Tin Louie

TL;DR: The organization of protein-coding genes into long, strand-specific, polycistronic clusters and lack of general transcription factors in the L. major, Trypanosoma brucei, and Tritryp genomes suggest that the mechanisms regulating RNA polymerase II–directed transcription are distinct from those operating in other eukaryotes, although the trypanosomatids appear capable of chromatin remodeling.

TL;DR: Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.

TL;DR: In this article , a polygenic score of 78 European ancestry sleep duration SNPs is associated with sleep duration in an African (n = 7288; p = 0.003), an East Asian (n= 13.618; p= 0.6x10-4), and a South Asian population, but not in a Hispanic/Latino cohort.

TL;DR: The results suggest that the genetic basis of sleep duration is at least partially shared across diverse ancestry groups, and in a pan-ancestry meta-analysis of genome-wide association studies for habitual sleep duration, 5 novel and 68 known loci are associated with genome- wide significance.