M
Mario R. Fernandez
Researcher at Eppley Institute for Research in Cancer and Allied Diseases
Publications - 27
Citations - 688
Mario R. Fernandez is an academic researcher from Eppley Institute for Research in Cancer and Allied Diseases. The author has contributed to research in topics: Kinase & KSR1. The author has an hindex of 10, co-authored 26 publications receiving 605 citations. Previous affiliations of Mario R. Fernandez include University of Nebraska Medical Center & University of California, Irvine.
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Journal ArticleDOI
KSR2 Is an Essential Regulator of AMP Kinase, Energy Expenditure, and Insulin Sensitivity
Diane L. Costanzo-Garvey,Paul T. Pfluger,Michele K. Dougherty,Jeffery L. Stock,Matthew Boehm,Oleg V. Chaika,Mario R. Fernandez,Kurt W. Fisher,Robert L. Kortum,Eun Gyoung Hong,John Y. Jun,Hwi Jin Ko,Aimee Schreiner,Deanna J. Volle,Tina Treece,Amy L. Swift,Mike Winer,Denise Chen,Min Wu,Lisa R. Leon,Andrey S. Shaw,John D. McNeish,Jason K. Kim,Deborah K. Morrison,Matthias H. Tschöp,Robert E. Lewis +25 more
TL;DR: It is demonstrated that ksr2(-/-) mice are highly efficient in conserving energy, revealing a novel role for KSR2 in AMPK-mediated regulation of energy metabolism.
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Mdm2 Binds to Nbs1 at Sites of DNA Damage and Regulates Double Strand Break Repair
TL;DR: Nbs1 is a novel p53-independent MDM2 binding protein and links Mdm2 to the Mre11-NBS1-Rad50-regulated DNA repair response, a DNA double strand break repair complex.
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Cycloadditions of cyanoketenes to cinnamylidenamines and benzylidenamines. Synthetic scope, stereochemistry, and mechanism
Harold W. Moore,Greg Hughes,Kasturi Srinivasachar,Mario R. Fernandez,Nghi V. Nguyen,Doug Schoon,Anne Tranne +6 more
TL;DR: Cycloaddition de cyanocetenes (t-butylcyanocetene, chlorocyanoceten, and hexynylcyclic-cyclic) aux imines du titre is discussed in this article.
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Kinase Suppressor of Ras 2 (KSR2) Regulates Tumor Cell Transformation via AMPK
TL;DR: Data show that KSR2 is essential to tumor cell energy homeostasis and critical to the integration of mitogenic and metabolic signaling pathways.
Journal ArticleDOI
Metalloprotease OMA1 Fine-tunes Mitochondrial Bioenergetic Function and Respiratory Supercomplex Stability.
Iryna Bohovych,Mario R. Fernandez,Jennifer J. Rahn,Krista D. Stackley,Jennifer E. Bestman,Annadurai Anandhan,Rodrigo Franco,Steven M. Claypool,Robert E. Lewis,Sherine S.L. Chan,Oleh Khalimonchuk +10 more
TL;DR: In this paper, the IMQC protease Oma1 is shown to be essential for the stability of the respiratory supercomplexes and thus balanced and tunable bioenergetic function.