzanne Stroup,Sudha Bhattacharya,Anuradha Lohia,Peter G. Foster,Thomas Sicheritz-Pontén,Christian Weber,Upinder Singh,Chandrama Mukherjee,Najib M. El-Sayed,William A. Petri,C. Graham Clark,T. Martin Embley,Bart Barrell,Claire M. Fraser,Neil Hall,Neil Hall +54 more
TL;DR: The genome of E. histolytica is presented, which reveals a variety of metabolic adaptations shared with two other amitochondrial protist pathogens: Giardia lamblia and Trichomonas vaginalis, and provides new insights into the workings and genome evolution of a major human pathogen.
Journal ArticleDOI
Comparative genomics of trypanosomatid parasitic protozoa.
Najib M. El-Sayed,Peter J. Myler,Peter J. Myler,Gaëlle Blandin,Matthew Berriman,Jonathan Crabtree,Gautam Aggarwal,Elisabet Caler,Hubert Renauld,Elizabeth A. Worthey,Christiane Hertz-Fowler,Elodie Ghedin,Christopher S. Peacock,Daniella Castanheira Bartholomeu,Brian J. Haas,Anh Nhi Tran,Jennifer R. Wortman,U. Cecilia M. Alsmark,Samuel V. Angiuoli,Atashi Anupama,Jonathan H. Badger,Frédéric Bringaud,Eithon Cadag,Jane M. Carlton,Gustavo C. Cerqueira,Todd Creasy,Arthur L. Delcher,Appolinaire Djikeng,T. Martin Embley,Christopher R. Hauser,Alasdair Ivens,Sarah K. Kummerfeld,José B. Pereira-Leal,Daniel Nilsson,Jeremy Peterson,Steven L. Salzberg,Joshua Shallom,Joana C. Silva,Jaideep P. Sundaram,Scott J. Westenberger,Owen White,Sara E. Melville,John E. Donelson,Björn Andersson,Kenneth Stuart,Kenneth Stuart,Neil Hall +46 more
TL;DR: No evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont is revealed, and a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters is revealed.