M
Michele M. Klingbeil
Researcher at University of Massachusetts Amherst
Publications - 30
Citations - 2123
Michele M. Klingbeil is an academic researcher from University of Massachusetts Amherst. The author has contributed to research in topics: DNA replication & Kinetoplast. The author has an hindex of 15, co-authored 28 publications receiving 1979 citations. Previous affiliations of Michele M. Klingbeil include Johns Hopkins University & University of Toledo.
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Journal ArticleDOI
The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease
Najib M. El-Sayed,Peter J. Myler,Peter J. Myler,Daniella Castanheira Bartholomeu,Daniel Nilsson,Gautam Aggarwal,Anh-Nhi Tran,Elodie Ghedin,Elizabeth A. Worthey,Arthur L. Delcher,Gaëlle Blandin,Scott J. Westenberger,Elisabet Caler,Gustavo C. Cerqueira,Carole Branche,Brian J. Haas,Atashi Anupama,Erik Arner,Lena Åslund,Philip Attipoe,Esteban J. Bontempi,Frédéric Bringaud,Peter Burton,Eithon Cadag,David A. Campbell,Mark Carrington,Jonathan Crabtree,Hamid Darban,José Franco da Silveira,Pieter J. de Jong,Kimberly Edwards,Paul T. Englund,Gholam Fazelina,Tamara Feldblyum,Marcela Ferella,Alberto C.C. Frasch,Keith Gull,David Horn,Lihua Hou,Yiting Huang,Ellen Kindlund,Michele M. Klingbeil,Sindy Kluge,Hean Koo,Daniela R. Lacerda,Mariano J. Levin,Hernan Lorenzi,Tin Louie,Carlos Renato Machado,Richard McCulloch,Alan McKenna,Yumi Mizuno,Jeremy C. Mottram,Siri Nelson,Stephen Ochaya,Kazutoyo Osoegawa,Grace Pai,Marilyn Parsons,Marilyn Parsons,Martin Pentony,Ulf Pettersson,Mihai Pop,José Luis Ramírez,Joel Rinta,Laura Robertson,Steven L. Salzberg,Daniel O. Sánchez,Amber Seyler,Reuben Sunil Kumar Sharma,Jyoti Shetty,Anjana J. Simpson,Ellen Sisk,Martti T. Tammi,Martti T. Tammi,Rick L. Tarleton,Santuza M. R. Teixeira,Susan Van Aken,Christy Vogt,Pauline N. Ward,Bill Wickstead,Jennifer R. Wortman,Owen White,Claire M. Fraser,Kenneth Stuart,Kenneth Stuart,Björn Andersson +85 more
TL;DR: Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.
Journal ArticleDOI
Multiple mitochondrial DNA polymerases in Trypanosoma brucei.
TL;DR: Kinetoplast DNA (kDNA), the unusual mitochondrial DNA of Trypanosoma brucei, is a network containing thousands of catenated circles, and database searching for a kDNA replicative polymerase revealed no mitochondrial pol gamma homolog, but four proteins related to bacterial pol I were identified.
Journal ArticleDOI
Trypanosoma brucei Has Two Distinct Mitochondrial DNA Polymerase β Enzymes
TL;DR: Green fluorescent protein fusion proteins and immunofluorescence demonstrate that both are mitochondrial, but their locations with respect to the mitochondrial DNA (kinetoplast DNA network) in this organism are strikingly different.
Journal ArticleDOI
Replication of kinetoplast DNA: an update for the new millennium.
James Morris,Mark E. Drew,Michele M. Klingbeil,Shawn A. Motyka,Tina T. Saxowsky,Zefeng Wang,Paul T. Englund +6 more
TL;DR: This review will describe the replication of kinetoplast DNA, a subject that the lab has studied for many years and the properties of the characterised kinetOPlast DNA replication proteins and the current model for kinetic replication are described.
Journal ArticleDOI
Trypanosoma brucei Orc1 is essential for nuclear DNA replication and affects both VSG silencing and VSG switching
Imaan Benmerzouga,Jeniffer Concepción-Acevedo,Hee-Sook Kim,Anthula V. Vandoros,George A. M. Cross,Michele M. Klingbeil,Bibo Li +6 more
TL;DR: It is shown that TbOrc1 is essential for nuclear DNA replication in mammalian‐infectious bloodstream and tsetse procyclic forms (BF and PF) and is also required to control telomere‐linked VSG expression and VSG switching.